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Repairing the Stroke-Damaged Brain: From Neural Stem Cells to Tissue Engineering

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Stem Cells and Cancer Stem Cells, Volume 12

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 12))

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Abstract

Stroke remains the main cause of adult disability with only very limited treatment options. Cell therapy is gradually emerging from the bench to the bedside, but the specific conditions under which administered cells can be effective remain to be defined. This translation needs to be seen in the context of endogenous repair processes which to some extent involve endogenous neural stem cells which reside in the sub-ependymal zone bordering the lateral ventricles and the sub-granular zone of the hippocampus, as well as local changes involving astrocytes, microglia and endothelial cells. The integration of cells with biomaterials also opens the opportunity for considering a replacement of lost tissue that leaves a cavity in the infarct area. Together, these approaches present new perspectives to repair some damage caused by stroke and eventually to improve outcome of patients for a better quality of life.

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Authors and Affiliations

  1. McGowan Institute for Regenerative Medicine and Centre for the Neural Basis of Cognition, Departments of Radiology and Bioengineering, University of Pittsburgh, 3025 East Carson St., Pittsburgh, PA, 15203, USA

    Michel Modo & Andre Massensini

Authors
  1. Michel Modo
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  2. Andre Massensini
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Correspondence to Michel Modo .

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Editors and Affiliations

  1. Department of Biological Sciences, Kean University, Room 213, Library Building, Union, New Jersey, USA

    M.A. Hayat

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Modo, M., Massensini, A. (2014). Repairing the Stroke-Damaged Brain: From Neural Stem Cells to Tissue Engineering. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 12. Stem Cells and Cancer Stem Cells, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8032-2_16

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