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Stem Cells and Cancer Stem Cells, Volume 12 pp 47–62Cite as

Induced Pluripotent Stem Cells Differentiate into Functional Cardiomyocytes

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Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 12))

Abstract

The conversion of somatic cells into so called induced pluripotent stem cells (iPSCs) is generally considered as major breakthrough in stem cell research, and cardiomyocytes derived from human iPS cells are considered as promising cell source for disease modelling, drug screening and safety pharmacology, and future therapeutic applications.

This review gives an overview on the molecular basis of cardiac development, recent progress in directing differentiation of pluripotent stem cells into the cardiac lineage and characterisation of the resulting myocytes. Moreover, generation of cardiac cells from disease-specific iPSCs and application of iPSC-derived myocytes for engineering of functional heart tissue and heart repair is discussed.

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Authors and Affiliations

  1. Department of Cardiothoracic, Transplantation and Vascular Surgery, Leibniz Research Laboratories for Biotechnology and Artificial Organs, REBIRTH – Center for Regenerative Medicine (OE 6217), Hannover Medical School, Carl-Neuberg-Str. 1, HBZ – building J11, H0, 30625, Hannover, Germany

    Ruth Olmer & Ulrich Martin

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  1. Ruth Olmer
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  2. Ulrich Martin
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  1. Department of Biological Sciences, Kean University, Room 213, Library Building, Union, New Jersey, USA

    M.A. Hayat

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Olmer, R., Martin, U. (2014). Induced Pluripotent Stem Cells Differentiate into Functional Cardiomyocytes. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 12. Stem Cells and Cancer Stem Cells, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8032-2_5

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