Effect of Concentration on the Interactions of Gold Nanoparticles with Model Cell Membranes: A QCM-D Study
The increasing applications of nanotechnology in everyday life require consideration of their interactions with living cells. There are different physical and chemical properties affecting the interactions of nanoparticles with cells, such as NP size, nature of functionalization or stabilizing groups, concentration, and the environment in which nanoparticles are interacting with cells. In this review, we summarize some of our previous studies done on the interactions of gold nanoparticles with supported lipid bilayers (SLB; models for cell membranes). These studies have been done via Quartz Crystal Microbalance with Dissipation (QCM-D) and they include NPs ranging in size from 2 to 40 nm at several concentrations. Their interactions with a SLB composed of l-α-phosphatidylcholine were characterized. In order to better understand how NPs behave in the environment, these interactions were also studied in the presence of different types of natural organic matter (NOM), including Aldrich humic acid, Suwannee River humic acid standard, Suwannee River fulvic acid standard, and Elliot soil humic acid. Here we review our previous findings while focusing on an example of the effect of concentration on NP-SLB interaction.
KeywordsHumic Acid Gold Nanoparticles Natural Organic Matter Quartz Crystal Microbalance With Dissipation Suwannee River Fulvic Acid
This work was supported in part by the National Science Foundation (CBET 0966496). For help with concentration experiments, the authors thank Jeniece Macedonio for her contribution.
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