Skip to main content
SpringerLink
Log in

Interventional Treatment of Liver Metastasis of Colorectal Cancer

  • Chapter
  • First Online:
Multidisciplinary Management of Liver Metastases in Colorectal Cancer

  • 922 Accesses

Abstract

The transcatheter arterial infusion (TAI) and transcatheter arterial embolization (TAE) have good effects on a variety of solid tumors. In the treatment of liver cancer, they are more effective, especially. Currently, TAI and TAE not only are main methods in the treatment of unresectable colorectal cancer liver metastases but also play important roles in the adjuvant treatment and new adjuvant therapy of colorectal cancer liver metastases [1–4].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Kelly RJ, Kemeny NE, Leonard GD. Current strategies using hepatic arterial infusion chemotherapy for the treatment of colorectal cancer. Clin Colorectal Cancer. 2005;5(3):166–74.

    Article  PubMed  Google Scholar 

  2. Pasetto LM, Merenda R, Pilati P, et al. Hepatic metastases of colorectal cancer: locoregional intra-arterial treatment. Anticancer Res. 2006;26(6C):4785–92.

    CAS  PubMed  Google Scholar 

  3. Dizon DS, Schwartz J, Kemeny N. Chemotherapy: a focus on hepatic artery infusion for colorectal cancer liver metastases. Surg Oncol Clin N Am. 2008;17(4):759–71.

    Article  PubMed  Google Scholar 

  4. Tsutsumi S, Yamaguchi S, Tsuboi K, et al. Hepatic arterial infusion combined with oral UFT/UZEL systemic chemotherapy for unresectable liver metastasis of colorectal cancer. Hepatogastroenterology. 2008;55(85):1419–22.

    CAS  PubMed  Google Scholar 

  5. Meta-Analysis Group in Cancer. Reappraisal of hepatic arterial infusion in the treatment of nonresectable liver metastases from colorectal cancer. J Natl Cancer Inst. 1996;88(5):252–8.

    Article  Google Scholar 

  6. Harmantas A, Rotstein LE, Langer B. Regional versus systemic chemotherapy in the treatment of colorectal carcinoma metastatic to the liver. Is there a survival difference? Meta-analysis of the published literature. Cancer. 1996;78(8):1639–45.

    Article  CAS  PubMed  Google Scholar 

  7. Kemeny NE, Niedzwiecki D, Hollis DR, et al. Hepatic arterial infusion versus systemic therapy for hepatic metastases from colorectal cancer: a randomized trial of efficacy, quality of life, and molecular markers (CALGB 9481). J Clin Oncol. 2006;24(9):1395–403.

    Article  CAS  PubMed  Google Scholar 

  8. Dzodic R, Gomez-Abuin G, Rougier P, et al. Pharmacokinetic advantage of intra-arterial hepatic oxaliplatin administration: comparative results with cisplatin using a rabbit VX2 tumor model. Anticancer Drugs. 2004;15(6):647–50.

    Article  CAS  PubMed  Google Scholar 

  9. van Riel JM, van Groeningen CJ, Kedde MA, et al. Continuous administration of irinotecan by hepatic arterial infusion: a phase I and pharmacokinetic study. Clin Cancer Res. 2002;8(2):405–12.

    PubMed  Google Scholar 

  10. Falcone A, Ricci S, Brunetti I, et al. Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest. J Clin Oncol. 2007;25(13):1670–6.

    Article  CAS  PubMed  Google Scholar 

  11. Kemeny MM, Adak S, Gray B, Macdonald JS, et al. Combined-modality treatment for resectable metastatic colorectal carcinoma to the liver: surgical resection of hepatic metastases in combination with continuous infusion of chemotherapy – an intergroup study. J Clin Oncol. 2002;20(6):1499–505.

    Article  PubMed  Google Scholar 

  12. Kemeny N, Huang Y, Cohen AM, et al. Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer. N Engl J Med. 1999;341(27):2039–48.

    Article  CAS  PubMed  Google Scholar 

  13. Ychou M, Viret F, Kramar A, et al. Tritherapy with fluorouracil/leucovorin, irinotecan and oxaliplatin (FOLFIRINOX): a phase II study in colorectal cancer patients with non-resectable liver metastases. Cancer Chemother Pharmacol. 2008;62(2):195–201.

    Article  CAS  PubMed  Google Scholar 

  14. Zelek L, Bugat R, Cherqui D, et al. Multimodal therapy with intravenous biweekly leucovorin, 5-fluorouracil and irinotecan combined with hepatic arterial infusion pirarubicin in non-resectable hepatic metastases from colorectal cancer (a European Association for Research in Oncology trial). Ann Oncol. 2003;14(10):1537–42.

    Article  CAS  PubMed  Google Scholar 

  15. Van Cutsem E, Köhne CH, Hitre E, et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med. 2009;360(14):1408–17.

    Article  PubMed  Google Scholar 

  16. Kabbinavar FF, Hurwitz HI, Yi J, et al. Addition of bevacizumab to fluorouracil-based first-line treatment of metastatic colorectal cancer: pooled analysis of cohorts of older patients from two randomized clinical trials. J Clin Oncol. 2009;27(2):199–205.

    Article  CAS  PubMed  Google Scholar 

  17. Ricke J, Hildebrandt B, Miersch A, et al. Hepatic arterial port systems for treatment of liver metastases: factors affecting patency and adverse events. J Vasc Interv Radiol. 2004;15(8):825–33.

    Article  PubMed  Google Scholar 

  18. Iguchi T, Inaba Y, Arai Y, et al. Radiologic removal and replacement of port-catheter systems for hepatic arterial infusion chemotherapy. AJR Am J Roentgenol. 2006;187(6):1579–84.

    Article  PubMed  Google Scholar 

  19. Tono T, Ukei T, Masutani S. Management of hepatic arterial infusion port following prophylactic regional chemotherapy in patients who have undergone curative resection of colorectal liver metastases. Surg Today. 2003;33(9):679–83.

    Article  PubMed  Google Scholar 

  20. Sameshima S, Horikoshi H, Motegi K, et al. Outcomes of hepatic artery infusion therapy for hepatic metastases from colorectal carcinoma after radiological placement of infusion catheters. Eur J Surg Oncol. 2007;33(6):741–5.

    Article  CAS  PubMed  Google Scholar 

  21. Zanon C, Grosso M, Clara R, et al. Percutaneous implantation of arterial Port-a-cath via trans-subclavian access. Anticancer Res. 1999;19:5667–71.

    CAS  PubMed  Google Scholar 

  22. Herrmann KA, Waggershauser T, Sittek H, et al. Liver intraarterial chemotherapy: use of the femoral artery for percutaneous implantation of catheter-port systems. Radiology. 2000;215:294–9.

    Article  CAS  PubMed  Google Scholar 

  23. Yamagami T, Terayama K, Yoshimatsu R, et al. Use of N-butyl cyanoacrylate in implantation of a port-catheter system for hepatic arterial infusion chemotherapy with the fixed-catheter-tip method: is it necessary? AJR Am J Roentgenol. 2008;191(5):1523–9.

    Article  PubMed  Google Scholar 

  24. Hamada A, Yamakado K, Nakatsuka A, et al. Repeated hepatic arterial infusion chemotherapy using an implanted port system in patients with unresectable malignant liver neoplasms: significant factors affecting early hepatic arterial occlusion. Oncol Rep. 2003;10(6):1821–7.

    PubMed  Google Scholar 

  25. Wood BJ, Ramkaransingh JR, Fojo T, et al. Percutaneous tumor ablation with radiofrequency. Cancer. 2002;94(2):443–51.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Nahum Goldberg S, Dupuy DE. Image-guided radiofrequency tumor ablation: challenges and opportunities—part I. J Vasc Interv Radiol. 2001;12(9):1021–32.

    Article  CAS  PubMed  Google Scholar 

  27. Rachbauer F, Mangat J, Bodner G, et al. Heat distribution and heat transport in bone during radiofrequency catheter ablation. Arch Orthop Trauma Surg. 2003;123(2–3):86–90.

    CAS  PubMed  Google Scholar 

  28. Dupuy DE, Goldberg SN. Image-guided radiofrequency tumor ablation: challenges and opportunities—part II. J Vasc Interv Radiol. 2001;12(10):1135–48.

    Article  CAS  PubMed  Google Scholar 

  29. Lau WY, Leung TW, Yu SC, et al. Percutaneous local ablative therapy for hepatocellular carcinoma: a review and look into the future. Ann Surg. 2003;237(2):171–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  30. Allgaier HP, Galandi D, Zuber I, et al. Radiofrequency thermal ablation of hepatocellular carcinoma. Dig Dis. 2001;19(4):301–10.

    Article  CAS  PubMed  Google Scholar 

  31. Rossi S, Buscarini E, Garbagnati F, et al. Percutaneous treatment of small hepatic tumors by an expandable RF needle electrode. AJR Am J Roentgenol. 1998;170(4):1015–22.

    Article  CAS  PubMed  Google Scholar 

  32. Haemmerich D, Wright AW, Mahvi DM, et al. Hepatic bipolar radiofrequency ablation creates coagulation zones close to blood vessels: a finite element study. Med Biol Eng Comput. 2003;41(3):317–23.

    Article  CAS  PubMed  Google Scholar 

  33. Baere TD, Denys A, Wood BJ, et al. Radiofrequency liver ablation: experimental comparative study of water-cooled versus expandable systems. AJR Am J Roentgenol. 2001;176(1):187–92.

    Article  PubMed  Google Scholar 

  34. Kettenbach J, Kostler W, Rucklinger E, et al. Percutaneous saline-enhanced radiofrequency ablation of unresectable hepatic tumors: initial experience in 26 patients. AJR Am J Roentgenol. 2003;180(6):1537–45.

    Article  PubMed  Google Scholar 

  35. Livraghi T, Solbiati L, Meloni MF, et al. Treatment of focal liver tumors with percutaneous radio-frequency ablation: complications encountered in a multicenter study. Radiology. 2003;226(2):441–51.

    Article  PubMed  Google Scholar 

  36. McGrane S, McSweeeney SE, Maher MM. Which patients will benefit from percutaneous radiofrequency ablation of colorectal cancer metastases ? A critically appraised topic. Abdom Imaging. 2008;33:48–53.

    Article  PubMed  Google Scholar 

  37. Solbiati L, Livrhagi T, Goldberg SN, et al. Percutaneous radiofrequency ablation of hepatic metastases from colorectal cancer: long-term results in 117 patients. Radiology. 2001;221:159–66.

    Article  CAS  PubMed  Google Scholar 

  38. Siperstein A, Berber E, Ballerm N, Rikesh T. Survival after radiofrequency ablation of colorectal metastases: 10-year-experience. Ann Surg. 2007;246:559–67.

    Article  PubMed  Google Scholar 

  39. Veltri A, Sacchetto P, Tosetti I, et al. Radiofrequency ablation of colorectal liver metastases: small size favorably predicts technique effectiveness and survival. Cardiovasc Intervent Radiol. 2008;31:948–56.

    Article  PubMed  Google Scholar 

  40. Ruers T, van Coevorden F, Pierie JPJ, et al. Radiofrequency ablation (RFA) combined with chemotherapy for unresectable colorectal liver metastases (CRC LM): interim results of a randomized phase II study of the EORTC-NCRI CCSG-ALM Intergroup 40004 (CLOCC). J Clin Oncol. 2008, ASCO annual meeting proceedings; 2008, 26:4012.

    Google Scholar 

  41. Livraghi T, Solbiati L, Meloni F, et al. Percutaneous radiofrequency ablation of liver metastases in potential candidates for resection: the “test-of-time approach”. Cancer. 2003;97:3027–35.

    Article  PubMed  Google Scholar 

  42. Kokudo N, Miki Y, Sugai S, et al. Genetic and histological assessment of surgical margins in resected liver metastases from colorectal carcinoma: minimum surgical margins for successful resection. Arch Surg. 2002;137:833–40.

    Article  PubMed  Google Scholar 

  43. Pawlik TM, Scoggins CR, Zorzi D, et al. Effect of surgical margin status on survival and site of recurrence after hepatic resection for colorectal metastases. Ann Surg. 2005;241:715–22.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Mulier S, Ni Y, Jamart J, et al. Local recurrence after hepatic radiofrequency coagulation: multivariate meta-analysis and review of contributing factors. Ann Surg. 2005;242:158–71.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Oka M, Hazama S, Suzuki M, et al. Depression of cytotoxicity of nonparenchymal cells in the liver after surgery. Surgery. 1994;116:877–82.

    CAS  PubMed  Google Scholar 

  46. Wissniowski TT, Hansler J, Neureiter D, et al. Activation of tumor-specific T lymphocytes by radio-frequency ablation of the VX2 hepatoma in rabbits. Cancer Res. 2003;63:6496–500.

    CAS  PubMed  Google Scholar 

  47. Zerbini A, Pilli M, Penna A, Pelosi G, et al. Radiofrequency thermal ablation of hepatocellular carcinoma liver nodules can activate and enhance tumor-specific T-cell responses. Cancer Res. 2006;66:1139–46.

    Article  CAS  PubMed  Google Scholar 

  48. Oshowo A, Gillams A, Harrison E, et al. Comparison of resection and radiofrequency ablation for treatment of solitary colorectal liver metastases. Br J Surg. 2003;90(10):1240–3.

    Article  CAS  PubMed  Google Scholar 

  49. Abdalla EK, Vauthey JN, Ellis LM, et al. Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases. Ann Surg. 2004;239(6):818–25.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Mulier S, Ni Y, Jamart J, et al. Radiofrequency ablation versus resection for respectable colorectal liver metastases: time for a randomized trial? Ann Surg Oncol. 2008;15:144–57.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Zhongshan Hospital, Fudan University, 180 Fenglin Road, Xuhui District, Shanghai, 200032, China

    Jianhua Wang & Yi Chen

Authors
  1. Jianhua Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yi Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jianhua Wang .

Editor information

Editors and Affiliations

  1. Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

    Xinyu Qin

  2. Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

    Jianmin Xu

  3. Department of General Surgery, Zhongshan Hospital, Shanghai, China

    Yunshi Zhong

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer Science+Business Media Dordrecht and People's Medical Publishing House

About this chapter

Cite this chapter

Wang, J., Chen, Y. (2017). Interventional Treatment of Liver Metastasis of Colorectal Cancer. In: Qin, X., Xu, J., Zhong, Y. (eds) Multidisciplinary Management of Liver Metastases in Colorectal Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-7755-1_18

Download citation

  • DOI: https://doi.org/10.1007/978-94-017-7755-1_18

  • Published:

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-017-7753-7

  • Online ISBN: 978-94-017-7755-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation