Skip to main content

Biosynthesis of Cobalamins Including Vitamin B12

  • Chapter
  • First Online:
Book cover Microbial Biochemistry

Abstract

Vitamin B12 can be formally classified with the tetrapyrrole derivatives. It is based on a skeleton called corrin (Fig. 38.1), which differs from the other tetrapyrroles in the absence of a methene bridge between two of the pyrrole rings. In numbering the atoms in this formula, number 20 has been deliberately omitted, in order that all the corrin atoms should correspond to those of the other tetrapyrrole compounds. Some of the biosynthetic intermediates occurring before the formation of hydrogenobyrinic acid are called precorrins.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Selected References

Many references to previous work will be found in the last two chapter.

Threonine Kinase and the Origin of the Aminopropanol Residue

Origin of the Dimethylbenzimidazole

Anaerobic Synthesis of the Corrin Component of Adenosylcobalamin

  • Moore SJ, Lawrence AD, Biedendieck R, Deery E, Frank S, Howard MJ, Rigby SEJ, Warren MJ (2013) Proc Natl Acad Sci USA 110:14906–14911

    Google Scholar 

Anaerobic Pathway for the Corrin Component of Cobalamin

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media B.V.

About this chapter

Cite this chapter

Cohen, G.N. (2014). Biosynthesis of Cobalamins Including Vitamin B12. In: Microbial Biochemistry. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8908-0_38

Download citation

Publish with us

Policies and ethics