Abstract
A tumor suppressor gene is a type of cancer gene that is created by a loss-of-function mutation. In contrast to the activating mutations that generate oncogenic alleles from proto-oncogene precursors, tumor suppressor genes and the proteins they encode are functionally inactivated by mutations.
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Mutation of the orthologous gene in Drosophila causes a notched-wing phenotype.
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Bunz, F. (2016). Tumor Suppressor Genes. In: Principles of Cancer Genetics. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-7484-0_3
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DOI: https://doi.org/10.1007/978-94-017-7484-0_3
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