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Hantaviruses—Infections, Epidemiology and Hosts

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Zoonoses - Infections Affecting Humans and Animals

Abstract

Hantaviruses are pathogens of emerging importance in different areas of the world with local outbreaks as reported in 2012 in the Yosemite national park in the US or in several endemic areas in Germany. Quite recently hantaviruses have also been detected on the African continent. The knowledge on respective small mammal hosts and virus types/subtypes has rapidly increased in the last years now including also insectivores, bats and with these several associated new viruses. Usually animals are asymptomatic reservoir carriers, although a few studies show effects on rodent populations. In humans clinical symptoms of hantavirus infections are depending on the virus type causing syndromes of different severity. However, as infections are often clinically inapparent, recorded case numbers may be underestimated. The epidemiology of hantaviruses is complex as multiple biotic and abiotic factors are involved, e.g. rodent population density, corresponding virus prevalence, mast, habitats, biodiversity, rodent ecology, or climate and local weather parameters.

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References

  • Abu Sin MS, Hautmann W et al (2007) Risk factors for hantavirus infection in Germany, 2005. Emerg Infect Dis 13(9):1364–1366

    PubMed Central  PubMed  Google Scholar 

  • Ahlm C, Linderholm M, Juto P, Stegmayr B, Settergren B (1994) Prevalence of serum IgG antibodies to Puumala virus (haemorrhagic fever with renal syndrome) in northern Sweden. Epidemiol Infect 113(1):129–136

    CAS  PubMed Central  PubMed  Google Scholar 

  • Ahlm C, Linden C, Linderholm M, Alexeyev OA, Billheden J, Elgh F et al (1998a) Central nervous system and ophthalmic involvement in nephropathia epidemica (European type of haemorrhagic fever with renal syndrome). J Infect 36(2):149–155

    Google Scholar 

  • Ahlm C, Thelin A, Elgh F, Juto P, Stiernstrom EL, Holmberg S et al (1998b) Prevalence of antibodies specific to Puumala virus among farmers in Sweden. Scand J Work Environ Health 24(2):104–108

    Google Scholar 

  • Ahlm C, Wallin K, Lundkvist A, Elgh F, Juto P, Merza M et al (2000) Serologic evidence of Puumala virus infection in wild moose in northern Sweden. Am J Trop Med Hyg 62(1):106–111

    Google Scholar 

  • Alexeyev OA, Morozov VG (1995) Neurological manifestations of hemorrhagic fever with renal syndrome caused by Puumala virus: review of 811 cases. Clin Infect Dis 20(2):255–258

    CAS  PubMed  Google Scholar 

  • Antic D, Kang CY, Spik K, Schmaljohn C, Vapalahti O, Vaheri A (1992) Comparison of the deduced gene products of the L, M and S genome segments of hantaviruses. Virus Res 24(1):35–46

    CAS  PubMed  Google Scholar 

  • Arai S, Song JW, Sumibcay L, Bennett SN, Nerurkar VR, Parmenter C et al (2007) Hantavirus in northern short-tailed shrew, United States. Emerg Infect Dis 13(9):1420–1423

    CAS  PubMed Central  PubMed  Google Scholar 

  • Arai S, Bennett SN, Sumibcay L, Cook JA, Song JW, Hope A et al (2008a) Phylogenetically distinct hantaviruses in the masked shrew (Sorex cinereus) and dusky shrew (Sorex monticolus) in the United States. Am J Trop Med Hyg 78(2):348–351

    Google Scholar 

  • Arai S, Ohdachi SD, Asakawa M, Kang HJ, Mocz G, Arikawa J et al (2008b) Molecular phylogeny of a newfound hantavirus in the Japanese shrew mole (Urotrichus talpoides). Proc Natl Acad Sci U S A 105(42):16296–16301

    Google Scholar 

  • Arai S, Gu SH, Baek LJ, Tabara K, Bennett SN, Oh HS, et al (2012) Divergent ancestral lineages of newfound hantaviruses harbored by phylogenetically related crocidurine shrew species in Korea. Virology 424(2):99–105

    CAS  PubMed Central  PubMed  Google Scholar 

  • Augot D, Sauvage F, Boue F, Bouloy M, Artois M, Demerson JM et al (2008) Spatial and temporal patterning of bank vole demography and the epidemiology of the Puumala hantavirus in northeastern France. Epidemiol Infect 136(12):1638–1643

    CAS  PubMed Central  PubMed  Google Scholar 

  • Avsic-Zupanc T, Xiao SY, Stojanovic R, Gligic A, van der Groen G, LeDuc JW (1992) Characterization of Dobrava virus: a Hantavirus from Slovenia, Yugoslavia. J Med Virol 38(2):132–137

    CAS  PubMed  Google Scholar 

  • Avsic-Zupanc T, Petrovec M, Furlan P, Kaps R, Elgh F, Lundkvist A (1999) Hemorrhagic fever with renal syndrome in the Dolenjska region of Slovenia-a 10-year survey. Clin Infect Dis 28(4):860–865

    CAS  PubMed  Google Scholar 

  • Avsic-Zupanc T, Petrovec M, Duh D, Plyusnina A, Lundkvist A, Plyusnin A (2007) Puumala hantavirus in Slovenia: analyses of S and M segment sequences recovered from patients and rodents. Virus Res 123(2):204–210

    CAS  PubMed  Google Scholar 

  • Bahr U, Muranyi W, Muller S, Kehm R, Handermann M, Darai G et al (2004) Bovine aortic endothelial cells are susceptible to Hantaan virus infection. Virology 321(1):1–7

    CAS  PubMed  Google Scholar 

  • Bayard V, Kitsutani PT, Barria EO, Ruedas LA, Tinnin DS, Munoz C et al (2004) Outbreak of hantavirus pulmonary syndrome, Los Santos, Panama, 1999–2000. Emerg Infect Dis 10(9):1635–1642

    PubMed Central  PubMed  Google Scholar 

  • Bennett M, Lloyd G, Jones N, Brown A, Trees AJ, McCracken C et al (1990) Prevalence of antibody to hantavirus in some cat populations in Britain. Vet Rec 127(22):548–549

    CAS  PubMed  Google Scholar 

  • Bi Z, Formenty PB, Roth CE (2008) Hantavirus infection: a review and global update. J Infect Dev Ctries 2(1):3–23

    PubMed  Google Scholar 

  • Boone I, Wagner-Wiening C, Reil D, Jacob J, Rosenfeld U, Ulrich R et al. (2012) Rise in the number of notified human hantavirus infections since October 2011 in Baden-Wurttemberg, Germany. Euro Surveill 17(21)

    Google Scholar 

  • Brummer-Korvenkontio M, Vapalahti O, Henttonen H, Koskela P, Kuusisto P, Vaheri A (1999) Epidemiological study of nephropathia epidemica in Finland 1989–1996. Scand J Infect Dis 31(5):427–435

    CAS  PubMed  Google Scholar 

  • Buranda T, Wu Y, Perez D, Jett SD, BonduHawkins V, Ye C et al (2010) Recognition of decay accelerating factor and alpha(v)beta(3) by inactivated hantaviruses: toward the development of high-throughput screening flow cytometry assays. Anal Biochem 402(2):151–160

    CAS  PubMed Central  PubMed  Google Scholar 

  • Buys KK, Jung KH, Smee DF, Furuta Y, Gowen BB (2011) Maporal virus as a surrogate for pathogenic New World hantaviruses and its inhibition by favipiravir. Antivir Chem Chemother 21(5):193–200

    CAS  PubMed Central  PubMed  Google Scholar 

  • Carey DE, Reuben R, Panicker KN, Shope RE, Myers RM (1971) Thottapalayam virus: a presumptive arbovirus isolated from a shrew in India. Indian J Med Res 59(11):1758–1760

    CAS  PubMed  Google Scholar 

  • Castillo C, Naranjo J, Sepulveda A, Ossa G, Levy H (2001) Hantavirus pulmonary syndrome due to Andes virus in Temuco, Chile: clinical experience with 16 adults. Chest 120(2):548–554

    CAS  PubMed  Google Scholar 

  • Chapman LE, Mertz GJ, Peters CJ, Jolson HM, Khan AS, Ksiazek TG et al (1999) Intravenous ribavirin for hantavirus pulmonary syndrome: safety and tolerance during 1 year of open-label experience. Ribavirin study group. Antivir Ther 4(4):211–219

    CAS  PubMed  Google Scholar 

  • Chen CC, Pei KJ, Yang CM, Kuo MD, Wong ST, Kuo SC et al (2011) A possible case of hantavirus infection in a Borneo orangutan and its conservation implication. J Med Primatol 40(1):2–5

    PubMed  Google Scholar 

  • Childs JE, Ksiazek TG, Spiropoulou CF, Krebs JW, Morzunov S, Maupin GO et al (1994) Serologic and genetic identification of Peromyscus maniculatus as the primary rodent reservoir for a new hantavirus in the southwestern United States. J Infect Dis 169(6):1271–1280

    CAS  PubMed  Google Scholar 

  • Clement J, McKenna P, Leirs H, Verhagen R, Lefevre A, Song G (eds) (1994) Hantavirus infections in rodents. In: Horzinek (eds) Virus infections of rodents and lagomorphs, 5th Volume in a Series. Elsevier Science, Amsterdam

    Google Scholar 

  • Clement J, Underwood P, Ward D, Pilaski J, LeDuc J (1996) Hantavirus outbreak during military manoeuvres in Germany. Lancet 347(8997):336

    CAS  PubMed  Google Scholar 

  • Connolly-Andersen AM, Ahlm K, Ahlm C, Klingstrom J (2013) Puumala virus infections associated with cardiovascular causes of death. Emerg Infect Dis 19(1):126–128

    PubMed Central  PubMed  Google Scholar 

  • Crowcroft NS, Infuso A, Ilef D, Le Guenno B, Desenclos JC, Van Loock F et al (1999) Risk factors for human hantavirus infection: Franco-Belgian collaborative case-control study during 1995–1996 epidemic. BMJ 318(7200):1737–1738

    CAS  PubMed Central  PubMed  Google Scholar 

  • Cvetko L, Markotic A, Plyusnina A, Margaletic J, Miletic-Medved M, Turk N et al (2005) Puumala virus in Croatia in the 2002 HFRS outbreak. J Med Virol 77(2):290–294

    PubMed  Google Scholar 

  • Danes L, Pejcoch M, Bukovjan K, Veleba J, Halackova M (1992) Antibodies against Hantaviruses in game and domestic oxen in the Czech Republic. Cesk Epidemiol Mikrobiol Imunol 41(1):15–18

    CAS  PubMed  Google Scholar 

  • Dara SI, Albright RC, Peters SG (2005) Acute sin nombre hantavirus infection complicated by renal failure requiring hemodialysis. Mayo Clin Proc 80(5):703–704

    PubMed  Google Scholar 

  • de Araujo JT, Dutra LM et al (2012) Detection of hantavirus in bats from remaining rain forest in Sao Paulo, Brazil. BMC Res Notes 5:690

    PubMed Central  PubMed  Google Scholar 

  • Dobly A, Cochez C, Goossens E, De Bosschere H, Hansen P, Roels S et al (2012) Sero-epidemiological study of the presence of hantaviruses in domestic dogs and cats from Belgium. Res Vet Sci 92(2):221–224

    CAS  PubMed  Google Scholar 

  • Drexler JF, Corman VM, Muller MA, Maganga GD, Vallo P, Binger T et al (2012) Bats host major mammalian paramyxoviruses. Nat Commun 3:796

    PubMed Central  PubMed  Google Scholar 

  • Duchin JS, Koster FT, Peters CJ, Simpson GL, Tempest B, Zaki SR et al (1994) Hantavirus pulmonary syndrome: a clinical description of 17 patients with a newly recognized disease. The hantavirus study group. N Engl J Med 330(14):949–955

    CAS  PubMed  Google Scholar 

  • Escadafal C, Avsic-Zupanc T, Vapalahti O, Niklasson B, Teichmann A, Niedrig M et al (2012) Second external quality assurance study for the serological diagnosis of hantaviruses. Europe PLoS Negl Trop Dis 6(4):e1607

    Google Scholar 

  • Escutenaire S, Pastoret PP, Sjolander KB, Heyman P, Brochier B, Lundkvist A (2000) Evidence of Puumala hantavirus infection in red foxes (Vulpes vulpes) in Belgium. Vet Rec 147(13):365–366

    CAS  PubMed  Google Scholar 

  • Essbauer S, Schmidt J, Conraths FJ, Friedrich R, Koch J, Hautmann W et al (2006) A new Puumala hantavirus subtype in rodents associated with an outbreak of Nephropathia epidemica in South-East Germany in 2004. Epidemiol Infect 134(6):1333–1344

    CAS  PubMed Central  PubMed  Google Scholar 

  • Essbauer SS, Schmidt-Chanasit J, Madeja EL, Wegener W, Friedrich R, Petraityte R et al (2007) Nephropathia epidemica in metropolitan area, Germany. Emerg Infect Dis 13(8):1271–1273

    PubMed Central  PubMed  Google Scholar 

  • Essbauer S, Cochez C, Marie J, Thoma B, Heyman P (2013) Epidemiology and driving factors of hantavirus infections in Western Europe. IRAFMS 85(4):25–45

    Google Scholar 

  • Ettinger J, Hofmann J, Enders M, Tewald F, Oehme RM, Rosenfeld UM et al (2012) Multiple synchronous Puumala hantaviurs outbreaks, 2010. Emerg Infect Dis 18(9):1461–1664

    PubMed Central  PubMed  Google Scholar 

  • Evander M, Ahlm C (2009) Milder winters in northern Scandinavia may contribute to larger outbreaks of haemorrhagic fever virus. Glob Health Action 2

    Google Scholar 

  • Faber MS, Ulrich RG, Frank C, Brockmann SO, Pfaff GM, Jacob J et al (2010) Steep rise in notified hantavirus infections in Germany, April 2010. Euro Surveill 15(20)

    Google Scholar 

  • Featherstone CA, Wyllie S, Frost AJ, McElhinney L (2013) Hantavirus and pet rodents. Vet Rec 172(14):370

    PubMed  Google Scholar 

  • Ferluga D, Vizjak A (2008) Hantavirus nephropathy. J Am Soc Nephrol 19(9):1653–1658

    CAS  PubMed  Google Scholar 

  • Ferres M, Vial P, Marco C, Yanez L, Godoy P, Castillo C et al (2007) Prospective evaluation of household contacts of persons with hantavirus cardiopulmonary syndrome in chile. J Infect Dis 195(11):1563–1571

    PubMed  Google Scholar 

  • Firth C, Tokarz R, Simith DB, Nunes MR, Bhat M, Rosa ES et al (2012) Diversity and distribution of hantaviruses in South America. J Virol 86(24):13756–13766

    CAS  PubMed Central  PubMed  Google Scholar 

  • Gajdusek DC (1956) Hemorrhagic fevers in Asia: a problem in medical ecology. Geog Rev 46:20–42

    Google Scholar 

  • Garanina SB, Platonov AE, Zhuravlev VI, Murashkina AN, Yakimenko VV, Korneev AG et al (2009) Genetic diversity and geographic distribution of hantaviruses in Russia. Zoonoses Public Health 56(6–7):297–309

    Google Scholar 

  • Gavrilovskaya IN, Shepley M, Shaw R, Ginsberg MH, Mackow ER (1998) beta3 Integrins mediate the cellular entry of hantaviruses that cause respiratory failure. Proc Natl Acad Sci U S A 95(12):7074–7079

    CAS  PubMed Central  PubMed  Google Scholar 

  • Gavrilovskaya IN, Brown EJ, Ginsberg MH, Mackow ER (1999) Cellular entry of hantaviruses which cause hemorrhagic fever with renal syndrome is mediated by beta3 integrins. J Virol 73(5):3951–3959

    CAS  PubMed Central  PubMed  Google Scholar 

  • Gonzalez JP, McCormick JB, Baudon D, Gautun JP, Meunier DY, Dournon E et al (1984) Serological evidence for Hantaan-related virus in Africa. Lancet 2(8410):1036–1037

    CAS  PubMed  Google Scholar 

  • Green W, Feddersen R, Yousef O, Behr M, Smith K, Nestler J et al (1998) Tissue distribution of hantavirus antigen in naturally infected humans and deer mice. J Infect Dis 177(6):1696–1700

    CAS  PubMed  Google Scholar 

  • Groen J, Gerding M, Koeman JP, Roholl PJ, van Amerongen G, Jordans HG et al (1995) A macaque model for hantavirus infection. J Infect Dis 172(1):38–44

    CAS  PubMed  Google Scholar 

  • Gu SH, Kang HJ, Baek LJ, Noh JY, Kim HC, Klein TA et al (2011) Genetic diversity of Imjin virus in the Ussuri white-toothed shrew (Crocidura lasiura) in the Republic of Korea, 2004–2010. Virol J 8:56

    PubMed Central  PubMed  Google Scholar 

  • Guo WP, Lin XD, Wang W, Zhang XH, Chen Y, Cao JH et al (2011) A new subtype of Thottapalayam virus carried by the Asian house shrew (Suncus murinus) in China. Infect Genet Evol 11(8):1862–1867

    CAS  PubMed  Google Scholar 

  • Guo WP, Lin XD, Wang W, Tian JH, Cong ML, Zhang HL et al (2013) Phylogeny and origins of hantaviruses harbored by bats, insectivores, and rodents. PLoS Pathog 9(2):e1003159

    CAS  PubMed Central  PubMed  Google Scholar 

  • Hall PR, Leitao A, Ye C, Kilpatrick K, Hjelle B, Oprea TI et al (2010) Small molecule inhibitors of hantavirus infection. Bioorg Med Chem Lett 20(23):7085–7091

    CAS  PubMed Central  PubMed  Google Scholar 

  • Hautala T, Sironen T, Vapalahti O, Paakko E, Sarkioja T, Salmela PI et al (2002) Hypophyseal hemorrhage and panhypopituitarism during Puumala Virus Infection: magnetic Resonance Imaging and detection of viral antigen in the hypophysis. Clin Infect Dis 35(1):96–101

    PubMed  Google Scholar 

  • Hautala T, Mahonen SM, Sironen T, Hautala N, Paakko E, Karttunen A et al (2010) Central nervous system-related symptoms and findings are common in acute Puumala hantavirus infection. Ann Med 42(5):344–351

    CAS  PubMed  Google Scholar 

  • Hautala T, Hautala N, Mahonen SM, Sironen T, Paakko E, Karttunen A et al (2011) Young male patients are at elevated risk of developing serious central nervous system complications during acute Puumala hantavirus infection. BMC Infect Dis 11:217

    PubMed Central  PubMed  Google Scholar 

  • Heider H, Ziaja B, Priemer C, Lundkvist A, Neyts J, Kruger DH et al (2001) A chemiluminescence detection method of hantaviral antigens in neutralisation assays and inhibitor studies. J Virol Methods 96(1):17–23

    CAS  PubMed  Google Scholar 

  • Henttonen H, Buchy P, Suputtamongkol Y, Jittapalapong S, Herbreteau V, Laakkonen J et al (2008) Recent discoveries of new hantaviruses widen their range and question their origins. Ann N Y Acad Sci 1149:84–89

    CAS  PubMed  Google Scholar 

  • Heyman P, Vaheri A (2008) Situation of hantavirus infections and haemorrhagic fever with renal syndrome in European countries as of December 2006. Euro Surveill 13(28)

    Google Scholar 

  • Heyman P, Plyusnina A, Berny P, Cochez C, Artois M, Zizi M et al (2004) Seoul hantavirus in Europe: first demonstration of the virus genome in wild Rattus norvegicus captured in France. Eur J Clin Microbiol Infect Dis 23(9):711–717

    CAS  PubMed  Google Scholar 

  • Heyman P, Cochez C, Ducoffre G, Mailles A, Zeller H, Abu Sin M et al (2007) Haemorrhagic Fever with Renal Syndrome: an analysis of the outbreaks in Belgium, France, Germany, The Netherlands and Luxembourg in 2005. Euro Surveill 12(5):E15–E16

    CAS  PubMed  Google Scholar 

  • Heyman P, Baert K, Plyusnina A, Cochez C, Lundkvist A, Esbroeck MV et al (2009a) Serological and genetic evidence for the presence of Seoul hantavirus in Rattus norvegicus in Flanders, Belgium. Scand J Infect Dis 41(1):51–56

    Google Scholar 

  • Heyman P, Vaheri A, Lundkvist A, Avsic-Zupanc T (2009b) Hantavirus infections in Europe: from virus carriers to a major public-health problem. Expert Rev Anti Infect Ther 7(2):205–217

    Google Scholar 

  • Heyman P, Ceianu CS, Christova I, Tordo N, Beersma M, Joao Alves M et al (2011) A five-year perspective on the situation of haemorrhagic fever with renal syndrome and status of the hantavirus reservoirs in Europe, 2005–2010. Euro Surveill 16(36)

    Google Scholar 

  • Heyman P, Thoma BR, Marie JL, Cochez C, Essbauer SS (2012) In search for factors that drive hantavirus epidemics. Front Physiol 3:237

    PubMed Central  PubMed  Google Scholar 

  • Heyman P, Cochez C, Simons L, Smets L, Saegerman C (2013) Breeding success of barn owls reflects risk of hantavirus infection. Vet Rec 172(11):290

    CAS  PubMed  Google Scholar 

  • Hjelle B, Torres-Perez F (2010) Hantaviruses in the Americas and their role as emerging pathogens. Viruses 2(12):2559–2586

    PubMed Central  PubMed  Google Scholar 

  • Hjelle B, Lee SW, Song W, Torrez-Martinez N, Song JW, Yanagihara R et al (1995) Molecular linkage of hantavirus pulmonary syndrome to the white-footed mouse, Peromyscus leucopus: genetic characterization of the M genome of New York virus. J Virol 69(12):8137–8141

    CAS  PubMed Central  PubMed  Google Scholar 

  • Hjelle B, Goade D, Torrez-Martinez N, Lang-Williams M, Kim J, Harris RL et al (1996) Hantavirus pulmonary syndrome, renal insufficiency, and myositis associated with infection by Bayou hantavirus. Clin Infect Dis 23(3):495–500

    CAS  PubMed  Google Scholar 

  • Hjertqvist M, Klein SL, Ahlm C, Klingstrom J (2010) Mortality rate patterns for hemorrhagic fever with renal syndrome caused by Puumala virus. Emerg Infect Dis 16(10):1584–1586

    PubMed Central  PubMed  Google Scholar 

  • Hofmann J, Meisel H, Klempa B, Vesenbeckh SM, Beck R, Michel D et al (2008) Hantavirus outbreak, Germany, 2007. Emerg Infect Dis 14(5):850–852

    PubMed Central  PubMed  Google Scholar 

  • Horling J, Cheng Y, Plyusnin A, Persson K, Lehvaslaiho H, Vaheri A et al (1995) Nucleotide and deduced amino acid sequences of the M and S genome segments of a Swedish Puumala virus isolate. Virus Res 39(2–3):321–330

    CAS  PubMed  Google Scholar 

  • Huang LY, Zhou H, Yin WW, Wang Q, Sun H, Ding F et al (2012) The current epidemic situation and surveillance regarding hemorrhagic fever with renal syndrome in China, 2010. Zhonghua Liu Xing Bing Xue Za Zhi 33(7):685–691

    PubMed  Google Scholar 

  • Huggins JW, Kim GR, Brand OM, McKee KT Jr (1986) Ribavirin therapy for Hantaan virus infection in suckling mice. J Infect Dis 153(3):489–497

    CAS  PubMed  Google Scholar 

  • Hughes AL, Friedman R (2000) Evolutionary diversification of protein-coding genes of hantaviruses. Mol Biol Evol 17(10):1558–1568

    CAS  PubMed  Google Scholar 

  • Huong VT, Yoshimatsu K, Luan VD, Tuan leV, Nhi L, Arikawa J et al (2010) Hemorrhagic fever with renal syndrome, Vietnam. Emerg Infect Dis 16(2):363–365

    PubMed Central  PubMed  Google Scholar 

  • Huttunen NP, Makela S, Pokka T, Mustonen J, Uhari M (2011) Systematic literature review of symptoms, signs and severity of serologically confirmed nephropathia epidemica in paediatric and adult patients. Scand J Infect Dis 43(6–7):405–410

    PubMed  Google Scholar 

  • Jameson L, Taori S, Atkinson B, Levick P, Featherstone C, van der Burgt G et al (2013a) Pet rats as a source of hantavirus in England and Wales, 2013. Euro Surveill 18(9)

    Google Scholar 

  • Jameson LJ, Logue CH, Atkinson B, Baker N, Galbraith SE, Carroll MW et al (2013b) The continued emergence of hantaviruses: isolation of a Seoul virus implicated in human disease, United Kingdom, October 2012. Euro Surveill 18(1):4–7

    Google Scholar 

  • Jonsson CB, Figueiredo LT, Vapalahti O (2010) A global perspective on hantavirus ecology, epidemiology, and disease. Clin Microbiol Rev 23(2):412–441

    CAS  PubMed Central  PubMed  Google Scholar 

  • Juncker-Voss M, Prosl H, Lussy H, Enzenberg U, Auer H, Lassnig H et al (2004) Screening for antibodies against zoonotic agents among employees of the Zoological Garden of Vienna, Schonbrunn, Austria. Berl Munch Tierarztl Wochenschr 117(9–10):404–409

    PubMed  Google Scholar 

  • Jung YT, Kim GR (1995) Genomic characterization of M and S RNA segments of hantaviruses isolated from bats. Acta Virol 39(4):231–233

    CAS  PubMed  Google Scholar 

  • Kanerva M, Vaheri A, Mustonen J, Partanen J (1998) High-producer allele of tumour necrosis factor-alpha is part of the susceptibility MHC haplotype in severe puumala virus-induced nephropathia epidemica. Scand J Infect Dis 30(5):532–534

    CAS  PubMed  Google Scholar 

  • Kang HJ, Arai S, Hope AG, Song JW, Cook JA, Yanagihara R (2009a) Genetic diversity and phylogeography of Seewis virus in the Eurasian common shrew in Finland and Hungary. Virol 6:208

    Google Scholar 

  • Kang HJ, Bennett SN, Dizney L, Sumibcay L, Arai S, Ruedas LA et al (2009b) Host switch during evolution of a genetically distinct hantavirus in the American shrew mole (Neurotrichus gibbsii). Virology 388(1):8–14

    Google Scholar 

  • Kang HJ, Bennett SN, Sumibcay L, Arai S, Hope AG, Mocz G et al (2009c) Evolutionary insights from a genetically divergent hantavirus harbored by the European common mole (Talpa europaea). PLoS ONE 4(7):e6149

    Google Scholar 

  • Kang HJ, Arai S, Hope AG, Cook JA, Yanagihara R (2010) Novel hantavirus in the flat-skulled shrew (Sorex roboratus). Vector Borne Zoonotic Dis 10(6):593–597

    PubMed Central  PubMed  Google Scholar 

  • Kang HJ, Bennett SN, Hope AG, Cook JA, Yanagihara R (2011a) Shared ancestry between a newfound mole-borne hantavirus and hantaviruses harbored by cricetid rodents. J Virol 85(15):7496–7503

    Google Scholar 

  • Kang HJ, Kadjo B, Dubey S, Jacquet F, Yanagihara R (2011b) Molecular evolution of Azagny virus, a newfound hantavirus harbored by the West African pygmy shrew (Crocidura obscurior) in Cote d’Ivoire. Virol J 8:373

    Google Scholar 

  • Kang HJ, Kosoy MY, Shrestha SK, Shrestha MP, Pavlin JA, Gibbons RV et al (2011c) Short report: genetic diversity of Thottapalayam virus, a Hantavirus harbored by the Asian house shrew (Suncus murinus) in Nepal. Am J Trop Med Hyg 85(3):540–545

    Google Scholar 

  • Kariwa H, Yoshimatsu K, Arikawa J (2007a) Hantavirus infection in East Asia. Comp Immunol Microbiol Infect Dis 30(5–6):341–356

    Google Scholar 

  • Kariwa H, Lokugamage K, Lokugamage N, Miyamoto H, Yoshii K, Nakauchi M et al (2007b) A comparative epidemiological study of hantavirus infection in Japan and Far East Russia. Jpn J Vet Res 54(4):145–161

    Google Scholar 

  • Katz G, Williams RJ, Burt MS, de Souza LT, Pereira LE, Mills JN et al (2001) Hantavirus pulmonary syndrome in the State of Sao Paulo, Brazil, 1993–1998. Vector Borne Zoonotic Dis Fall 1(3):181–190

    Google Scholar 

  • Kelt DA, Van Vuren DH, Hafner MS, Danielson BJ, Kelly MJ (2007) Threat of hantavirus pulmonary syndrome to field biologists working with small mammals. Emerg Infect Dis 13(9):1285–1287

    PubMed Central  PubMed  Google Scholar 

  • Khan AS, Spiropoulou CF, Morzunov S, Zaki SR, Kohn MA, Nawas SR et al (1995) Fatal illness associated with a new hantavirus in Louisiana. J Med Virol 46(3):281–286

    CAS  PubMed  Google Scholar 

  • Khan AS, Gaviria M, Rollin PE, Hlady WG, Ksiazek TG, Armstrong LR et al (1996) Hantavirus pulmonary syndrome in Florida: association with the newly identified Black Creek Canal virus. Am J Med 100(1):46–48

    CAS  PubMed  Google Scholar 

  • Kim GR, Lee YT, Park CH (1994) A new natural reservoir of hantavirus: isolation of hantaviruses from lung tissues of bats. Arch Virol 134(1–2):85–95

    CAS  PubMed  Google Scholar 

  • Kimmig P, Silva-Gonzalez R, Backe H, Brockmann S, Oehme R, Ernst E et al (2001) Epidemiology of hantaviruses in Baden-Wurttemberg. Gesundheitswesen 63(2):107–112

    CAS  PubMed  Google Scholar 

  • Klein SL, Marks MA, Li W, Glass GE, Fang LQ, Ma JQ et al (2011) Sex differences in the incidence and case fatality rates from hemorrhagic fever with renal syndrome in China, 2004–2008. Clin Infect Dis 52(12):1414–1421

    PubMed Central  PubMed  Google Scholar 

  • Klempa B, Meisel H, Rath S, Bartel J, Ulrich R, Kruger DH (2003) Occurrence of renal and pulmonary syndrome in a region of northeast Germany where Tula hantavirus circulates. J Clin Microbiol 41(10):4894–4897

    PubMed Central  PubMed  Google Scholar 

  • Klempa B, Fichet-Calvet E, Lecompte E, Auste B, Aniskin V, Meisel H et al (2006) Hantavirus in African wood mouse, Guinea. Emerg Infect Dis 12(5):838–840

    PubMed Central  PubMed  Google Scholar 

  • Klempa B, Fichet-Calvet E, Lecompte E, Auste B, Aniskin V, Meisel H et al (2007) Novel hantavirus sequences in Shrew, Guinea. Emerg Infect Dis 13(3):520–522

    CAS  PubMed Central  PubMed  Google Scholar 

  • Klempa B, Tkachenko EA, Dzagurova TK, Yunicheva YV, Morozov VG, Okulova NM et al (2008) Hemorrhagic fever with renal syndrome caused by 2 lineages of Dobrava hantavirus, Russia. Emerg Infect Dis 14(4):617–625

    PubMed Central  PubMed  Google Scholar 

  • Klempa B, Koivogui L, Sylla O, Koulemou K, Auste B, Kruger DH et al (2010) Serological evidence of human hantavirus infections in Guinea, West Africa. J Infect Dis 201(7):1031–1034

    PubMed  Google Scholar 

  • Klempa B, Witkowski PT, Popugaeva E, Auste B, Koivogui L, Fichet-Calvet E et al (2012a) Sangassou virus, the first hantavirus isolate from Africa, displays genetic and functional properties distinct from those of other murinae-associated hantaviruses. J Virol 86(7):3819–3827

    Google Scholar 

  • Klempa B, Witkowski PT, Popugaeva E, Auste B, Koivogui L, Fichet-Calvet E et al (2012b) Sangassou virus, the first hantavirus isolate from Africa, displays distinct genetic and functional properties in the group of murinae-associated hantaviruses. J Virol 86(7)

    Google Scholar 

  • Klempa B, Avsic-Zupanc T, Clement J, Dzagurova TK, Henttonen H, Heyman P et al (2013a) Complex evolution and epidemiology of Dobrava-Belgrade hantavirus: definition of genotypes and their characteristics. Arch Virol 158(3):521–529

    Google Scholar 

  • Klempa B, Koulemou K, Auste B, Emmerich P, Thome-Bolduan C, Gunther S et al (2013b) Seroepidemiological study reveals regional co-occurrence of Lassa- and Hantavirus antibodies in Upper Guinea, West Africa. Trop Med Int Health 18(3):366–371

    Google Scholar 

  • Klingstrom J, Plyusnin A, Vaheri A, Lundkvist A (2002a) Wild-type Puumala hantavirus infection induces cytokines, C-reactive protein, creatinine, and nitric oxide in cynomolgus macaques. J Virol 76(1):444–449

    Google Scholar 

  • Klingstrom J, Heyman P, Escutenaire S, Sjolander KB, De Jaegere F, Henttonen H et al (2002b) Rodent host specificity of European hantaviruses: evidence of Puumala virus interspecific spillover. J Med Virol 68(4):581–588

    Google Scholar 

  • Klingstrom J, Lindgren T, Ahlm C (2008) Sex-dependent differences in plasma cytokine responses to hantavirus infection. Clin Vaccine Immunol 15(5):885–887

    PubMed Central  PubMed  Google Scholar 

  • Koch J, Brockmann SO, Winter C, Kimmig P, Stark K (2007) Significant increase of hantavirus infections in Germany since the beginning of 2007. Euro Surveill 12(5):E070503 1

    Google Scholar 

  • Koma T, Yoshimatsu K, Taruishi M, Miyashita D, Endo R, Shimizu K et al (2012) Development of a serotyping enzyme-linked immunosorbent assay system based on recombinant truncated hantavirus nucleocapsid proteins for New World hantavirus infection. J Virol Methods 185(1):74–81

    CAS  PubMed  Google Scholar 

  • Kramski M, Achazi K, Klempa B, Kruger DH (2009) Nephropathia epidemica with a 6-week incubation period after occupational exposure to Puumala hantavirus. J Clin Virol 44(1):99–101

    CAS  PubMed  Google Scholar 

  • Krautkrämer E, Grouls S, Stein N, Reiser J, Zeier M (2011) Pathogenic old world hantaviruses infect renal glomerular and tubular cells and induce disassembling of cell-to-cell contacts. J Virol 85(19):9811–9823

    PubMed Central  PubMed  Google Scholar 

  • Krautkramer E, Zeier M (2008) Hantavirus causing hemorrhagic fever with renal syndrome enters from the apical surface and requires decay-accelerating factor (DAF/CD55). J Virol 82(9):4257–4264

    PubMed Central  PubMed  Google Scholar 

  • Krautkramer E, Kruger DH, Zeier M (2012) Recent outbreaks of hantavirus disease in Germany and in the United States. Kidney Int 82(12):1243–1245

    PubMed  Google Scholar 

  • Ksiazek TG, Peters CJ, Rollin PE, Zaki S, Nichol S, Spiropoulou C et al (1995) Identification of a new North American hantavirus that causes acute pulmonary insufficiency. Am J Trop Med Hyg 52(2):117–123

    CAS  PubMed  Google Scholar 

  • Ksiazek TG, Nichol ST, Mills JN, Groves MG, Wozniak A, McAdams S et al (1997) Isolation, genetic diversity, and geographic distribution of Bayou virus (Bunyaviridae: hantavirus). Am J Trop Med Hyg 57(4):445–448

    CAS  PubMed  Google Scholar 

  • Larson RS, Brown DC, Ye C, Hjelle B (2005) Peptide antagonists that inhibit Sin Nombre virus and hantaan virus entry through the beta3-integrin receptor. J Virol 79(12):7319–7326

    CAS  PubMed Central  PubMed  Google Scholar 

  • Lazaro ME, Cantoni GE, Calanni LM, Resa AJ, Herrero ER, Iacono MA et al (2007) Clusters of hantavirus infection, southern Argentina. Emerg Infect Dis 13(1):104–110

    PubMed Central  PubMed  Google Scholar 

  • Le Guenno B (1997) Les Hantavirus. Med Mal Infect 27:703–710

    Google Scholar 

  • Lee HW (1982) Korean hemorrhagic fever. Prog Med Virol 28:96–113

    CAS  PubMed  Google Scholar 

  • Leighton FA, Artsob HA, Chu MC, Olson JG (2001) A serological survey of rural dogs and cats on the southwestern Canadian prairie for zoonotic pathogens. Can J Public Health 92(1):67–71

    CAS  PubMed  Google Scholar 

  • Lin XD, Guo WP, Wang W, Zou Y, Hao ZY, Zhou DJ et al (2012) Migration of norway rats resulted in the worldwide distribution of seoul hantavirus today. J Virol 86(2):972–981

    CAS  PubMed Central  PubMed  Google Scholar 

  • Linard C, Lamarque P, Heyman P, Ducoffre G, Luyasu V, Tersago K et al (2007) Determinants of the geographic distribution of Puumala virus and Lyme borreliosis infections in Belgium. Int J Health Geogr 6:15

    PubMed Central  PubMed  Google Scholar 

  • Linderholm M, Sandstrom T, Rinnstrom O, Groth S, Blomberg A, Tarnvik A (1997) Impaired pulmonary function in patients with hemorrhagic fever with renal syndrome. Clin Infect Dis 25(5):1084–1089

    CAS  PubMed  Google Scholar 

  • Liu X, Jiang B, Bi P, Yang W, Liu Q (2012) Prevalence of haemorrhagic fever with renal syndrome in mainland China: analysis of National Surveillance Data, 2004–2009. Epidemiol Infect 140(5):851–857

    CAS  PubMed  Google Scholar 

  • Lopez N, Padula P, Rossi C, Lazaro ME, Franze-Fernandez MT (1996) Genetic identification of a new hantavirus causing severe pulmonary syndrome in Argentina. Virology 220(1):223–226

    CAS  PubMed  Google Scholar 

  • Luan VD, Yoshimatsu K, Endo R, Taruishi M, Huong VT, Dat DT et al (2012) Studies on hantavirus infection in small mammals captured in southern and central highland area of Vietnam. J Vet Med Sci 74(9):1155–1562

    PubMed  Google Scholar 

  • Luis AD, Douglass RJ, Hudson PJ, Mills JN, Bjornstad ON (2012) Sin Nombre hantavirus decreases survival of male deer mice. Oecologia 169(2):431–439

    PubMed  Google Scholar 

  • MacNeil A, Ksiazek TG, Rollin PE (2011) Hantavirus pulmonary syndrome, United States, 1993–2009. Emerg Infect Dis 17(7):1195–1201

    PubMed Central  PubMed  Google Scholar 

  • Maes P, Klempa B, Clement J, Matthijnssens J, Gajdusek DC, Kruger DH et al (2009) A proposal for new criteria for the classification of hantaviruses, based on S and M segment protein sequences. Infect Genet Evol 9(5):813–820

    CAS  PubMed  Google Scholar 

  • Mailles A, Sin MA, Ducoffre G, Heyman P, Koch J, Zeller H (2005) Larger than usual increase in cases of hantavirus infections in Belgium, France and Germany, June 2005. Euro Surveill 10(7):E050721 4

    Google Scholar 

  • Makary P, Kanerva M, Ollgren J, Virtanen MJ, Vapalahti O, Lyytikainen O (2010) Disease burden of Puumala virus infections, 1995–2008. Epidemiol Infect Epub ahead of print

    Google Scholar 

  • Makela S, Hurme M, Ala-Houhala I, Mustonen J, Koivisto AM, Partanen J et al (2001) Polymorphism of the cytokine genes in hospitalized patients with Puumala hantavirus infection. Nephrol Dial Transplant 16(7):1368–1373

    CAS  PubMed  Google Scholar 

  • Malecki TM, Jillson GP, Thilsted JP, Elrod J, Torrez-Martinez N, Hjelle B (1998) Serologic survey for hantavirus infection in domestic animals and coyotes from New Mexico and northeastern Arizona. J Am Vet Med Assoc 212(7):970–973

    CAS  PubMed  Google Scholar 

  • Markotic A, Nichol ST, Kuzman I, Sanchez AJ, Ksiazek TG, Gagro A et al (2002) Characteristics of Puumala and Dobrava infections in Croatia. J Med Virol 66(4):542–551

    CAS  PubMed  Google Scholar 

  • Markotic A, Hensley L, Daddario K, Spik K, Anderson K, Schmaljohn C (2007) Pathogenic hantaviruses elicit different immunoreactions in THP-1 cells and primary monocytes and induce differentiation of human monocytes to dendritic-like cells. Coll Antropol 31(4):1159–1167

    CAS  PubMed  Google Scholar 

  • Marsac D, Garcia S, Fournet A, Aguirre A, Pino K, Ferres M et al (2011) Infection of human monocyte-derived dendritic cells by ANDES Hantavirus enhances pro-inflammatory state, the secretion of active MMP-9 and indirectly enhances endothelial permeability. Virol J 8:223

    CAS  PubMed Central  PubMed  Google Scholar 

  • Martens H (2000) Serologic study of the prevalence and course of Hantavirus infections in Mecklenburg-Vorpommern. Gesundheitswesen 62(2):71–77

    CAS  PubMed  Google Scholar 

  • Martinez VP, Bellomo C, San Juan J, Pinna D, Forlenza R, Elder M et al (2005) Person-to-person transmission of Andes virus. Emerg Infect Dis 11(12):1848–1853

    PubMed Central  PubMed  Google Scholar 

  • Martinez VP, Bellomo CM, Cacace ML, Suarez P, Bogni L, Padula PJ (2010) Hantavirus pulmonary syndrome in Argentina, 1995–2008. Emerg Infect Dis 16(12):1853–1860

    PubMed Central  PubMed  Google Scholar 

  • Meheretu Y, Cizkova D, Tesikova J, Welegerima K, Tomas Z, Kidane D et al (2012) High diversity of RNA viruses in rodents, Ethiopia. Emerg Infect Dis 18(12):2047–2050

    PubMed Central  PubMed  Google Scholar 

  • Meisel H, Wolbert A, Razanskiene A, Marg A, Kazaks A, Sasnauskas K et al (2006) Development of novel immunoglobulin G (IgG), IgA, and IgM enzyme immunoassays based on recombinant Puumala and Dobrava hantavirus nucleocapsid proteins. Clin Vaccine Immunol 13(12):1349–1357

    CAS  PubMed Central  PubMed  Google Scholar 

  • Mentel R, Bordihn N, Wegner U, Wendel H, Niklasson B (1999) Hantavirus Dobrava infection with pulmonary manifestation. Med Microbiol Immunol 188(1):51–53

    CAS  PubMed  Google Scholar 

  • Mertens M, Wolfel R, Ullrich K, Yoshimatsu K, Blumhardt J, Romer I et al (2009) Seroepidemiological study in a Puumala virus outbreak area in South-East Germany. Med Microbiol Immunol 198(2):83–91

    PubMed  Google Scholar 

  • Mertens M, Hofmann J, Petraityte-Burneikiene R, Ziller M, Sasnauskas K, Friedrich R et al (2011a) Seroprevalence study in forestry workers of a non-endemic region in eastern Germany reveals infections by Tula and Dobrava-Belgrade hantaviruses. Med Microbiol Immunol 200(4):263–268

    Google Scholar 

  • Mertens M, Kindler E, Emmerich P, Esser J, Wagner-Wiening C, Wolfel R et al (2011b) Phylogenetic analysis of Puumala virus subtype Bavaria, characterization and diagnostic use of its recombinant nucleocapsid protein. Virus Genes 43(2):177–191

    Google Scholar 

  • Mertens M, Essbauer SS, Rang A, Schroder J, Splettstoesser WD, Kretzschmar C et al (2011c) Non-human primates in outdoor enclosures: risk for infection with rodent-borne hantaviruses. Vet Microbiol 147(3–4):420–425

    Google Scholar 

  • Mertz GJ, Miedzinski L, Goade D, Pavia AT, Hjelle B, Hansbarger CO et al (2004) Placebo-controlled, double-blind trial of intravenous ribavirin for the treatment of hantavirus cardiopulmonary syndrome in North America. Clin Infect Dis 39(9):1307–1313

    CAS  PubMed  Google Scholar 

  • Miettinen MH, Makela SM, Ala-Houhala IO, Huhtala HS, Koobi T, Vaheri AI et al (2006) Ten-year prognosis of Puumala hantavirus-induced acute interstitial nephritis. Kidney Int 69(11):2043–2048

    Google Scholar 

  • Miettinen MH, Makela SM, Ala-Houhala IO, Huhtala HS, Koobi T, Vaheri AI et al (2009) Tubular proteinuria and glomerular filtration 6 years after puumala hantavirus-induced acute interstitial nephritis. Nephron Clin Pract 112(2):c115–20

    CAS  PubMed  Google Scholar 

  • Milazzo ML, Eyzaguirre EJ, Molina CP, Fulhorst CF (2002) Maporal viral infection in the Syrian golden hamster: a model of hantavirus pulmonary syndrome. J Infect Dis 186(10):1390–1395

    PubMed  Google Scholar 

  • Miyamoto H, Kariwa H, Araki K, Lokugamage K, Hayasaka D, Cui BZ et al (2003) Serological analysis of hemorrhagic fever with renal syndrome (HFRS) patients in Far Eastern Russia and identification of the causative hantavirus genotype. Arch Virol 148(8):1543–1556

    CAS  PubMed  Google Scholar 

  • Morzunov SP, Feldmann H, Spiropoulou CF, Semenova VA, Rollin PE, Ksiazek TG et al (1995) A newly recognized virus associated with a fatal case of hantavirus pulmonary syndrome in Louisiana. J Virol 69(3):1980–1983

    CAS  PubMed Central  PubMed  Google Scholar 

  • Morzunov SP, Rowe JE, Ksiazek TG, Peters CJ, St Jeor SC, Nichol ST (1998) Genetic analysis of the diversity and origin of hantaviruses in Peromyscus leucopus mice in North America. J Virol 72(1):57–64

    CAS  PubMed Central  PubMed  Google Scholar 

  • Muranyi W, Kehm R, Bahr U, Muller S, Handermann M, Darai G et al (2004) Bovine aortic endothelial cells are susceptible to hantavirus infection; a new aspect in hantavirus ecology. Virology 318(1):112–122

    CAS  PubMed  Google Scholar 

  • Mustonen J, Partanen J, Kanerva M, Pietila K, Vapalahti O, Pasternack A et al (1996) Genetic susceptibility to severe course of nephropathia epidemica caused by Puumala hantavirus. Kidney Int 49(1):217–221

    CAS  PubMed  Google Scholar 

  • Mustonen J, Partanen J, Kanerva M, Pietila K, Vapalahti O, Pasternack A et al (1998) Association of HLA B27 with benign clinical course of nephropathia epidemica caused by Puumala hantavirus. Scand J Immunol 47(3):277–279

    CAS  PubMed  Google Scholar 

  • Nemirov K, Leirs H, Lundkvist A, Olsson GE (2010) Puumala hantavirus and Myodes glareolus in northern Europe: no evidence of co-divergence between genetic lineages of virus and host. J Gen Virol 91(Pt 5):1262–1274

    CAS  PubMed  Google Scholar 

  • Nichol ST, Spiropoulou CF, Morzunov S, Rollin PE, Ksiazek TG, Feldmann H et al (1993) Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness. Science 262(5135):914–917

    CAS  PubMed  Google Scholar 

  • Nowotny N (1994) The domestic cat: a possible transmitter of viruses from rodents to man. Lancet 343(8902):921

    CAS  PubMed  Google Scholar 

  • Nowotny N (1996) [Serologic studies of domestic cats for potential human pathogenic virus infections from wild rodents]. Zentralbl Hyg Umweltmed 198(5):452–461

    CAS  PubMed  Google Scholar 

  • Núñez JJ, Fritz CL, Knust B, Buttke D, Enge B, Novak MG, Kramer V, Osadebe L, Messenger S, Albariño CG, Ströher U, Niemela M, Amman BR, Wong D, Manning CR, Nichol ST, Rollin PE, Xia D, Watt JP, Vugia DJ; Yosemite Hantavirus Outbreak Investigation Team (2014) Hantavirus infections among overnight visitors to Yosemite National Park, California, USA, 2012. Emerg Infect Dis 20(3):386–393

    Google Scholar 

  • Olsson GE, Dalerum F, Hornfeldt B, Elgh F, Palo TR, Juto P et al (2003) Human hantavirus infections, Sweden. Emerg Infect Dis 9(11):1395–1401

    Google Scholar 

  • Padula PJ, Edelstein A, Miguel SD, Lopez NM, Rossi CM, Rabinovich RD (1998) Hantavirus pulmonary syndrome outbreak in Argentina: molecular evidence for person-to-person transmission of Andes virus. Virology 241(2):323–330

    CAS  PubMed  Google Scholar 

  • Passaro DJ, Shieh WJ, Hacker JK, Fritz CL, Hogan SR, Fischer M et al (2001) Predominant kidney involvement in a fatal case of hantavirus pulmonary syndrome caused by Sin Nombre virus. Clin Infect Dis 33(2):263–264

    CAS  PubMed  Google Scholar 

  • Pearce-Duvet JM, St Jeor SC, Boone JD, Dearing MD (2006) Changes in sin nombre virus antibody prevalence in deer mice across seasons: the interaction between habitat, sex, and infection in deer mice. J Wildl Dis 42(4):819–824

    PubMed  Google Scholar 

  • Pergam SA, Schmidt DW, Nofchissey RA, Hunt WC, Harford AH, Goade DE (2009) Potential renal sequelae in survivors of hantavirus cardiopulmonary syndrome. Am J Trop Med Hyg 80(2):279–285

    PubMed Central  PubMed  Google Scholar 

  • Pettersson L, Boman J, Juto P, Evander M, Ahlm C (2008) Outbreak of Puumala virus infection, Sweden. Emerg Infect Dis 14(5):808–810

    PubMed Central  PubMed  Google Scholar 

  • Piechotowski I, Brockmann SO, Schwarz C, Winter CH, Ranft U, Pfaff G (2008) Emergence of hantavirus in South Germany: rodents, climate and human infections. Parasitol Res 103 (Suppl 1):131–137

    Google Scholar 

  • Pilaski J, Feldmann H, Morzunov S, Rollin PE, Ruo SL, Lauer B et al (1994) Genetic identification of a new Puumala virus strain causing severe hemorrhagic fever with renal syndrome in Germany. J Infect Dis 170(6):1456–1462

    CAS  PubMed  Google Scholar 

  • Plyusnin A (2002) Genetics of hantaviruses: implications to taxonomy. Arch Virol 147(4):665–682

    CAS  PubMed  Google Scholar 

  • Plyusnin A, Morzunov SP (2001) Virus evolution and genetic diversity of hantaviruses and their rodent hosts. Curr Top Microbiol Immunol 256:47–75

    CAS  PubMed  Google Scholar 

  • Plyusnin A, Vapalahti O, Lankinen H, Lehvaslaiho H, Apekina N, Myasnikov Y et al (1994) Tula virus: a newly detected hantavirus carried by European common voles. J Virol 68(12):7833–7839

    CAS  PubMed Central  PubMed  Google Scholar 

  • Plyusnin A, Vapalahti O, Vaheri A (1996) Hantaviruses: genome structure, expression and evolution. J Gen Virol 77(Pt 11):2677–2687

    CAS  PubMed  Google Scholar 

  • Plyusnina A, Deter J, Charbonnel N, Cosson JF, Plyusnin A (2007) Puumala and Tula hantaviruses in France. Virus Res 129(1):58–63

    CAS  PubMed  Google Scholar 

  • Plyusnina A, Ferenczi E, Racz GR, Nemirov K, Lundkvist A, Vaheri A et al (2009) Co-circulation of three pathogenic hantaviruses: Puumala, Dobrava, and Saaremaa in Hungary. J Med Virol 81(12):2045–2052

    PubMed  Google Scholar 

  • Plyusnin A, Beauty BJ, Elliott RM, Goldback R, Kormelink R, Lundkvist A et al (2011) Ninth report of the international committee on taxonomy of viruses. Elsevier, San Diego

    Google Scholar 

  • Plyusnina A, Heyman P, Baert K, Stuyck J, Cochez C, Plyusnin A (2012) Genetic characterization of seoul hantavirus originated from norway rats (Rattus norvegicus) captured in Belgium. J Med Virol 84(8):1298–1303

    PubMed  Google Scholar 

  • Poeppl W, Tobudic S, Winkler HM, Faas A, Mooseder G, Burgmann H (2012) Cross-sectional survey of the seroprevalence of Puumala hantavirus in Austria. Vector Borne Zoonotic Dis 12(8):709–711

    PubMed  Google Scholar 

  • Raftery MJ, Kraus AA, Ulrich R, Kruger DH, Schonrich G (2002) Hantavirus infection of dendritic cells. J Virol 76(21):10724–10733

    CAS  PubMed Central  PubMed  Google Scholar 

  • Ramos MM, Overturf GD, Crowley MR, Rosenberg RB, Hjelle B (2001) Infection with Sin Nombre hantavirus: clinical presentation and outcome in children and adolescents. Pediatrics 108(2):E27

    CAS  PubMed  Google Scholar 

  • Ramsden C, Holmes EC, Charleston MA (2009) Hantavirus evolution in relation to its rodent and insectivore hosts: no evidence for codivergence. Mol Biol Evol 26(1):143–153

    CAS  PubMed  Google Scholar 

  • Rasche FM, Uhel B, Kruger DH, Karges W, Czock D, Hampl W et al (2004) Thrombocytopenia and acute renal failure in Puumala hantavirus infections. Emerg Infect Dis 10(8):1420–1425

    PubMed Central  PubMed  Google Scholar 

  • Ravkov EV, Rollin PE, Ksiazek TG, Peters CJ, Nichol ST (1995) Genetic and serologic analysis of Black Creek Canal virus and its association with human disease and Sigmodon hispidus infection. Virology 210(2):482–489

    CAS  PubMed  Google Scholar 

  • Razzauti M, Plyusnina A, Henttonen H, Plyusnin A (2008) Accumulation of point mutations and reassortment of genomic RNA segments are involved in the microevolution of Puumala hantavirus in a bank vole (Myodes glareolus) population. J Gen Virol 89(Pt 7):1649–1660

    CAS  PubMed  Google Scholar 

  • Razzauti M, Plyusnina A, Sironen T, Henttonen H, Plyusnin A (2009) Analysis of Puumala hantavirus in a bank vole population in northern Finland: evidence for co-circulation of two genetic lineages and frequent reassortment between strains. J Gen Virol 90(Pt 8):1923–1931

    CAS  PubMed  Google Scholar 

  • Razzauti M, Plyusnina A, Niemimaa J, Henttonen H, Plyusnin A (2012) Co-circulation of two Puumala hantavirus lineages in Latvia: a Russian lineage described previously and a novel Latvian lineage. J Med Virol 84(2):314–318

    PubMed  Google Scholar 

  • Reusken C, Heyman P (2013) Factors driving hantavirus emergence. Europe Curr Opin Virol 3(1):92–99

    Google Scholar 

  • Rhodes LV 3rd, Huang C, Sanchez AJ, Nichol ST, Zaki SR, Ksiazek TG et al (2000) Hantavirus pulmonary syndrome associated with Monongahela virus, Pennsylvania. Emerg Infect Dis 6(6):616–621

    PubMed Central  PubMed  Google Scholar 

  • Rieger MA, Nübling M, Hofmann F (2005) Berufliche Gefährdung der Landwirte durch Hantaviren. Schriftenreihe der Bundesanstalt für Arbeitsschutz und Arbeitsmedizin

    Google Scholar 

  • Rippe B (2006) Is there an increased long-term risk of hypertension and renal impairment after Puumala virus-induced nephropathy? Kidney Int 69(11):1930–1931

    CAS  PubMed  Google Scholar 

  • Roehr B (2012) US officials warn 39 countries about risk of hantavirus among travellers to Yosemite. BMJ 345:e6054

    PubMed  Google Scholar 

  • Rollin PE, Ksiazek TG, Elliott LH, Ravkov EV, Martin ML, Morzunov S et al (1995) Isolation of black creek canal virus, a new hantavirus from Sigmodon hispidus in Florida. J Med Virol 46(1):35–39

    CAS  PubMed  Google Scholar 

  • Rose AM, Vapalahti O, Lyytikainen O, Nuorti P (2003) Patterns of Puumala virus infection in Finland. Euro Surveill 8(1):9–13

    CAS  PubMed  Google Scholar 

  • Sariguzel N, Hofmann J, Canpolat AT, Turk A, Ettinger J, Atmaca D et al (2012) Dobrava hantavirus infection complicated by panhypopituitarism, Istanbul, Turkey, 2010. Emerg Infect Dis 18(7):1180–1183

    CAS  PubMed Central  PubMed  Google Scholar 

  • Sauvage F, Penalba C, Vuillaume P, Boue F, Coudrier D, Pontier D et al (2002) Puumala hantavirus infection in humans and in the reservoir host, Ardennes region, France. Emerg Infect Dis 8(12):1509–1511

    CAS  PubMed Central  PubMed  Google Scholar 

  • Schlegel M, Klempa B, Auste B, Bemmann M, Schmidt-Chanasit J, Buchner T et al (2009) Dobrava-belgrade virus spillover infections, Germany. Emerg Infect Dis 15(12):2017–2020

    PubMed Central  PubMed  Google Scholar 

  • Schlegel M, Kindler E, Essbauer SS, Wolf R, Thiel J, Groschup MH et al (2012a) Tula virus infections in the Eurasian water vole in Central Europe. Vector Borne Zoonotic Dis 12(6):503–513

    Google Scholar 

  • Schlegel M, Radosa L, Rosenfeld UM, Schmidt S, Triebenbacher C, Lohr PW et al (2012b) Broad geographical distribution and high genetic diversity of shrew-borne Seewis hantavirus in Central Europe. Virus Genes 45(1):48–55

    Google Scholar 

  • Schmidt-Chanasit J, Essbauer S, Petraityte R, Yoshimatsu K, Tackmann K, Conraths FJ et al (2010) Extensive host sharing of central European Tula virus. J Virol 84(1):459–474

    CAS  PubMed Central  PubMed  Google Scholar 

  • Schultze D, Lundkvist A, Blauenstein U, Heyman P (2002) Tula virus infection associated with fever and exanthema after a wild rodent bite. Eur J Clin Microbiol Infect Dis 21(4):304–306

    CAS  PubMed  Google Scholar 

  • Schutt M, Meisel H, Kruger DH, Ulrich R, Dalhoff K, Dodt C (2004) Life-threatening Dobrava hantavirus infection with unusually extended pulmonary involvement. Clin Nephrol 62(1):54–57

    CAS  PubMed  Google Scholar 

  • Settergren B, Ahlm C, Alexeyev O, Billheden J, Stegmayr B (1997) Pathogenetic and clinical aspects of the renal involvement in hemorrhagic fever with renal syndrome. Ren Fail 19(1):1–14

    CAS  PubMed  Google Scholar 

  • Siffczyk C, Bradt K, Dreesman J, Krone B, Koch J, Ulrich RG (2006) Hantavirus-Erkrankungen: Niedersächsische Fall-Kontroll-Studie zum gehäuften Auftreten in den Jahren 2004 und 2005. Epid Bull 2:15–16

    Google Scholar 

  • Sironen T, Klingstrom J, Vaheri A, Andersson LC, Lundkvist A, Plyusnin A (2008) Pathology of Puumala hantavirus infection in macaques. PLoS ONE 3(8):e3035

    PubMed Central  PubMed  Google Scholar 

  • Song JW, Baek LJ, Nagle JW, Schlitter D, Yanagihara R (1996) Genetic and phylogenetic analyses of hantaviral sequences amplified from archival tissues of deer mice (Peromyscus maniculatus nubiterrae) captured in the eastern United States. Arch Virol 141(5):959–967

    CAS  PubMed  Google Scholar 

  • Song JY, Chun BC, Kim SD, Baek LJ, Kim SH, Sohn JW et al (2006) Epidemiology of hemorrhagic fever with renal syndrome in endemic area of the Republic of Korea, 1995–1998. J Korean Med Sci 21(4):614–620

    PubMed Central  PubMed  Google Scholar 

  • Song JW, Kang HJ, Song KJ, Truong TT, Bennett SN, Arai S et al (2007a) Newfound hantavirus in Chinese mole shrew, Vietnam. Emerg Infect Dis 13(11):1784–1787

    Google Scholar 

  • Song JW, Gu SH, Bennett SN, Arai S, Puorger M, Hilbe M et al (2007b) Seewis virus, a genetically distinct hantavirus in the Eurasian common shrew (Sorex araneus). Virol J 4:114

    Google Scholar 

  • Song JW, Kang HJ, Gu SH, Moon SS, Bennett SN, Song KJ et al (2009) Characterization of Imjin virus, a newly isolated hantavirus from the Ussuri white-toothed shrew (Crocidura lasiura). J Virol 83(12):6184–6191

    CAS  PubMed Central  PubMed  Google Scholar 

  • Sumibcay L, Kadjo B, Gu SH, Kang HJ, Lim BK, Cook JA et al (2012) Divergent lineage of a novel hantavirus in the banana pipistrelle (Neoromicia nanus) in Cote d’Ivoire. Virol J 9:34

    CAS  PubMed Central  PubMed  Google Scholar 

  • Temonen M, Vapalahti O, Holthofer H, Brummer-Korvenkontio M, Vaheri A, Lankinen H (1993) Susceptibility of human cells to Puumala virus infection. J Gen Virol 74(Pt 3):515–518

    PubMed  Google Scholar 

  • Tersago K, Schreurs A, Linard C, Verhagen R, Van Dongen S, Leirs H (2008) Population, environmental, and community effects on local bank vole (Myodes glareolus) Puumala virus infection in an area with low human incidence. Vector Borne Zoonotic Dis 8(2):235–244

    CAS  PubMed  Google Scholar 

  • Tersago K, Verhagen R, Servais A, Heyman P, Ducoffre G, Leirs H (2009) Hantavirus disease (nephropathia epidemica) in Belgium: effects of tree seed production and climate. Epidemiol Infect 137(2):250–256

    CAS  PubMed  Google Scholar 

  • Tersago K, Verhagen R, Vapalahti O, Heyman P, Ducoffre G, Leirs H (2011) Hantavirus outbreak in Western Europe: reservoir host infection dynamics related to human disease patterns. Epidemiol Infect 139(3):381–390

    CAS  PubMed  Google Scholar 

  • Tersago K, Crespin L, Verhagen R, Leirs H (2012) Impact of Puumala virus infection on maturation and survival in bank voles: a capture-mark-recapture analysis. J Wildl Dis 48(1):148–156

    PubMed  Google Scholar 

  • Tkachenko EA, Lee HW (1991) Etiology and epidemiology of hemorrhagic fever with renal syndrome. Kidney Int Suppl 35:54–61

    Google Scholar 

  • Toro J, Vega JD, Khan AS, Mills JN, Padula P, Terry W et al (1998) An outbreak of hantavirus pulmonary syndrome, Chile, 1997. Emerg Infect Dis 4(4):687–694

    CAS  PubMed Central  PubMed  Google Scholar 

  • Torrez-Martinez N, Bharadwaj M, Goade D, Delury J, Moran P, Hicks B et al (1998) Bayou virus-associated hantavirus pulmonary syndrome in Eastern Texas: identification of the rice rat, Oryzomys palustris, as reservoir host. Emerg Infect Dis 4(1):105–111

    CAS  PubMed Central  PubMed  Google Scholar 

  • Turcinov D, Puljiz I, Markotic A, Kuzman I, Begovac J (2013) Clinical and laboratory findings in patients with oliguric and non-oliguric hantavirus haemorrhagic fever with renal syndrome: an analysis of 128 patients. Clin Microbiol Infect 19(7):674–679

    Google Scholar 

  • Ulrich RG, Schmidt-Chanasit J, Schlegel M, Jacob J, Pelz HJ, Mertens M et al (2008) Network “Rodent-borne pathogens” in Germany: LONGITUDINAL studies on the geographical distribution and prevalence of hantavirus infections. Parasitol Res 103(Suppl 1):121–129

    Google Scholar 

  • Vapalahti K, Paunio M, Brummer-Korvenkontio M, Vaheri A, Vapalahti O (1999) Puumala virus infections in Finland: increased occupational risk for farmers. Am J Epidemiol 149(12):1142–1151

    CAS  PubMed  Google Scholar 

  • Vapalahti O, Lundkvist A, Kukkonen SK, Cheng Y, Gilljam M, Kanerva M et al (1996) Isolation and characterization of Tula virus, a distinct serotype in the genus Hantavirus, family Bunyaviridae. J Gen Virol 77(Pt 12):3063–3067

    CAS  PubMed  Google Scholar 

  • Vapalahti O, Mustonen J, Lundkvist A, Henttonen H, Plyusnin A, Vaheri A (2003) Hantavirus infections. Europe Lancet Infect Dis 3(10):653–661

    Google Scholar 

  • Vapalahti K, Virtala AM, Vaheri A, Vapalahti O (2010) Case-control study on Puumala virus infection: smoking is a risk factor. Epidemiol Infect 138(4):576–584

    CAS  PubMed  Google Scholar 

  • Vial PA, Valdivieso F, Mertz G, Castillo C, Belmar E, Delgado I et al (2006) Incubation period of hantavirus cardiopulmonary syndrome. Emerg Infect Dis 12(8):1271–1273

    PubMed Central  PubMed  Google Scholar 

  • Wang M, Wang J, Wang T, Li J, Hui L, Ha X (2013) Thrombocytopenia as a predictor of severe acute kidney injury in patients with Hantaan virus infections. PLoS ONE 8(1):e53236

    CAS  PubMed Central  PubMed  Google Scholar 

  • Weiss S, Witkowski PT, Auste B, Nowak K, Weber N, Fahr J et al (2012) Hantavirus in bat, Sierra Leone. Emerg Infect Dis 18(1):159–161

    PubMed Central  PubMed  Google Scholar 

  • Wells RM, Sosa Estani S, Yadon ZE, Enria D, Padula P, Pini N et al (1997) An unusual hantavirus outbreak in southern Argentina: person-to-person transmission? Hantavirus Pulmonary Syndrome Study Group for Patagonia. Emerg Infect Dis 3(2):171–174

    CAS  PubMed Central  PubMed  Google Scholar 

  • Winter CH, Brockmann SO, Piechotowski I, Alpers K, an der Heiden M, Koch J et al (2009) Survey and case-control study during epidemics of Puumala virus infection. Epidemiol Infect 137(10):1479–1485

    CAS  PubMed  Google Scholar 

  • Xiao SY, Diglisic G, Avsic-Zupanc T, LeDuc JW (1993a) Dobrava virus as a new Hantavirus: evidenced by comparative sequence analysis. J Med Virol 39(2):152–155

    Google Scholar 

  • Xiao SY, Spik KW, Li D, Schmaljohn CS (1993b) Nucleotide and deduced amino acid sequences of the M and S genome segments of two Puumala virus isolates from Russia. Virus Res 30(1):97–103

    Google Scholar 

  • Yanagihara R, Amyx HL, Lee PW, Asher DM, Gibbs CJ Jr, Gajdusek DC (1988) Experimental hantavirus infection in nonhuman primates. Arch Virol 101(1–2):125–130

    CAS  PubMed  Google Scholar 

  • Yang ZQ, Yu SY, Nie J, Chen Q, Li ZF, Liu YX et al (2004) Prevalence of hemorrhagic fever with renal syndrome virus in domestic pigs: an epidemiological investigation in Shandong province. Di Yi Jun Yi Da Xue Xue Bao 24(11):1283–1286

    PubMed  Google Scholar 

  • Yashina LN, Patrushev NA, Ivanov LI, Slonova RA, Mishin VP, Kompanez GG et al (2000) Genetic diversity of hantaviruses associated with hemorrhagic fever with renal syndrome in the far east of Russia. Virus Res 70(1–2):31–44

    CAS  PubMed  Google Scholar 

  • Yashina LN, Abramov SA, Gutorov VV, Dupal TA, Krivopalov AV, Panov VV et al (2010) Seewis virus: phylogeography of a shrew-borne hantavirus in Siberia, Russia. Vector Borne Zoonotic Dis 10(6):585–591

    PubMed Central  PubMed  Google Scholar 

  • Young JC, Hansen GR, Graves TK, Deasy MP, Humphreys JG, Fritz CL et al (2000) The incubation period of hantavirus pulmonary syndrome. Am J Trop Med Hyg 62(6):714–717

    CAS  PubMed  Google Scholar 

  • Zaki SR, Greer PW, Coffield LM, Goldsmith CS, Nolte KB, Foucar K et al (1995) Hantavirus pulmonary syndrome. Pathogenesis of an emerging infectious disease. Am J Pathol 146(3):552–579

    CAS  PubMed Central  PubMed  Google Scholar 

  • Zeier M, Handermann M, Bahr U, Rensch B, Muller S, Kehm R et al (2005) New ecological aspects of hantavirus infection: a change of a paradigm and a challenge of prevention-a review. Virus Genes 30(2):157–180

    CAS  PubMed  Google Scholar 

  • Zeller HG, Karabatsos N, Calisher CH, Digoutte JP, Cropp CB, Murphy FA et al (1989) Electron microscopic and antigenic studies of uncharacterized viruses. II. Evidence suggesting the placement of viruses in the family Bunyaviridae. Arch Virol 108(3–4):211–227

    CAS  PubMed  Google Scholar 

  • Zhang Y, Li X, Tang J (1995) Observational and experimental studies on relationship between domestic pigs and epidemic hemorrhagic fever investigation. Zhonghua Yu Fang Yi Xue Za Zhi 29(6):344–347

    CAS  PubMed  Google Scholar 

  • Zhang YZ, Zou Y, Fu ZF, Plyusnin A (2010) Hantavirus infections in humans and animals, China. Emerg Infect Dis 16(8):1195–1203

    PubMed Central  PubMed  Google Scholar 

  • Zhang X, Chen HY, Zhu LY, Zeng LL, Wang F, Li QG et al (2011) Comparison of Hantaan and Seoul viral infections among patients with hemorrhagic fever with renal syndrome (HFRS) in Heilongjiang, China. Scand J Infect Dis 43(8):632–641

    PubMed  Google Scholar 

  • Zoller L, Faulde M, Meisel H, Ruh B, Kimmig P, Schelling U et al (1995) Seroprevalence of hantavirus antibodies in Germany as determined by a new recombinant enzyme immunoassay. Eur J Clin Microbiol Infect Dis 14(4):305–313

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Virology & Rickettsiology, Bundeswehr Institute of Microbiology, Neuherbergstr. 11, 80937, Munich, Germany

    Sandra S. Essbauer

  2. Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120, Heidelberg, Germany

    Ellen Krautkrämer

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  1. Sandra S. Essbauer
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Correspondence to Sandra S. Essbauer .

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  1. Dept. of Infectiology, Bavarian Health and Food Safety Authority, Oberschleißheim, Bayern, Germany

    Andreas Sing

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Essbauer, S., Krautkrämer, E. (2015). Hantaviruses—Infections, Epidemiology and Hosts. In: Sing, A. (eds) Zoonoses - Infections Affecting Humans and Animals. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9457-2_30

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