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Locomotor Recovery After Spinal Cord Transection: Transplantation of Oligodendrocytes and Motoneuron Progenitors from Human Embryonic Stem Cells

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Stem Cells and Cancer Stem Cells, Volume 13

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 13))

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Abstract

During the last few years, human embryonic stem cells have begun to take a place in the stem cell therapy panorama, especially in respect to the nervous system. The extensive experimental research efforts have focused on translating in vitro cellular regeneration to in vivo transplantation and survival of the transplants, in order to improve clinical outcomes. For spinal cord injury recovery, two major types of cells are in focus: the oligodendrocytes and motor neurons. In this chapter, we will discuss the progressive development of the cellular generation protocols and the locomotor outcome of their transplantation at sites on spinal cord injury. The newly advanced method of motor neurons and oligodendrocytes generation form human induced pluripotent stem cells will be also discussed.

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Authors and Affiliations

  1. California Neurosurgical Institute, Thousand Oaks, CA, 91361, USA

    Nimer Adeeb, Aman Deep & Martin M. Mortazavi

  2. Pediatric Neurosurgery, Children’s of Alabama, Birmingham, AL, 35233, USA

    R. Shan Tubbs

Authors
  1. Nimer Adeeb
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  2. R. Shan Tubbs
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  3. Aman Deep
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  4. Martin M. Mortazavi
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Corresponding author

Correspondence to R. Shan Tubbs .

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Editors and Affiliations

  1. Department of Biological Sciences, Kean University, Union, New Jersey, USA

    M.A. Hayat

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Adeeb, N., Tubbs, R.S., Deep, A., Mortazavi, M.M. (2015). Locomotor Recovery After Spinal Cord Transection: Transplantation of Oligodendrocytes and Motoneuron Progenitors from Human Embryonic Stem Cells. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 13. Stem Cells and Cancer Stem Cells, vol 13. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-7233-4_5

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