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Burn Shock

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Chinese Burn Surgery

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Abstract

Shock is the first critical step during the cure of patients with severe burns owing to the exosmosis of plasma fractions and the destruction of blood cells within 48 h after the injury, which tends to result in hypovolemic shock. The burn shock has a considerable effect on the whole course, although it occurs at an early stage. Over the last 20 years, the incidence and mortality of shock were directly due to the shock decreasing with as the level of resuscitation during the shock phase increases [1]; however, it does not mean that problems regarding shock have been resolved because the complications affecting the internal organs caused by shock are still tough to treat [2]. It is especially apparent in some grass-roots units that the vague recognition with regard to treatment during the shock phase is still to be clarified. In summary, the necessary content to be defined includes the patterns and compositions of transfusion and the combined treatment in addition to fluid infusion during the shock phase.

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References

  1. Xia ZF, He F, Barrow RE, et al. Reperfusion injury in burned rats after delayed fluid resuscitation. J Burn Care Rehabil. 1991;12(5):430–6.

    Article  CAS  PubMed  Google Scholar 

  2. Wang GY, Xia ZF. Effects of delayed resuscitation of major burns on phospholipase A2 activity. J Fed Am Soc Exp Biol. 1999;13(5):A1096.

    Google Scholar 

  3. Xia ZF, Tang HT, Shen HX. Intracellular calcium abnormality and its mechanism in myocardial cells during the burn shock stage. Prog Nat Sci. 1999;12:1103–9.

    Google Scholar 

  4. Tan JT, Zhao Y, Li W. Clinical effect of rapid fluid replacement on the delayed resuscitation of patients with severe burn shock. West China Med J. 2006;21(2):233–4.

    Google Scholar 

  5. Yan BG, Yang ZC, Huang YS. Effects of rapid fluid replacement on organ damage of burn shock patients. China J Mod Med. 2001;11(5):8–10.

    Google Scholar 

  6. Xia ZF, Hollyoak MA, Barrow RE, et al. Superoxide dismutase and leupeptin prevent delayed reperfusion injury in the rat small intestine during burn shock. J Burn Care Rehabil. 1995;16(2 Pt 1):111–7.

    Article  CAS  PubMed  Google Scholar 

  7. Yu BJ, Liu ZG, Xia ZF, et al. Effects of dantrium and nimodipine on heart function of rabbits after severely burns. J Med Postgrad. 2003;16(10):746–7.

    Google Scholar 

  8. Wang GY, Xia ZF, Zhu SH, et al. Observation on pro-inflammatory cytokine inhibition induced by nimodipine in burned rats. Chin J Burns. 2002;18(5):311–2.

    Google Scholar 

  9. Wang GY, Tang HT, Ma B, et al. Effects of nimodipine on cell protection in the early post-burn stage. Chin J Burn. 2007;23(2):138–9.

    Google Scholar 

  10. Tang B, Zhu JY, Zhu B, et al. Protective effects of Xuebijing injection on organ functions in patients with severe burn. Chin J Integr Tradis West Med Intensive Crit Care. 2007;14(1):14–6.

    Google Scholar 

  11. Shen HX, Fang Y, Chen YL, et al. Effects of post-burn serum on free cytosolic calcium in isolated cardiac myocytes of adult rats. J Med Coll PLA. 1998;13(1):58–62.

    CAS  Google Scholar 

  12. Chen XW, Huang J. Protective effect of low-dose continued application of dopamine on renal function in the early post-burn stage. Chin J Crit Care Med. 2003;23(3):183.

    Google Scholar 

  13. Chen XL, Xia ZF, Wei D, et al. Role of p38 mitogen-activated protein kinase signal transduction pathway in the acute lung injury of severely burned rats. Chin J Surg. 2004;42(7):388–90.

    PubMed  Google Scholar 

  14. Xia ZF. Post-burn multiple organ damage and its management and prevention. Chin J Burn. 2006;22(3):164–7.

    CAS  Google Scholar 

  15. Peng X, Chen RC, Wang P, et al. Effects of enteral supplementation with glutamine on mitochondria respiratory function of intestinal epithelium in burned rats. Chin Crit Care Med. 2004;16(2):93–6.

    CAS  Google Scholar 

  16. Dong YL, Huang KF, Xia ZF. Impact of exogenous insulin-like growth factor-I on hepatic energy metabolism in burn injury. Arch Surg. 1993;128(6):703–8.

    Article  CAS  PubMed  Google Scholar 

  17. Xia ZF, Horton JW, Zhao PY, et al. In vivo studies of cellular energy state, pH and sodium in rat liver after thermal injury. J Appl Physiol. 1994;76(4):1507–11.

    CAS  PubMed  Google Scholar 

  18. Xia ZF, Yu BJ. Decreased nitric oxide production but increased tissue water content in heart, liver and kidney of rats with delayed fluid resuscitation of severe burn. Shock. 1999;11(Suppl l):205.

    Google Scholar 

  19. Xia ZF, Wang GY, Ge SD, et al. Alpha-1 antitrypsin and alpha-1 glycoprotein reduce the sensitivity of human dermal fibroblast to endotoxin. Chin J Traumatol. 2001;4(4):199–204.

    CAS  PubMed  Google Scholar 

  20. Xia ZF, Tian JG, Wang GY, et al. Effect of burn injury on relative anaplerosis and gluconeogenesis in rats by 13C magnetic resonance spectrum. Chin J Traumatol. 2002;5(2):71–6.

    CAS  PubMed  Google Scholar 

  21. Tai HT, Xia ZF, Liu SK, et al. The experience in treatment of patients with extensive full thickness burns. Burns. 1999;25:757–9.

    Article  Google Scholar 

  22. Xia ZF, Tai HT, Horton JW. Correlation between the changes in cardiac contractile function and myocardial cytosolic free calcium level after burn trauma: NMR study. J Burn Care Rehabil. 2002;22(2):S99.

    Google Scholar 

  23. Xia ZF, Wang GY, Zhu SH. Long term effects of recombinant human epithelial growth factor to deep partial thickness burn. J Burn Care Rehabil. 2004;25(2):65.

    Google Scholar 

  24. Sun YH, Yu DN, Chen X, et al. Preliminary study on the improvement of wound microcirculation and retrospection on several methods of the management of deep partial thickness burn wound. Chin J Burn. 2005;21(1):17–20.

    Google Scholar 

  25. Xia ZF. Emphasis on cell protection at the early post-burn stage. Chin J Burn. 2002;18(5):263–5.

    Google Scholar 

  26. Xia ZF, Fang ZY. Relationship between traumatic or hemorrhagic shock and cellular energy metabolism disorder. Chin J Surg. 1987;25(3):495.

    CAS  PubMed  Google Scholar 

  27. Yu BJ, Wang GY, Chen YL, et al. The effect of postburn serum on free intracellular calcium concentration and production of nitric oxide in macrophages. Acad J Second Mil Med Univ. 1998;19(Suppl):49–51.

    Google Scholar 

  28. Lu W, Chen YL, Xia ZF. Modified evens blue fluorimetry for determination of pulmonary vascular permeability in rats sustaining burns, and delayed fluid resuscitation of burn shock. Burns. 1997;23(6):490–2.

    Article  CAS  PubMed  Google Scholar 

  29. Xia ZF, Tian JG, Tang HT, et al. A study on the myocardial contractile function and intracellular free calcium in scalded rats. Chin J Burns. 2001;17(6):342–5.

    CAS  Google Scholar 

  30. Yang Z, Xu W, Shi J. Burns therapy. 2nd ed. [M].Shanghai, China: Shanghai Scientific & Technical Publishers; 1989. p. 56–62.

    Google Scholar 

  31. Xia ZF, Fang ZY, Zhao PY, et al. 31P NMR studies on intracellular pH and energy metabolism of heart, kidney and liver in burn shock. An animal experiment. J Med Coll PLA. 1988;3(4):322–8.

    CAS  Google Scholar 

  32. Hume DM, Egdahl RH.The importance of the brain in the endocrine response to injury. Ann Surg. 1959;150:697–712.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  33. Li YY, Xia ZF, Fang ZY, et al. Endothelin-1 increases capillary permeability after burn trauma. Shock. 1995;3(Suppl):28.

    Google Scholar 

  34. Xia ZF, Shi SJ, Malloy CR, et al. Effects of endothelin on isolated perfused working rat hearts. Acad J Second Mil Med Univ. 1998;19(Suppl):34–6.

    CAS  Google Scholar 

  35. Chen XL, Xia ZF, Wei D, et al. Activation of p38 MAPK signal transduction pathway by burn serum and the expression of VCAM-1 in HUVECs induced by NF-κB. Chin J Burn. 2005;21(6):426–30.

    Google Scholar 

  36. Xia ZF, Wang GY, Tian JG, et al. Effects of endothelin on isolated perfused working rat hearts. J Fed Am Soc Exp Biol. 2004;18(5):A1302.

    Google Scholar 

  37. Xia ZF, He F, Barrow RE, et al. Efficacy of leupeptin, superoxide dismutase, and verapamil in modulating delayed reperfusion damage after burn injury. J Burn Care Rehabil. 1992;13(5):530–7.

    Article  CAS  PubMed  Google Scholar 

  38. Chen XL, Xia ZF. Clinical study on the changes in plasma sodium level and blood erythrocyte after resuscitation with different fluid regimes at early post-burn stage. Chin J Burn. 2004;20(5):284–7.

    CAS  Google Scholar 

  39. Wang GY, Xia ZF, Yu BJ, et al. The clinical significance of SIRS scoring system in severely burned patients. Ann Burn Fire Disaster. 1999;12(4):200–2.

    Google Scholar 

  40. Wang GQ, Xia ZF, Chen YL, et al. The relationship between systemic inflammatory response syndrome and organ dysfunction in severely burned patients: clinical significance of systemic inflammatory response syndrome score. Chin Crit Care Med. 1999;12(11):725–7.

    Google Scholar 

  41. Wang GY, Xia ZF, Yu BJ, et al. Cardiac apoptosis in burned rats with delayed resuscitation. URNs. 2001;27(3):250–4.

    CAS  Google Scholar 

  42. Xia ZF, He F, Herndon DN, et al. The effect of burn injury on the acute phase response. J Trauma. 1992;32(2):245–51.

    Article  CAS  PubMed  Google Scholar 

  43. Xia ZF, Li YY, Chen YL, et al. Induction of hepatic acute phase reactants by conditioned medium from lipopolysaccharide treated human dermal fibroblasts. Acad J Second Mil Med Univ. 1997;18(1):24–7.

    Google Scholar 

  44. Xia ZF, Malloy CR, Zhao PY, et al. Effect of ischemia on intracellular sodium and phosphate in the in vivo rat liver. J Appl Physiol. 1996;81(3):1395–403.

    CAS  PubMed  Google Scholar 

  45. Chen XL, Xia ZF, Wei D, et al. The modulating role of p38 mitogen-activated protein kinase in the expression of tumor necrosis factor-α in hepatic cells and its role in hepatic injury in severely burned rats. Chin J Burn. 2005;21(6):418–22.

    CAS  Google Scholar 

  46. Xia ZF, Shen HX, Chen YL, et al. Alterations of anabolism in hepatic cells of burned rats measured by ~(13)C NMR spectroscopy. Chin J Burn. 2000;16(4):210–4.

    CAS  Google Scholar 

  47. Xia ZF, Zhao PY, Horton JW. NMR relaxation studies on hepatic intra-and extracellular sodium in rats with burn injury. J Burn Care Rehabil. 1997;18(3):193–9.

    Article  CAS  PubMed  Google Scholar 

  48. Xia ZF, Wang GY, Tang HT, et al. Study on the intra and extra-hepatocyte distribution of sodium ions in scalded rats during early post-burn stage. Chin J Burn. 2002;18(5):276–8.

    CAS  Google Scholar 

  49. Xia ZF, Tian JG, Xiong J, et al. Study on the changes in the distribution and chemical states of the hepatic intra-and extra-cellular sodium ion in the rats with severe burns at early stage. Chin J Burn. 2005;21(5):326–9.

    CAS  Google Scholar 

  50. Ge SD. Review and prospect of burn shock in China. Chin J Burn. 2000;16(5):261–4.

    Google Scholar 

  51. Xia ZF. Exploration of the shock mystery. Sci Illus. 1989;2:10–6.

    Google Scholar 

  52. Xia ZF, Fang ZY, Ge SD, et al. 31P NMR studies on intracellular pH and energy metabolism of cardiomyocytes on burned rats. Chin J Plast Surg Burn. 1987;3(2):145–9.

    CAS  Google Scholar 

  53. Tang HT, Chen YL, Yan XM, et al. Early cardiac myocyte membrane changes in severely burned rats: a spin labeling ESR study. Chin J Plast Surg Burn. 1999;15(3):224-7.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Burn Institute, The First Hospital Affiliated to Chinese PLA General Hospital, Beijing, People’s Republic of China

    Zhenrong Guo (Professor)

  2. Burn Institute, Changhai Hospital, Second Military Medical University, Shanghai, People’s Republic of China

    Zhaofan Xia (Professor)

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  1. Zhenrong Guo
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  2. Zhaofan Xia
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Editors and Affiliations

  1. Third Military Medical University, Chongqing, Chong Qing, China

    Zongcheng Yang

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© 2015 Springer Science+Business Media Dordrecht and People's Medical Publishing House

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Guo, Z., Xia, Z. (2015). Burn Shock. In: Yang, Z. (eds) Chinese Burn Surgery. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8575-4_3

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  • DOI: https://doi.org/10.1007/978-94-017-8575-4_3

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  • Print ISBN: 978-94-017-8574-7

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