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Senescence in Oncogenesis: From Molecular Mechanisms to Therapeutic Opportunities

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Stress Response Pathways in Cancer

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Abstract

Somatic non stem cells show a spontaneous decline in growth rate in continuous culture related to an increasing number of population doublings, eventually terminating in a quiescent but viable state now known as replicative senescence. These cells show clear and distinctive morphological, physiological and biochemical characteristics. Moreover, the senescent phenotype is associated with a typical gene-expression profile. Similar behaviour has since then been observed in a wide variety of normal cells, and it is now widely accepted that normal somatic cells have an intrinsically limited proliferative lifespan, even under ideal growth conditions. Cells displaying characteristics of senescent cells, however, can be also observed in response to other stimuli, such as oncogenic stress, DNA damage or cytotoxic drugs. These non-proliferative characteristics prompted the scientists to look for therapies that can induce the senescent phenotype in tumor cells as therapeutic approach.

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Acknowledgements

AC lab is supported by grants to from the Spanish Ministry of Economy and Competitivity, ISCIII (Fis: PI12/00137, RTICC: RD12/0036/0028), Consejeria de Ciencia e InnovaciĂłn (CTS-6844 and CTS-1848) and Consejeria de Salud of the Junta de Andalucia (PI-0135-2010 and PI-0306-2012). SM-G has been supported by a fellowship Juan de la Cierva from the Spanish Ministry of Economy and Competitivity.

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  1. Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocio, Consejo Superior de Investigaciones Cientificas (CSIC), Universidad de Sevilla, Avda. Manuel Siurot s/n, 41013, Sevilla, Spain

    Sandra Muñoz-Galvan & Amancio Carnero

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Correspondence to Amancio Carnero .

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  1. Dept. of Pharmacology and Toxicology, Univ. of Arizona, College of Pharm. & The Univ. of Arizona Cancer Ctr., Tucson, Arizona, USA

    Georg T. Wondrak

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Muñoz-Galvan, S., Carnero, A. (2015). Senescence in Oncogenesis: From Molecular Mechanisms to Therapeutic Opportunities. In: Wondrak, G. (eds) Stress Response Pathways in Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9421-3_7

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