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Modelling and Analysis of Feedback Control Mechanisms Underlying Osmoregulation in Yeast

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A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems

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Abstract

Biological systems display complex dynamics emerging from intricate networks of interacting molecular components: cells use signalling pathways and regulatory control mechanisms to coordinate multiple processes, allowing them to respond and adapt to an ever-changing environment. Many structural and dynamical features of biological control systems can also be found in engineered control systems and, hence, feedback control theory can provide a useful approach for the analysis and design of complex biological systems. In this chapter we provide a control theoretic analysis of the osmoregulation system in Saccharomyces cerevisiae (see [8, 24, 26, 40]), where a complex biochemical signalling and regulatory network allows cells to maintain homeostasis in the face of osmotic shock.

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Author information

Authors and Affiliations

  1. Department of Information Engineering, University of Padova, Via Gradenigo 6/b, 35131, Padova, Italy

    Francesco Montefusco

  2. Centre for Systems, Dynamics and Control, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, EX4 4QF, UK

    Ozgur E. Akman

  3. School of Life Sciences, University of Warwick, Gibbet Hill Campus, Coventry, CV4 7AL, UK

    Orkun S. Soyer

  4. School of Engineering, University of Warwick, Coventry, CV4 7AL, UK

    Declan G. Bates

Authors
  1. Francesco Montefusco
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  2. Ozgur E. Akman
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  3. Orkun S. Soyer
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  4. Declan G. Bates
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Corresponding author

Correspondence to Francesco Montefusco .

Editor information

Editors and Affiliations

  1. Electrical and Computer Engineering, University of Minnesota, Minneapolis, Minnesota, USA

    Vishwesh V. Kulkarni

  2. Bioengineering, Imperial College, London, United Kingdom

    Guy-Bart Stan

  3. Biotechnology, Indian Institute of Technology Madras, Chennai, India

    Karthik Raman

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Montefusco, F., Akman, O.E., Soyer, O.S., Bates, D.G. (2014). Modelling and Analysis of Feedback Control Mechanisms Underlying Osmoregulation in Yeast. In: Kulkarni, V., Stan, GB., Raman, K. (eds) A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9047-5_4

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