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eIF4E and Its Binding Proteins

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Book cover Translation and Its Regulation in Cancer Biology and Medicine

Abstract

The link between protein synthesis and cancer was first suggested by Pianese in 1896, who observed that malignant cells contain larger and more numerous nucleoli than normal cells. Yet the role of translation in cancer biology has been largely overlooked in comparison with transcription. Nearly one century elapsed before the first report that ascribed oncogenic properties to a translation initiation factor was published. That factor is the eukaryotic translation initiation factor 4E (eIF4E). eIF4E binds the mRNA 5′ end and is critical for its translation. It has received much attention for its important biological functions, as well as for its involvement in cancer development and progression. Indeed, eIF4E possesses proto-oncogenic properties as its overexpression or hyperactivation leads to tumorigenesis. Increased levels of eIF4E are detected in as many as 30 % of human cancers across a wide variety of sites including head and neck, bladder, colon, breast, prostate, lung, and blood. In several studies, eIF4E overexpression or activation has been associated with poor disease prognosis. This chapter reviews the current knowledge regarding function, activity and regulation of eIF4E, as well as its binding partners, in relation to cancer etiology and pathogenesis.

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Notes

  1. 1.

    Hereafter, percentages indicate the frequency of mutations in human cancers according to COSMIC database

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Acknowledgments

We are very grateful to Dr. Nadeem Siddiqui (GCRC-McGill University) for his helpful insights on eIF4E structure and function and Dr. Armen Parsyan for editing this manuscript. This work was supported by The Susan G. Komen Breast Cancer Foundation (IIR12224057), the Canadian Cancer Society (2010-700377) and the Canadian Institutes of Health Research (MOP-7214). N.S. is a Howard Hughes Medical Institute International Scholar. N.R. was supported by scholarships from the Fonds de la Recherche en Santé du Québec (20874), the Canadian Institutes of Health Research (220151) and the Vanier Canada Graduate Scholarship program (267839).

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  1. Department of Biochemistry and Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada

    Nathaniel Robichaud & Nahum Sonenberg

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  1. Nathaniel Robichaud
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Correspondence to Nathaniel Robichaud .

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  1. Surgery, McGill University, Montreal, Québec, Canada

    Armen Parsyan

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Robichaud, N., Sonenberg, N. (2014). eIF4E and Its Binding Proteins. In: Parsyan, A. (eds) Translation and Its Regulation in Cancer Biology and Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9078-9_4

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