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Mas-Related G Protein-Coupled Receptors Offer Potential New Targets for Pain Therapy

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Translational Research in Pain and Itch

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 904))

Abstract

The founding member of the Mas-related G-protein-coupled receptor (Mrgpr) family was discovered in 1986. Since then, many more members of this receptor family have been identified in multiple species, and their physiologic functions have been investigated widely. Because they are expressed exclusively in small-diameter primary sensory neurons, the roles of Mrgpr proteins in pain and itch have been best studied. This review will focus specifically on the current knowledge of their roles in pathological pain and the potential development of new pharmacotherapies targeted at some Mrgprs for the treatment of chronic pain. We will also discuss the limitations and future scope of this receptor family in pain treatment.

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Acknowledgment

The authors thank Claire F. Levine, MS (scientific editor, Department of Anesthesiology/CCM, Johns Hopkins University), for editing the manuscript. The authors declare no competing interests.

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    Authors and Affiliations

    1. Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA

      Vineeta Tiwari, Vinod Tiwari, Shaoqiu He, Tong Zhang, Srinivasa N. Raja, Xinzhong Dong & Yun Guan

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    1. Vineeta Tiwari
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    Correspondence to Yun Guan .

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    1. Dep of Anatomy,Histology and Embryology, Inst of Basic Med Sci Neroscien Cntr, Beijing, China

      Chao Ma

    2. Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, China

      Yuguang Huang

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    © 2016 Springer Science+Business Media Dordrecht

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    Tiwari, V. et al. (2016). Mas-Related G Protein-Coupled Receptors Offer Potential New Targets for Pain Therapy. In: Ma, C., Huang, Y. (eds) Translational Research in Pain and Itch. Advances in Experimental Medicine and Biology, vol 904. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-7537-3_7

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