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Regulation of Integrin Activity by Phosphorylation

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I Domain Integrins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 819))

Abstract

Integrins are heterodimeric complex type I membrane proteins involved in cellular adhesion and signaling. They exist as inactive molecules in resting cells, and need activation to become adhesive. Although much is known about their structure, and a large number of interacting molecules have been described, we still only partially understand how their activities are regulated. In this review we focus on the leukocyte-specific β2—integrins and, specifically, on the role of integrin phosphorylation in the regulation of activity. Phosphorylation reactions can be fast and reversible, thus enabling strictly directed regulatory activities both time-wise and locally in specific regions of the plasma membrane in different leukocytes.

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Authors and Affiliations

  1. Division of Biochemistry and Biotechnology, Department of Biosciences, University of Helsinki, Viikinkaari 5, 00014, Helsinki, Finland

    Carl G. Gahmberg, Mikaela Grönholm & Liisa M. Uotila

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  1. Carl G. Gahmberg
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  2. Mikaela Grönholm
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  3. Liisa M. Uotila
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Correspondence to Carl G. Gahmberg .

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  1. University of Bergen, Bergen, Norway

    Donald Gullberg

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Gahmberg, C.G., Grönholm, M., Uotila, L.M. (2014). Regulation of Integrin Activity by Phosphorylation. In: Gullberg, D. (eds) I Domain Integrins. Advances in Experimental Medicine and Biology, vol 819. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9153-3_6

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