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Cancers of the Respiratory System

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Translation and Its Regulation in Cancer Biology and Medicine

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Abstract

Malignancies of the respiratory system are represented by very prevalent and lethal lung cancer. Lung cancer is the leading cause of cancer deaths worldwide. Thus, developing effective targeted therapies that exploit our expanding knowledge of the molecular biology of the disease is essential. Among these, activated oncogenic signaling and its downstream target, the translation machinery, appear to be key players in the etiology and pathogenesis of lung cancer. Various hubs of translation appear to be involved, including proto-oncogene eIF4E, its suppressor proteins 4E-BPs, tumor suppressor PDCD4 and others. Based on the knowledge of the pathogenic role of these proteins, elegant therapeutic strategies are being developed that directly target these proteins. Here, we will focus our attention on aberrations in the translation machinery, its regulation and therapeutic targeting in lung cancer. We will also discuss interesting findings regarding the role of the translation machinery in mesothelioma of the pleura.

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References

  • Bae SY, Kim GD, Jeon JE, Shin J, Lee SK (2013) Anti-proliferative effect of (19Z)-halichondramide, a novel marine macrolide isolated from the sponge Chondrosia corticata, is associated with G2/M cell cycle arrest and suppression of mTOR signaling in human lung cancer cells. Toxicol In Vitro 27:694–699

    Article  PubMed  CAS  Google Scholar 

  • Bauer C, Diesinger I, Brass N, Steinhart H, Iro H, Meese EU (2001) Translation initiation factor eIF-4G is immunogenic, overexpressed, and amplified in patients with squamous cell lung carcinoma. Cancer 92:822–829

    Article  PubMed  CAS  Google Scholar 

  • Bauer C, Brass N, Diesinger I, Kayser K, Grasser FA, Meese E (2002) Overexpression of the eukaryotic translation initiation factor 4G (eIF4G-1) in squamous cell lung carcinoma. Int J Cancer 98:181–185

    Article  PubMed  CAS  Google Scholar 

  • Brown CJ, Lim JJ, Leonard T, Lim HC Chia CS, Verma CS, Lane DP (2011) Stabilizing the eIF4G1 alpha-helix increases its binding affinity with eIF4E: implications for peptidomimetic design strategies. J Mol Biol 405:736–753

    Article  PubMed  CAS  Google Scholar 

  • Buttitta F, Martella C, Barassi F, Felicioni L, Salvatore S, Rosini S, D’Antuono T, Chella A, ­Mucilli F, Sacco R et al (2005) Int6 expression can predict survival in early-stage non-small cell lung cancer patients. Clin Cancer Res 11:3198–3204

    Article  PubMed  CAS  Google Scholar 

  • Byun HO, Han NK, Lee HJ, Kim KB, Ko YG, Yoon G, Lee YS, Hong SI, Lee JS (2009) Cathepsin D and eukaryotic translation elongation factor 1 as promising markers of cellular senescence. Cancer Res 69:4638–4647

    Article  PubMed  CAS  Google Scholar 

  • Cappuzzo F, Varella-Garcia M, Rossi E, Gajapathy S, Valente M, Drabkin H, Gemmill R (2009) MYC and EIF3H coamplification significantly improve response and survival of non-small cell lung cancer patients (NSCLC) treated with gefitinib. J Thorac Oncol; Off Publ Int Assoc Study of Lung Cancer 4:472–478

    Google Scholar 

  • CCS (2013) Canadian Cancer Society’s Advisory Committee on Cancer Statistics. Canadian cancer statistics 2013. Canadian Cancer Society, Toronto

    Google Scholar 

  • CDC/NCI (2013) U.S. Cancer Statistics Working Group. United States cancer statistics: 1999–2010 incidence and mortality web-based report. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention and National Cancer Institute, Atlanta. http://www.cdc.gov/uscs. Accessed 1 Feb 2014

  • Cedres S, Montero MA, Martinez P, Martinez A, Rodriguez-Freixinos V, Torrejon D, Gabaldon A, Salcedo M, Ramon YCS, Felip E (2012) Exploratory analysis of activation of PTEN-PI3K pathway and downstream proteins in malignant pleural mesothelioma (MPM). Lung Cancer 77:192–198

    Article  PubMed  CAS  Google Scholar 

  • Chang SH, Kim JE, Lee JH, Minai-Tehrani A, Han K, Chae C, Cho YH, Yun JH, Park K, Kim YS et al (2013) Aerosol delivery of eukaryotic translation initiation factor 4E-binding protein 1 effectively suppresses lung tumorigenesis in K-rasLA1 mice. Cancer Gene Ther 20:331–335

    Article  PubMed  CAS  Google Scholar 

  • Chao SK, Lin J, Brouwer-Visser J, Smith AB 3rd, Horwitz, SB, McDaid HM (2011) Resistance to discodermolide, a microtubule-stabilizing agent and senescence inducer, is 4E-BP1-dependent. Proc Natl Acad Sci U S A 108:391–396

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Chen Y, Knosel T, Kristiansen G, Pietas A, Garber ME, Matsuhashi S, Ozaki I, Petersen I (2003) Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis. J Pathol 200:640–646

    Article  PubMed  CAS  Google Scholar 

  • Chen L, Tian G, Shao C, Cobos E, Gao W (2010) Curcumin modulates eukaryotic initiation factors in human lung adenocarcinoma epithelial cells. Mol Biol Rep 37:3105–3110

    Article  PubMed  CAS  Google Scholar 

  • Chen CY, Fang HY, Chiou SH, Yi SE, Huang CY, Chiang SF, Chang HW, Lin TY, Chiang IP, Chow KC (2011) Sumoylation of eukaryotic elongation factor 2 is vital for protein stability and anti-apoptotic activity in lung adenocarcinoma cells. Cancer Sci 102:1582–1589

    Article  PubMed  CAS  Google Scholar 

  • Comtesse N, Keller A, Diesinger I, Bauer C, Kayser K, Huwer H, Lenhof HP, Meese E (2007) Frequent overexpression of the genes FXR1, CLAPM1 and EIF4G located on amplicon 3q26–27 in squamous cell carcinoma of the lung. Int J Cancer J Int Cancer 120:2538–2544

    Article  CAS  Google Scholar 

  • Cooper WA, Lam DC, O’Toole SA, Minna JD (2013) Molecular biology of lung cancer. J Thorac Dis 5:S479–S490

    Google Scholar 

  • CRUK (2010) Cancer Research UK. Lung cancer incidence statistics in the United Kingdom. http://www.cancerresearchuk.org/cancer-info/cancerstats/types/lung/incidence/-source1. ­Accessed 1 Dec 2013

  • Dobashi Y, Suzuki S, Kimura M, Matsubara H, Tsubochi H, Imoto I, Ooi A (2011) Paradigm of kinase-driven pathway downstream of epidermal growth factor receptor/Akt in human lung carcinomas. Hum Pathol 42:214–226

    Article  PubMed  CAS  Google Scholar 

  • Doll R, Hill AB (1950) Smoking and carcinoma of the lung; preliminary report. Br Med J 2:739–748

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Dong Z, Liu LH, Han B, Pincheira R, Zhang JT (2004) Role of eIF3 p170 in controlling synthesis of ribonucleotide reductase M2 and cell growth. Oncogene 23:3790–3801

    Article  PubMed  CAS  Google Scholar 

  • Fan S, Ramalingam SS, Kauh J, Xu Z, Khuri FR, Sun SY (2009) Phosphorylated eukaryotic translation initiation factor 4 (eIF4E) is elevated in human cancer tissues. Cancer Biol Ther 8:1463–1469

    Article  PubMed  PubMed Central  Google Scholar 

  • Fan S, Li Y, Yue P, Khuri FR, Sun SY (2010) The eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP down-regulation and DR5 induction independent of inhibition of cap-dependent protein translation. Neoplasia 12:346–356

    PubMed  CAS  PubMed Central  Google Scholar 

  • Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM (2008) GLOBOCAN 2008 v2.0, cancer incidence and mortality worldwide: IARC CancerBase No. 10 [Internet]. International Agency for Research on Cancer, Lyon. http://globocan.iarc.fr. Accessed 13 Nov 2013

  • Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer J Int Cancer 127:2893–2917

    Article  CAS  Google Scholar 

  • Gandhi L, Bahleda R, Tolaney SM, Kwak EL, Cleary JM, Pandya SS, Hollebecque A, Abbas R, Ananthakrishnan R, Berkenblit A et al (2014) Phase I study of neratinib in combination with temsirolimus in patients with human epidermal growth factor receptor 2-dependent and other solid tumors. J Clin Oncol 32:68–75

    Article  PubMed  CAS  Google Scholar 

  • Gao W, Shen H, Liu L, Xu J, Xu J, Shu Y (2011) MiR-21 overexpression in human primary squamous cell lung carcinoma is associated with poor patient prognosis. J Cancer Res Clin Oncol 137:557–566

    Article  PubMed  CAS  Google Scholar 

  • Goke R, Barth P, Schmidt A, Samans B, Lankat-Buttgereit B (2004) Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1). Am J Physiol Cell Physiol 287:C1541–1546

    Article  PubMed  CAS  Google Scholar 

  • Grosso S, Pesce E, Brina D, Beugnet A, Loreni F, Biffo S (2011) Sensitivity of global translation to mTOR inhibition in REN cells depends on the equilibrium between eIF4E and 4E-BP1. PLoS ONE 6:e29136

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Han S, Khuri FR, Roman J (2006) Fibronectin stimulates non-small cell lung carcinoma cell growth through activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways. Cancer Res 66:315–323

    Article  PubMed  CAS  Google Scholar 

  • Hartman ML, Esposito JM, Yeap BY, Sugarbaker DJ (2010) Combined treatment with cisplatin and sirolimus to enhance cell death in human mesothelioma. J Thorac Cardiovasc Surg 139:1233–1240

    Article  PubMed  CAS  Google Scholar 

  • He Y, Correa AM, Raso MG, Hofstetter WL, Fang B, Behrens C, Roth JA, Zhou Y, Yu L, Wistuba II et al (2011) The role of PKR/eIF2alpha signaling pathway in prognosis of non-small cell lung cancer. PLoS ONE 6:e24855

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Hoda MA, Mohamed A, Ghanim B, Filipits M, Hegedus B, Tamura M, Berta J, Kubista B, Dome B, Grusch M et al (2011) Temsirolimus inhibits malignant pleural mesothelioma growth in vitro and in vivo: synergism with chemotherapy. J Thorac Oncol 6:852–863

    Article  PubMed  Google Scholar 

  • Holt SV, Logie A, Davies BR, Alferez D, Runswick S, Fenton S, Chresta CM, Gu Y, Zhang J, Wu YL et al (2012) Enhanced apoptosis and tumor growth suppression elicited by combination of MEK (selumetinib) and mTOR kinase inhibitors (AZD8055). Cancer Res 72:1804–1813

    Article  PubMed  CAS  Google Scholar 

  • Hong JY, Chung HJ, Lee HJ, Park HJ, Lee SK (2011) Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa. J Nat Prod 74:2102–2108

    Article  PubMed  CAS  Google Scholar 

  • Hung JY, Hsu YL, Li CT, Ko YC, Ni WC, Huang MS, Kuo PL (2009) 6-Shogaol, an active constituent of dietary ginger, induces autophagy by inhibiting the AKT/mTOR pathway in human non-small cell lung cancer A549 cells. J Agric Food Chem 57:9809–9816

    Article  PubMed  CAS  Google Scholar 

  • Hwang SK, Jin H, Kwon JT, Chang SH, Kim TH, Cho CS, Lee KH, Young MR, Colburn NH, Beck GR, Jr et al (2007) Aerosol-delivered programmed cell death 4 enhanced apoptosis, controlled cell cycle and suppressed AP-1 activity in the lungs of AP-1 luciferase reporter mice. Gene Ther 14:1353–1361

    Article  PubMed  CAS  Google Scholar 

  • Hwang SK, Minai-Tehrani A, Lim HT, Shin JY, An GH, Lee KH, Park KR, Kim YS, Beck GR Jr, Yang, HS et al (2010) Decreased level of PDCD4 (programmed cell death 4) protein activated cell proliferation in the lung of A/J mouse. J Aerosol Med Pulm Drug Deliv 23:285–293

    Article  PubMed  CAS  Google Scholar 

  • Iida M, Brand TM, Campbell DA, Starr MM, Luthar N, Traynor AM, Wheeler DL (2013) Targeting AKT with the allosteric AKT inhibitor MK-2206 in non-small cell lung cancer cells with acquired resistance to cetuximab. Cancer Biol Ther 14:481–491

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Imai H, Kaira K, Oriuchi N, Shimizu K, Tominaga H, Yanagitani N, Sunaga N, Ishizuka T, ­Nagamori S Promchan K et al (2010) Inhibition of L-type amino acid transporter 1 has antitumor activity in non-small cell lung cancer. AnticancerRes 30:4819–4828

    CAS  Google Scholar 

  • Ishikawa D, Takeuchi S, Nakagawa T, Sano T, Nakade J, Nanjo S, Yamada T, Ebi H, Zhao L, Yasumoto K et al (2013) mTOR inhibitors control the growth of EGFR mutant lung cancer even after acquiring resistance by HGF. PLoS ONE 8:e62104

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Jacobson BA, Alter MD, Kratzke MG, Frizelle SP, Zhang Y, Peterson MS, Avdulov S, Mohorn RP, Whitson BA, Bitterman PB et al (2006) Repression of cap-dependent translation attenuates the transformed phenotype in non-small cell lung cancer both in vitro and in vivo. Cancer Res 66:4256–4262

    Article  PubMed  CAS  Google Scholar 

  • Jacobson BA, Thumma SC, Jay-Dixon J, Patel MR, Dubear Kroening K, Kratzke MG, Etchison RG, Konicek BW, Graff JR, Kratzke RA (2013) Targeting eukaryotic translation in mesothelioma cells with an eIF4E-specific antisense oligonucleotide. PLoS ONE 8:e81669

    Article  PubMed  PubMed Central  Google Scholar 

  • Jin H, Kim TH, Hwang SK, Chang SH, Kim HW, Anderson HK, Lee HW, Lee KH, Colburn NH, Yang HS et al (2006) Aerosol delivery of urocanic acid-modified chitosan/programmed cell death 4 complex regulated apoptosis, cell cycle, and angiogenesis in lungs of K-ras null mice. Mol Cancer Ther 5:1041–1049

    Article  PubMed  CAS  Google Scholar 

  • Jorgensen E, Stinson A, Shan L, Yang J, Gietl D, Albino AP (2008) Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells. BMC Cancer 8:229

    Article  PubMed  PubMed Central  Google Scholar 

  • Kalinichenko SV, Kopantzev EP, Korobko EV, Palgova IV, Zavalishina LE, Bateva MV, Petrov AN, Frank GA, Sverdlov ED, Korobko IV (2008) Pdcd4 protein and mRNA level alterations do not correlate in human lung tumors. Lung Cancer 62:173–180

    Article  PubMed  Google Scholar 

  • Kenche H, Baty CJ, Vedagiri K, Shapiro SD, Blumental-Perry A (2013) Cigarette smoking affects oxidative protein folding in endoplasmic reticulum by modifying protein disulfide isomerase. FASEB J 27:965–977

    Article  PubMed  CAS  Google Scholar 

  • Khan N, Afaq F, Khusro FH, Mustafa Adhami V, Suh Y, Mukhtar H (2012) Dual inhibition of phosphatidylinositol 3-kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin. Int J Cancer 130:1695–1705

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Khoury T, Alrawi S, Ramnath N, Li Q, Grimm M, Black J, Tan D (2009) Eukaryotic initiation factor-4E and cyclin D1 expression associated with patient survival in lung cancer. Clin Lung Cancer 10:58–66

    Article  PubMed  CAS  Google Scholar 

  • Kim YY, Von Weymarn L, Larsson O, Fan D, Underwood JM, Peterson MS, Hecht SS, Polunovsky VA, Bitterman PB (2009) Eukaryotic initiation factor 4E binding protein family of proteins: sentinels at a translational control checkpoint in lung tumor defense. Cancer Res 69:8455–8462

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Lai JH, She TF, Juang YM, Tsay YG, Huang AH, Yu SL, Chen JJ, Lai CC (2012) Comparative proteomic profiling of human lung adenocarcinoma cells (CL 1–0) expressing miR-372. Electrophoresis 33, 675–688

    Article  PubMed  CAS  Google Scholar 

  • Li Y, Yue P, Deng X, Ueda T, Fukunaga R, Khuri FR, Sun SY (2010) Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E. Neoplasia 12:848–855

    PubMed  CAS  PubMed Central  Google Scholar 

  • Li Y, Fan S, Koo J, Yue P, Chen ZG, Owonikoko TK, Ramalingam SS, Khuri FR, Sun SY (2012) Elevated expression of eukaryotic translation initiation factor 4E is associated with proliferation, invasion and acquired resistance to erlotinib in lung cancer. Cancer Biol Ther 13:272–280

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Li S, Jia Y, Jacobson B, McCauley J, Kratzke R, Bitterman PB, and Wagner CR (2013) Treatment of breast and lung cancer cells with a N-7 benzyl guanosine monophosphate tryptamine phosphoramidate pronucleotide (4Ei-1) results in chemosensitization to gemcitabine and induced eIF4E proteasomal degradation. Mol Pharm 10:523–531

    Article  PubMed  CAS  Google Scholar 

  • Liang Y, Liu M, Wang P, Ding X, Cao Y (2013) Analysis of 20 genes at chromosome band 12q13: RACGAP1 and MCRS1 overexpression in nonsmall-cell lung cancer. Genes Chromosomes Cancer 52:305–315

    Article  PubMed  CAS  Google Scholar 

  • Liu Z, Wang L, Zhang LN, Wang Y, Yue WT, Li Q (2012) Expression and clinical significance of mTOR in surgically resected non-small cell lung cancer tissues: a case control study. Asian Pac J Cancer Prev 13:6139–6144

    Article  PubMed  Google Scholar 

  • Lwin Z, Riess JW, Gandara D (2013) The continuing role of chemotherapy for advanced non-small cell lung cancer in the targeted therapy era. J Thorac Dis 5:S556–S564

    Google Scholar 

  • Marchetti A, Buttitta F, Pellegrini S, Bertacca G, Callahan R (2001) Reduced expression of INT-6/eIF3-p48 in human tumors. Int J Oncol 18:175–179

    PubMed  CAS  Google Scholar 

  • Nana-Sinkam SP, Powell CA (2013) Molecular biology of lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 143:e30S–39S

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Nyfeler B, Chen Y, Li X, Pinzon-Ortiz M, Wang Z, Reddy A, Pradhan E, Das R, Lehar J, Schlegel R et al (2012) RAD001 enhances the potency of BEZ235 to inhibit mTOR signaling and tumor growth. PLoS ONE 7:e48548

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Pandiri AR, Sills RC, Ziglioli V, Ton TV, Hong HH, Lahousse SA, Gerrish KE, Auerbach SS, Shockley KR, Bushel PR et al (2012) Differential transcriptomic analysis of spontaneous lung tumors in B6C3F1 mice: comparison to human non-small cell lung cancer. Toxicol Pathol 40:1141–1159

    Article  PubMed  Google Scholar 

  • Park SH, Park HS, Lee JH, Chi GY, Kim GY, Moon SK, Chang YC, Hyun, JW, Kim, WJ, Choi YH (2013) Induction of endoplasmic reticulum stress-mediated apoptosis and non-canonical autophagy by luteolin in NCI-H460 lung carcinoma cells. Food Chem Toxicol 56:100–109

    Article  PubMed  CAS  Google Scholar 

  • Pataer A, Vorburger SA, Barber GN, Chada S, Mhashilkar AM, Zou-Yang H, Stewart AL, Balachandran S, Roth JA, Hunt KK et al (2002) Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR). Cancer Res 62:2239–2243

    PubMed  CAS  Google Scholar 

  • Patel MR, Sadiq AA, Jay-Dixon J, Jirakulaporn T, Jacobson BA, Farassati F, Bitterman PB, Kratzke, RA (2012) Novel role of c-jun N-terminal kinase in regulating the initiation of cap-dependent translation. Int J Oncol 40:577–582

    PubMed  CAS  Google Scholar 

  • Patel MR, Jay-Dixon J, Sadiq AA, Jacobson BA, Kratzke RA (2013) Resistance to EGFR-TKI can be mediated through multiple signaling pathways converging upon cap-dependent translation in EGFR-wild type NSCLC. J Thorac Oncol 8:1142–1147

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Pincheira R, Chen Q, Zhang JT (2001) Identification of a 170-kDa protein over-expressed in lung cancers. Br J Cancer 84:1520–1527

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Powell CA, Halmos B, Nana-Sinkam SP (2013) Update in lung cancer and mesothelioma 2012. Am J Respir Crit Care Med 188:157–166

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Price KA, Azzoli CG, Krug LM, Pietanza MC, Rizvi NA, Pao W, Kris MG, Riely GJ, Heelan RT, Arcila ME et al (2010) Phase II trial of gefitinib and everolimus in advanced non-small cell lung cancer. J Thorac Oncol 5:1623–1629

    Article  PubMed  PubMed Central  Google Scholar 

  • Ramalingam SS, Owonikoko TK, Behera M, Subramanian J, Saba NF, Kono SA, Gal AA, Sica G, Harvey RD, Chen Z et al (2013) Phase II study of docetaxel in combination with everolimus for second- or third-line therapy of advanced non-small-cell lung cancer. J Thorac Oncol 8:369–372

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Ren H, Chen M, Yue P, Tao H, Owonikoko TK, Ramalingam SS, Khuri FR, Sun SY (2012) The combination of RAD001 and NVP-BKM120 synergistically inhibits the growth of lung cancer in vitro and in vivo. Cancer Lett 325:139–146

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Rosenwald IB, Hutzler MJ, Wang S, Savas L, Fraire AE (2001) Expression of eukaryotic translation initiation factors 4E and 2alpha is increased frequently in bronchioloalveolar but not in squamous cell carcinomas of the lung. Cancer 92:2164–2171

    Article  PubMed  CAS  Google Scholar 

  • Rothbart SB, Racanelli AC, Moran RG (2010) Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas. Cancer Res 70:10299–10309

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Savas P, Hughes B, Solomon B (2013) Targeted therapy in lung cancer: IPASS and beyond, keeping abreast of the explosion of targeted therapies for lung cancer. J Thorac Dis 5:S579–S592

    Google Scholar 

  • Seki N, Takasu T, Mandai K, Nakata M, Saeki H, Heike Y, Takata I, Segawa Y, Hanafusa T, Eguchi K (2002) Expression of eukaryotic initiation factor 4E in atypical adenomatous hyperplasia and adenocarcinoma of the human peripheral lung. Clin Cancer Res 8:3046–3053

    PubMed  CAS  Google Scholar 

  • Seki N, Takasu T, Sawada S, Nakata M, Nishimura R, Segawa Y, Shibakuki R, Hanafusa T, Eguchi K (2010) Prognostic significance of expression of eukaryotic initiation factor 4E and 4E binding protein 1 in patients with pathological stage I invasive lung adenocarcinoma. Lung Cancer 70:329–334

    Article  PubMed  Google Scholar 

  • Shapiro GI, Rodon J, Bedell C, Kwak EL, Baselga J, Brana I, Pandya SS, Scheffold C, Laird AD, Nguyen LT et al (2013) Phase I safety, pharmacokinetic and pharmacodynamic study of SAR245408 (XL147), a novel oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors. Clin Cancer Res 20(1):233–245

    Article  PubMed  Google Scholar 

  • Shen YH, Chen BR, Cherng SH, Chueh PJ, Tan X, Lin YW, Lin JC, Chuang SM (2011) Cisplatin transiently up-regulates hHR23 expression through enhanced translational efficiency in A549 adenocarcinoma cells. Toxicol Lett 205:341–350

    Article  PubMed  CAS  Google Scholar 

  • Storozhuk Y, Hopmans SN, Sanli T, Barron C, Tsiani E, Cutz JC, Pond G, Wright J, Singh G, ­Tsakiridis T (2013) Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK. Br J Cancer 108:2021–2032

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Sun SY, Rosenberg LM, Wang X, Zhou Z, Yue P, Fu H, Khuri FR (2005) Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res 65:7052–7058

    Article  PubMed  CAS  Google Scholar 

  • Telang S, Nelson KK, Siow DL, Yalcin A, Thornburg JM, Imbert-Fernandez Y, Klarer AC, Farghaly H, Clem BF, Eaton JW et al (2012) Cytochrome c oxidase is activated by the oncoprotein Ras and is required for A549 lung adenocarcinoma growth. Mol Cancer 11:60

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Tilleray V, Constantinou C, Clemens MJ (2006) Regulation of protein synthesis by inducible wild-type p53 in human lung carcinoma cells. FEBS Lett 580:1766–1770

    Article  PubMed  CAS  Google Scholar 

  • Travis WD, Brambilla E, Riely GJ (2013) New pathologic classification of lung cancer: relevance for clinical practice and clinical trials. J Clin Oncol 31:992–1001

    Article  PubMed  CAS  Google Scholar 

  • Trigka EA, Levidou G, Saetta AA, Chatziandreou I, Tomos P, Thalassinos N, Anastasiou N, ­Spartalis E, Kavantzas N, Patsouris E et al (2013) A detailed immunohistochemical analysis of the PI3K/AKT/mTOR pathway in lung cancer: correlation with PIK3CA, AKT1, K-RAS or PTEN mutational status and clinicopathological features. Oncol Rep 30:623–636

    PubMed  CAS  Google Scholar 

  • Varghese S, Chen Z, Bartlett DL, Pingpank JF, Libutti SK, Steinberg SM, Wunderlich J, Alexander HR Jr (2011) Activation of the phosphoinositide-3-kinase and mammalian target of rapamycin signaling pathways are associated with shortened survival in patients with malignant peritoneal mesothelioma. Cancer 117:361–371

    Article  PubMed  CAS  Google Scholar 

  • Villaruz LC, Burns TF, Ramfidis VS, Socinski MA (2013) Personalizing therapy in advanced non-small cell lung cancer. Semin Respir Crit Care Med 34:822–836

    Article  PubMed  Google Scholar 

  • Viola G, Bortolozzi R, Hamel E, Moro S, Brun P, Castagliuolo I, Ferlin MG, Basso G (2012) MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells. Biochem Pharmacol 83:16–26

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Walsh D, Meleady P, Power B, Morley SJ, Clynes M (2003) Increased levels of the translation initiation factor eIF4E in differentiating epithelial lung tumor cell lines. Differentiation 71:126–134

    Article  PubMed  CAS  Google Scholar 

  • Wang R, Geng J, Wang JH, Chu XY, Geng HC, Chen LB (2009) Overexpression of eukaryotic initiation factor 4E (eIF4E) and its clinical significance in lung adenocarcinoma. Lung Cancer 66:237–244

    Article  PubMed  Google Scholar 

  • Wang M, Wang Y, Zang W, Wang H, Chu H, Li P, Li M, Zhang G, Zhao G (2014) Downregulation of microRNA-182 inhibits cell growth and invasion by targeting programmed cell death 4 in human lung adenocarcinoma cells. Tumour Biol 35(1):39–46

    Article  PubMed  Google Scholar 

  • Xu X, Han L, Duan L, Zhao Y, Yang H, Zhou B, Ma R, Yuan R, Zhou H, Liu Z (2013a) Association between eIF3alpha polymorphism and severe toxicity caused by platinum-based chemotherapy in non-small cell lung cancer patients. Br J Clin Pharmacol 75:516–523

    Article  CAS  Google Scholar 

  • Xu X, Han L, Yang H, Duan L, Zhou B, Zhao Y, Qu J, Ma R, Zhou H, Liu Z (2013b) The A/G allele of eIF3a rs3740556 predicts platinum-based chemotherapy resistance in lung cancer patients. Lung Cancer 79:65–72

    Article  Google Scholar 

  • Yang SX, Hewitt SM, Steinberg SM, Liewehr DJ, Swain SM (2007) Expression levels of eIF4E, VEGF, and cyclin D1, and correlation of eIF4E with VEGF and cyclin D1 in multi-tumor tissue microarray. Oncol Rep 17:281–287

    PubMed  CAS  Google Scholar 

  • Yin JY, Shen J, Dong ZZ, Huang Q, Zhong MZ, Feng DY, Zhou HH, Zhang JT, Liu ZQ (2011) Effect of eIF3a on response of lung cancer patients to platinum-based chemotherapy by regulating DNA repair. Clin Cancer Res 17:4600–4609

    Article  PubMed  CAS  Google Scholar 

  • Yoshizawa A, Fukuoka J, Shimizu S, Shilo K, Franks TJ, Hewitt SM, Fujii T, Cordon-Cardo C, Jen J, Travis WD (2010) Overexpression of phospho-eIF4E is associated with survival through AKT pathway in non-small cell lung cancer. Clin Cancer Res 16:240–248

    Article  PubMed  CAS  Google Scholar 

  • Yuan J, Mehta PP, Yin MJ, Sun S, Zou A, Chen J, Rafidi K, Feng Z, Nickel J, Engebretsen J et al (2011) PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity. Mol Cancer Ther 10:2189–2199

    Article  PubMed  CAS  Google Scholar 

  • Zhou W, Quah ST, Verma CS, Liu Y, Lane DP, Brown CJ (2012) Improved eIF4E binding peptides by phage display guided design: plasticity of interacting surfaces yield collective effects. PLoS ONE 7:e47235

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Zhu W, Shen J, Li Q, Pei Q, Chen J, Chen Z, Liu Z, Hu G (2013) Synthesis, pharmacophores and mechanism study of pyridin-2(1H)-one derivatives as regulators of translation initiation factor 3A. Arch Pharm 346:654–666

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of General Surgery, Department of Surgery, Faculty of Medicine, McGill University, Montreal, QC, Canada

    Armen Parsyan

  2. Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA, USA

    Karen L. Reckamp

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  1. Armen Parsyan
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  2. Karen L. Reckamp
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Correspondence to Armen Parsyan .

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  1. Surgery, McGill University, Montreal, Québec, Canada

    Armen Parsyan

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Parsyan, A., Reckamp, K. (2014). Cancers of the Respiratory System. In: Parsyan, A. (eds) Translation and Its Regulation in Cancer Biology and Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9078-9_27

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