Abstract
During the late 1930s, Barker isolated an anaerobic bacterium which he called Clostridium kluyveri. This organism is able to grow on a mixture of acetate and ethanol and produces n-butyrate and n-caproate. From this organism, Barker and Stadtman obtained cell-free extracts which could carry the reactions leading to the C4 and C6 acids. Ethanol is oxidized to acetic acid in two steps, respectively, catalyzed by alcohol dehydrogenase and an acetaldehyde dehydrogenase depending on the presence of coenzyme A:
Keywords
- Fatty Acid Synthesis
- Acyl Carrier Protein
- Fatty Acid Synthetase
- Cyclopropane Fatty Acid
- Biotin Carboxylase
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsSelected References
Short Chain Fatty Acid Synthesis
Barker HA (1956) Bacterial fermentations, Ciba lectures in microbial biochemistry. John Wiley, New York, 95pp
Fatty Acid Synthesis and Its Regulation
Demmer U, Warkentin E, Srivastava A, Kockelkorn D, Potter M, Marx A, Fuchs G, Ermler U (2013) J Biol Chem 288:6363–6370
Schweitzer E (1980) In Bisswanger H, Schmincke-Ott E (eds) Multifunctional proteins. John Wiley, New York, pp 197–215
Singh N, Wakil SJ, Stoops JK (1985) Biochemistry 24:6598–6602
Wakil SJ, Stoops JK, Joshi VC (1983) Annu Rev Biochem 52:537–579
Trimethylamine Production
Craciun S, Balskus EP (2012) Proc Natl Acad Sci USA109:21307–21312
Cyclopropane Fatty Acid Synthetase
Chang YY, Eichel J, Cronan JE Jr (2000) J Bacteriol 182:4288–4294
Eichel J, Chang YY, Riesenberg D, Cronan JE Jr (1999) J Bacteriol 181:572–576
Wang AY, Grogan DW, Cronan JE Jr (1992) Biochemistry 31:11020–11028
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer Science+Business Media B.V.
About this chapter
Cite this chapter
Cohen, G.N. (2014). Biosynthesis of Lipids. In: Microbial Biochemistry. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8908-0_10
Download citation
DOI: https://doi.org/10.1007/978-94-017-8908-0_10
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-017-8907-3
Online ISBN: 978-94-017-8908-0
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)