Skip to main content

The Transradial Approach for Bifurcation Lesions

  • Chapter
  • First Online:
Book cover Transradial Approach for Percutaneous Interventions
  • 805 Accesses

Abstract

The history of transradial approach for cardiac catheterism begins before the one of transfemoral approach. The technique is adapted in 1992 for PCI by Kiemeneij. Since that time this approach is proved to be superior to femoral approach regarding the risk of vascular complications, more comfortable for the patient, perfectly adapted to outpatient diagnosis and coronary intervention. A reduction of procedural related mortality has been found speciallyin acute coronary syndroms situations. The transradial approach has been adapted to most clinical, angiographical and technical subsets for PCI. Transradial approach for coronary diagnosis and intervention are related to anatomy, like some anatomical variations and small size of the vessel. For the treatment of coronary bifurcation lesions the only one specific limitation is the necessity of 6F guiding catheter (it can be a sheathless one), and for only one technique a 7F (the Simultaneous Kissing Stent). Acornary bifurcation is an anatomic and physiologic entity dedicated to flow flow distribution, with 3 segments, Proximal Main, Distal Main and Side Branch, and 3 different diameter.In non left main bifurcation the provisional side branch stenting strategy is the most frequently used after multiple randomized comparison with techniques begining with side branch stenting (inverted Culotte, DK Crush Transradial approach can be used also to treat distal left main stenosis using the same techniques, without any randomized comparative trial published.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Radner S. Thoracal aortography by catheterization from the radial artery; preliminary report of a new technique. Acta Radiol. 1948;29(2):178–80.

    Article  CAS  PubMed  Google Scholar 

  2. Seldinger SI. Catheter replacement of the needle in percutaneous arteriography; a new technique. Acta Radiol. 1953;39(5):368–76.

    Article  CAS  PubMed  Google Scholar 

  3. Shirey EK, Sones FM. Retrograde transaortic and mitral valve catheterization. Physiologic and morphologic evaluation of aortic and mitral valve lesions. Am J Cardiol. 1966;18(5):745–53.

    Article  CAS  PubMed  Google Scholar 

  4. Ricketts HJ, Abrams HL. Percutaneous selective coronary cine arteriography. JAMA. 1962;181:620–4.

    Article  CAS  PubMed  Google Scholar 

  5. Campeau L. Entry sites for coronary angiography and therapeutic interventions: from the proximal to the distal radial artery. Can J Cardiol. 2001;17(3):319–25. Review.

    CAS  PubMed  Google Scholar 

  6. Campeau L. Percutaneous radial artery approach for coronary angiography. Cathet Cardiovasc Diagn. 1989;16(1):3–7.

    Article  CAS  PubMed  Google Scholar 

  7. Kiemeneij F, Laarman GJ. Percutaneous transradial artery approach for coronary stent implantation. Cathet Cardiovasc Diagn. 1993;30(2):173–8. Erratum in: Cathet Cardiovasc Diagn 1993 Dec;30(4):358.

    Article  CAS  PubMed  Google Scholar 

  8. Kiemeneij F, Laarman GJ. Percutaneous transradial artery approach for coronary Palmaz-Schatz stent implantation. Am Heart J. 1994;128(1):167–74.

    Article  CAS  PubMed  Google Scholar 

  9. Kiemeneij F, Laarman GJ, de Melker E. Transradial artery coronary angioplasty. Am Heart J. 1995;129(1):1–7.

    Article  CAS  PubMed  Google Scholar 

  10. Kiemeneij F, Laarman GJ, Slagboom T, van der Wieken R. Outpatient coronary stent implantation. J Am Coll Cardiol. 1997;29(2):323–7.

    Article  CAS  PubMed  Google Scholar 

  11. Abhaichand RK, Louvard Y, Gobeil JF, Loubeyre C, Lefèvre T, Morice MC. The problem of arteria lusoria in right transradial coronary angiography and angioplasty. Catheter Cardiovasc Interv. 2001;54(2):196–201.

    Article  CAS  PubMed  Google Scholar 

  12. Mann T, Cubeddu G, Bowen J, Schneider JE, Arrowood M, Newman WN, Zellinger MJ, Rose GC. Stenting in acute coronary syndromes: a comparison of radial versus femoral access sites. J Am Coll Cardiol. 1998;32(3):572–6.

    Article  CAS  PubMed  Google Scholar 

  13. Delarche N, Idir M, Estrade G, Leblay M. Direct Angioplasty for Acute Myocardial Infarction in Elderly Patients Using TransradialApproach. Am J Geriatr Cardiol. 1999;8(1):32–3.

    PubMed  Google Scholar 

  14. Louvard Y, Ludwig J, Lefèvre T, Schmeisser A, Brück M, Scheinert D, Loubeyre C, Klinghammer L, Morice MC, Flachskampf FA, Daniel WG. Transradial approach for coronary angioplasty in the setting of acute myocardial infarction: a dual-center registry. Catheter Cardiovasc Interv. 2002;55(2):206–11.

    Article  PubMed  Google Scholar 

  15. Saito S, Tanaka S, Hiroe Y, Miyashita Y, Takahashi S, Tanaka K, Satake S. Comparative study on transradial approach vs. transfemoral approach in primary stent implantation for patients with acute myocardial infarction: results of the test for myocardial infarction by prospective unicenter randomization for access sites (TEMPURA) trial. Catheter Cardiovasc Interv. 2003;59(1):26–33.

    Article  PubMed  Google Scholar 

  16. Hildick-Smith DJ, Walsh JT, Lowe MD, Petch MC. Coronary angiography in the fully anticoagulated patient: the transradial route is successful and safe. Catheter Cardiovasc Interv. 2003;58(1):8–10.

    Article  PubMed  Google Scholar 

  17. Lim PO, Dzavík V. Balloon crush: treatment of bifurcation lesions using the crush stenting technique as adapted for transradial approach of percutaneous coronary intervention. Catheter Cardiovasc Interv. 2004;63(4):412–6.

    Article  PubMed  Google Scholar 

  18. Ziakas A, Klinke P, Mildenberger R, Fretz E, Williams MB, Della Siega A, Kinloch RD, Hilton JD. Comparison of the radial and femoral approaches in left main PCI: a retrospective study. J Invasive Cardiol. 2004;16(3):129–32.

    CAS  PubMed  Google Scholar 

  19. Watt J, Oldroyd KG. Radial versus femoral approach for high-speed rotational atherectomy. Catheter Cardiovasc Interv. 2009;74(4):550–4.

    Article  PubMed  Google Scholar 

  20. Kiemeneij F, Laarman GJ, Odekerken D, Slagboom T, van der Wieken R. A randomized comparison of percutaneous transluminal coronary angioplasty by the radial, brachial and femoral approaches: the access study. J Am Coll Cardiol. 1997;29(6):1269–75.

    Article  CAS  PubMed  Google Scholar 

  21. Morice MC, Dumas P, Lefèvre T, Loubeyre C, Louvard Y, Piéchaud JF. Systematic use of transradial approach or suture of the femoral artery after angioplasty: attempt at achieving zero access site complications. Catheter Cardiovasc Interv. 2000;51(4):417–21.

    Article  CAS  PubMed  Google Scholar 

  22. Kiemeneij F, Hofland J, Laarman GJ, van der Elst DH, van der Lubbe H. Cost comparison between two modes of Palmaz Schatz coronary stent implantation:transradial bare stent technique vs. transfemoral sheath-protected stent technique. Cathet Cardiovasc Diagn. 1995;35(4):301–8.

    Article  CAS  PubMed  Google Scholar 

  23. Cooper CJ, El-Shiekh RA, Cohen DJ, Blaesing L, Burket MW, Basu A, Moore JA. Effect of transradial access on quality of life and cost of cardiac catheterization: A randomized comparison. Am Heart J. 1999;138(3 Pt 1):430–6.

    Article  CAS  PubMed  Google Scholar 

  24. Louvard Y, Lefèvre T, Allain A, Morice M. Coronary angiography through the radial or the femoral approach: The CARAFE study. Catheter Cardiovasc Interv. 2001;52(2):181–7.

    Article  CAS  PubMed  Google Scholar 

  25. Louvard Y, Benamer H, Garot P, Hildick-Smith D, Loubeyre C, Rigattieri S, Monchi M, Lefèvre T, Hamon M, OCTOPLUS Study Group. Comparison of transradial and transfemoral approaches for coronary angiography and angioplasty in octogenarians (the OCTOPLUS study). Am J Cardiol. 2004;94(9):1177–80.

    Article  PubMed  Google Scholar 

  26. Bertrand OF, Arsenault J, Mongrain R. Operator vs patient radiation exposure it transradial and transfemoral coronary interventions. Eur Heart J. 2008;29(20):2577–8.

    Article  PubMed  Google Scholar 

  27. Brueck M, Bandorski D, Kramer W, Wieczorek M, Höltgen R, Tillmanns H. A randomized comparison of transradial versus transfemoral approach for coronary angiography and angioplasty. JACC Cardiovasc Interv. 2009;2(11):1047–54.

    Article  PubMed  Google Scholar 

  28. Behan M, Haworth P, Colley P, Brittain M, Hince A, Clarke M, Ghuran A, Saha M, Hildick-Smith D. Decreasing operators’ radiation exposure during coronary procedures: the transradial radiation protection board. Catheter Cardiovasc Interv. 2010;76(1):79–84.

    Article  PubMed  Google Scholar 

  29. Ratib K, Mamas MA, Fraser DG, Routledge H, Stables R, Nolan J. Operator experience and radiation exposure during transradial and transfemoral procedures. JACC Cardiovasc Interv. 2011;4(8):936–7.

    Article  PubMed  Google Scholar 

  30. Lo TS, Ratib K, Chong AY, Bhatia G, Gunning M, Nolan J. Impact of access site selection and operator expertise on radiation exposure; a controlled prospective study. Am Heart J. 2012;164(4):455–61.

    Article  PubMed  Google Scholar 

  31. Chase AJ, Fretz EB, Warburton WP, Klinke WP, Carere RG, Pi D, Berry B, Hilton JD. Association of the arterial access site at angioplasty with transfusion and mortality: the M.O.R.T.A.L. study (Mortality benefit Of Reduced Transfusion after percutaneous coronary intervention via the Arm or Leg). Heart. 2008;94(8):1019–25.

    Article  CAS  PubMed  Google Scholar 

  32. Jolly SS, Yusuf S, Cairns J, Niemelä K, Xavier D, Widimsky P, Budaj A, Niemelä M, Valentin V, Lewis BS, Avezum A, Steg PG, Rao SV, Gao P, Afzal R, Joyner CD, Chrolavicius S, Mehta SR, RIVAL trial group. Radial versus femoral access for coronary angiography and intervention in patients with acute coronary syndromes (RIVAL): a randomised, parallel group, multicentre trial. Lancet. 2011;377(9775):1409–20.

    Article  PubMed  Google Scholar 

  33. Romagnoli E, Biondi-Zoccai G, Sciahbasi A, et al. Radial versus femoral randomized investigation in ST-segment elevation acute coronary syndrome: the RIFLE-STEACS (Radial Versus Femoral Randomized Investigation in ST-Elevation Acute Coronary Syndrome) study. J Am Coll Cardiol. 2012;60:2481–9.

    Article  PubMed  Google Scholar 

  34. Nicolosi AC, Pohl LL, Parsons P, Cambria RA, Olinger GN. Increased incidence of radial artery calcification in patients with diabetes mellitus. J Surg Res. 2002;102(1):1–5.

    Article  PubMed  Google Scholar 

  35. Lo TS, Nolan J, Fountzopoulos E, Behan M, Butler R, Hetherington SL, Vijayalakshmi K, Rajagopal R, Fraser D, Zaman A, Hildick-Smith D. Radial artery anomaly and its influence on transradial coronary procedural outcome. Heart. 2009;95(5):410–5.

    Article  CAS  PubMed  Google Scholar 

  36. Burzotta F, Brancati MF, Trani C, Tommasino A, Porto I, Niccoli G, Leone AM, Coluccia V, Di Noi P, Crea F. Impact of radial-to-aorta vascular anatomical variants on risk of failure in trans-radialcoronary procedures. Catheter Cardiovasc Interv. 2012;80(2):298–303.

    Article  PubMed  Google Scholar 

  37. Cheaito R, Benamer H, Hovasse T, Tritar A, Hage F, Garot P, Lefèvre T, Unterseeh T, Chevalier B, Morice MC, Louvard Y. Feasibility and safety of transradial coronary interventions using a 6.5-F sheathless guiding catheter in patients with small radial arteries: a multicenter registry. Catheter Cardiovasc Interv. 2015;86(1):51–8. doi:10.1002/ccd.25508.

    Article  PubMed  Google Scholar 

  38. Takahashi S, Saito S, Tanaka S, Miyashita Y, Shiono T, Arai F, Domae H, Satake S, Itoh T. New method to increase a backup support of a 6 French guiding coronary catheter. Catheter Cardiovasc Interv. 2004;63(4):452–6.

    Article  PubMed  Google Scholar 

  39. Kumar S, Gorog DA, Secco GG, Di Mario C, Kukreja N. The GuideLiner “child” catheter for percutaneous coronary intervention–early clinical experience. J Invasive Cardiol. 2010;22(10):495–8.

    PubMed  Google Scholar 

  40. Murray CD. The physiological principle of minimum work. I. The vascular system and the cost of blood volume. Proc Natl Acad Sci U S A. 1926;12:207–14.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Kassab GS. Scaling laws of vascular trees: of form and function. Am J Physiol Heart Circ Physiol. 2005;290:H894–903.

    Article  PubMed  Google Scholar 

  42. Huo Y, Kassab G. A scaling Law of vascular volume. Biophysical J. 2009;96:347–53.

    Article  CAS  Google Scholar 

  43. Finet G, Gilard M, Perrenot B, Rioufol G, Motreff P, Gavit L, Prost R. Fractal geometry of arterial coronary bifurcations: a quantitative coronary angiography and intravascular ultrasound analysis. EuroIntervention. 2008;3(4):490–8.

    Article  PubMed  Google Scholar 

  44. Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Feldman CL, Stone PH. Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior. J Am Coll Cardiol. 2007;49(25):2379–93. Epub 2007 Jun 8. Review.

    Article  CAS  PubMed  Google Scholar 

  45. Nakazawa G, Yazdani SK, Finn AV, Vorpahl M, Kolodgie FD, Virmani R. Pathological findings at bifurcation lesions: the impact of flow distribution on atherosclerosis and arterial healing after stent implantation. J Am Coll Cardiol. 2010;55(16):1679–87.

    Article  PubMed  Google Scholar 

  46. Medina A, Suárez de Lezo J, Pan M. A new classification of coronary bifurcation lesions. Rev Esp Cardiol. 2006;59(2):183.

    Article  PubMed  Google Scholar 

  47. Louvard Y, Thomas M, Dzavik V, Hildick-Smith D, Galassi AR, Pan M, Burzotta F, Zelizko M, Dudek D, Ludman P, Sheiban I, Lassen JF, Darremont O, Kastrati A, Ludwig J, Iakovou I, Brunel P, Lansky A, Meerkin D, Legrand V, Medina A, Lefèvre T. Classification of coronary artery bifurcation lesions and treatments: time for a consensus! Catheter Cardiovasc Interv. 2008;71(2):175–83.

    Article  PubMed  Google Scholar 

  48. Lansky A, Tuinenburg J, Costa M, Maeng M, Koning G, Popma J, Cristea E, Gavit L, Costa R, Rares A, Van Es GA, Lefevre T, Reiber H, Louvard Y, Morice MC. Quantitative angiographic methods for bifurcation lesions: a consensus statement from the European Bifurcation Group. European Bifurcation Angiographic Sub-Committee. Catheter Cardiovasc Interv. 2009;73(2):258–66.

    Article  PubMed  Google Scholar 

  49. Goktekin O, Kaplan S, Dimopoulos K, Barlis P, Tanigawa J, Vatankulu MA, Koning G, Tuinenburg JC, Mario CD. A new quantitative analysis system for the evaluation of coronary bifurcation lesions: comparison with current conventional methods. Catheter Cardiovasc Interv. 2007;69(2):172–80.

    Article  PubMed  Google Scholar 

  50. Ramcharitar S, Onuma Y, Aben JP, Consten C, Weijers B, Morel MA, Serruys PW. A novel dedicated quantitative coronary analysis methodology for bifurcation lesions. EuroIntervention. 2008;3(5):553–7.

    Article  PubMed  Google Scholar 

  51. Ahn JM, Kang SJ, Yoon SH, Park HW, Kang SM, Lee JY, Lee SW, Kim YH, Lee CW, Park SW, Mintz GS, Park SJ. Meta-analysis of outcomes after intravascular ultrasound-guided versus angiography-guided drug-eluting stent implantation in 26,503 patients enrolled in three randomized trials and 14 observational studies. Am J Cardiol. 2014;113(8):1338–47.

    Article  PubMed  Google Scholar 

  52. Di Mario C, Lakovou I, Van der Giessen WJ, Foin N, Adrianssens T, Tyczynski P, Ghilencea L, Viceconte N, Lindsay AC. Optical coherence tomography for guidance in bifurcation lesion treatment. EuroIntervention. 2010;6(Suppl J):J99–106.

    Article  PubMed  Google Scholar 

  53. Zamani P, Kinlay S. Long-term risk of clinical events from stenting side branches of coronary bifurcation lesions with drug-eluting and bare-metal stents: an observational meta-analysis. Catheter Cardiovasc Interv. 2011;77(2):202–12.

    Article  PubMed  Google Scholar 

  54. Katritsis DG, Siontis GC, Ioannidis JP. Double versus single stenting for coronary bifurcation lesions: a meta-analysis. Circ Cardiovasc Interv. 2009;2(5):409–15.

    Article  PubMed  Google Scholar 

  55. Behan MW, Holm NR, Curzen NP, Erglis A, Stables RH, de Belder AJ, Niemelä M, Cooter N, Chew DP, Steigen TK, Oldroyd KG, Jensen JS, Lassen JF, Thuesen L, Hildick-Smith D. Simple or complex stenting for bifurcation coronary lesions: a patient-level pooled-analysis of the Nordic Bifurcation Study and the British Bifurcation Coronary Study. Circ Cardiovasc Interv. 2011;4(1):57–64.

    Article  PubMed  Google Scholar 

  56. Zimarino M, Corazzini A, Ricci F, Di Nicola M, De Caterina R. Late thrombosis after double versus single drug-eluting stent in the treatment of coronary bifurcations: a meta-analysis of randomized and observational Studies. JACC Cardiovasc Interv. 2013;6(7):687–95.

    Article  PubMed  Google Scholar 

  57. Chen SL, Santoso T, Zhang JJ, Ye F, Xu YW, Fu Q, Kan J, Paiboon C, Zhou Y, Ding SQ, Kwan TW. A randomized clinical study comparing double kissing crush with provisional stenting for treatment of coronary bifurcation lesions: results from the DKCRUSH-II (Double Kissing Crush versus Provisional Stenting Technique for Treatment of Coronary Bifurcation Lesions) trial. J Am Coll Cardiol. 2011;57(8):914–20.

    Article  PubMed  Google Scholar 

  58. Gao XF, Zhang YJ, Tian NL, Wu W, Li MH, Bourantas CV, Jiang XM, Wang ZM, Li B, Mao WX, Zhang JJ, Chen SL. Stenting strategy for coronary artery bifurcation with drug eluting stents: a meta-analysis of nine randomised trials and systematic review. EuroIntervention. 2014;10(5):561–9.

    Article  PubMed  Google Scholar 

  59. Lassen JF, Holm NR, Stankovic G, Lefèvre T, Chieffo A, Hildick-Smith D, Pan M, Darremont O, Albiero R, Ferenc M, Louvard Y. Percutaneous coronary intervention for coronary bifurcation disease: consensus from the first 10 years of the European Bifurcation Club meetings. EuroIntervention. 2014;10(5):545–60.

    Article  PubMed  Google Scholar 

  60. Toyofuku M, Kimura T, Morimoto T, Hayashi Y, Shiode N, Okimoto T, Otsuka M, Tamekiyo H, Tamura T, Kadota K, Inoue K, Mitsudo K, j-Cypher Registry investigators. Comparison of target-lesion revascularisation between left main coronary artery bifurcations andleft anterior descending coronary artery bifurcations using the one and two stent approach with sirolimus-eluting stents. EuroIntervention. 2011;7(7):796–804.

    Article  PubMed  Google Scholar 

  61. Palmerini T, Marzocchi A, Tamburino C, Sheiban I, Margheri M, Vecchi G, Sangiorgi G, Santarelli A, Bartorelli A, Briguori C, Vignali L, Di Pede F, Ramondo A, Inglese L, De Carlo M, Falsini G, Benassi A, Palmieri C, Filippone V, Sangiorgi D, Barlocco F, De Servi S. Impact of bifurcation technique on 2-year clinical outcomes in 773 patients with distal unprotected left main coronary artery stenosis treated with drug-eluting stents. Circ Cardiovasc Interv. 2008;1(3):185–92.

    Article  PubMed  Google Scholar 

  62. Koo BK, Kang HJ, Youn TJ, Chae IH, Choi DJ, Kim HS, Sohn DW, Oh BH, Lee MM, Park YB, Choi YS, Tahk SJ. Physiologic assessment of jailed side branch lesions using fractional flow reserve. J Am Coll Cardiol. 2005;46(4):633–7.

    Article  PubMed  Google Scholar 

  63. Nam CW, Hur SH, Koo BK, Doh JH, Cho YK, Park HS, Yoon HJ, Kim H, Chung IS, Kim YN, Fearon WF, Tahk SJ, Kim KB. Fractional flow reserve versus angiography in left circumflex ostial intervention after left main crossover stenting. Korean Circ J. 2011;41(6):304–7.

    Article  PubMed  PubMed Central  Google Scholar 

  64. Mylotte D, Hovasse T, Ziani A, Lefèvre T, Dumonteil N, Louvard Y, Carrie D. Non-compliant balloons for final kissing inflation in coronary bifurcation lesions treated with provisional side branch stenting: a pilot study. EuroIntervention. 2012;7(10):1162–9.

    Article  PubMed  Google Scholar 

  65. Burzotta F, Gwon HC, Hahn JY, Romagnoli E, Choi JH, Trani C, Colombo A. Modified T-stenting with intentional protrusion of the side-branch stent within the main vessel stent to ensure ostial coverage and facilitate final kissing balloon: the T-stenting and small protrusion technique (TAP-stenting). Report of bench testing and first clinical Italian-Korean two-centre experience. Catheter Cardiovasc Interv. 2007;70(1):75–82.

    Article  PubMed  Google Scholar 

  66. Silva JD, Carrillo X, Salvatella N, Fernandez-Nofrerias E, Rodriguez-Leor O, Mauri J, Bayes-Genis A. The utility of stent enhancement to guide percutaneous coronary intervention for bifurcation lesions. EuroIntervention. 2013;9(8):968–74.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yves Louvard .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Louvard, Y., Lefevre, T. (2017). The Transradial Approach for Bifurcation Lesions. In: Zhou, Y., Kiemeneij, F., Saito, S., Liu, W. (eds) Transradial Approach for Percutaneous Interventions. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-7350-8_16

Download citation

  • DOI: https://doi.org/10.1007/978-94-017-7350-8_16

  • Published:

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-017-7349-2

  • Online ISBN: 978-94-017-7350-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics