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Oncogenes

  • Fred Bunz
Chapter

Abstract

An oncogene is a mutated form of a normal cellular gene – called a proto-oncogene – that contributes to the development of a cancer. Proto-oncogenes typically regulate basic processes that direct cell growth and cell differentiation. Most proto-oncogenes are highly conserved in evolutionarily diverse species, underscoring the fact that genes of this class play central roles in fundamental cellular processes. Mutations of proto-oncogenes that cause their conversion to oncogenes cause many of the perturbations in cell growth and differentiation that are commonly seen in cancer cells.

Keywords

PIK3CA Mutation Blast Crisis Philadelphia Chromosome MYCN Amplification Single Base Substitution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Further Reading

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Copyright information

© Springer Science+Business Media B.V. 2016

Authors and Affiliations

  • Fred Bunz
    • 1
  1. 1.The Johns Hopkins UniversityBaltimoreUSA

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