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Odorant-Receptor Interaction

  • Xubo Su
  • Hiroaki Matsunami
  • Hanyi ZhuangEmail author
Chapter

Abstract

Odorant-receptor interactions constitute a key step in the olfactory detection of chemical compounds. Various studies support the combinatorial coding of olfaction, in which each odorant activates an array of odorant receptors and each odorant receptor is capable of recognizing multiple odorants, while large-scale studies involving numerous odorants and odorant receptors help to resolve the tuning specificities of receptor repertoires. In the meantime, the proteinaceous content of the nasal mucus, including odorant binding proteins and different types of xenobiotic-metabolizing enzymes, also contributes to odorant receptor activation by transporting, concentrating, converting, and/or ultimately removing odorants from nasal mucosa. In addition, the presence of metal ions, notably copper ions, is known to be important for the activation of odorant receptors for certain types of metal-coordinating odorants. Finally, prediction algorithms based on odorant properties and receptor structures are becoming increasingly feasible for investigating detailed mechanisms involved in odorant-receptor interactions.

Keywords

Olfactory Bulb Odorant Receptor Olfactory Sensory Neuron Isovaleric Acid Combinatorial Code 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

We are indebted to Dr. Tai Hyun Park for the invitation to contribute to the book. Our work described here is supported by grants from National Institutes of Health (to H.M.), Chinese National Natural Science Foundation, the National Basic Research Program of China’s 973 Program, Shanghai Municipal Education Commission, Shanghai Education Development Foundation, the Science and Technology Commission of Shanghai (all to H.Z.), and Shanghai Jiaotong University School of Medicine (to X.S.).

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  1. 1.Department of PathophysiologyShanghai Jiaotong University School of MedicineShanghaiP. R. China
  2. 2.Department of Molecular Genetics and MicrobiologyDuke University Medical CenterDurhamUSA
  3. 3.Department of NeurobiologyDuke University Medical CenterDurhamUSA
  4. 4.Institute of Health SciencesShanghai Jiaotong University School of Medicine/Shanghai Institutes for Biological Sciences of Chinese Academy of SciencesShanghaiP. R. China

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