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Bio-Inspired Silicon-Based Materials pp 27–37Cite as

Protease-Mediated Hydrolysis and Condensation of Tetra- and Trialkoxysilanes

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Part of the book series: Advances in Silicon Science ((ADSS,volume 5))

Abstract

Silica is a common material with uses in a diverse range of products. New methods for producing silica are always being developed. In the past 15 years biological and bio-inspired approaches for silica production have gained momentum. One of the challenges in designing new materials is developing new methods for their production and gaining a complete understanding of all of the processing parameters. We have been studying the interaction(s) between enzymes and organically modified alkoxysilanes in an attempt to determine the kinetics of hydrolysis and condensation, as well as to determine a general reaction mechanism. We believe that the nature of the enzyme (i.e. mode of catalysis, active site, and secondary interactions) contributes to the ability of any given enzyme to act as a catalyst for the production of silica-based materials.

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Acknowledgements

The authors would like to thank Razvan Simionescu (Brock University) for assistance in acquiring NMR spectra. Funding for these projects was provided by Brock University, Natural Science and Engineering Research Council (NSERC), and the Ontario Partnership for Industrialization and Commercialization (OPIC). MBF was supported through graduate scholarships from the Ontario Scholarship (OGS), the Ontario Graduate Scholarship in Science and Technology (OGSST) and the Queen Elizabeth II Graduate Scholarship in Science and Technology (QEII-GSST) programs.

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Authors and Affiliations

  1. Department of Chemistry, Centre for Biotechnology, Brock University, 500 Glenridge Avenue, L2S 3A1, St. Catharines, ON, Canada

    Mark B. Frampton & Paul M. Zelisko

Authors
  1. Mark B. Frampton
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  2. Paul M. Zelisko
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Correspondence to Paul M. Zelisko .

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Editors and Affiliations

  1. Department of Chemistry and Centre for Biotechnology, Brock University, St. Catharines, Ontario, Canada

    Paul M. Zelisko

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Frampton, M., Zelisko, P. (2014). Protease-Mediated Hydrolysis and Condensation of Tetra- and Trialkoxysilanes. In: Zelisko, P. (eds) Bio-Inspired Silicon-Based Materials. Advances in Silicon Science, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9439-8_3

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