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The Role of Metabolomics in the Study of Cancer Biomarkers and in the Development of Diagnostic Tools

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Advances in Cancer Biomarkers

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 867))

Abstract

This chapter introduces the emerging field of metabolomics and its application in the context of cancer biomarker research. Taking advantage of modern high-throughput technologies, and enhanced computational power, metabolomics has a high potential for cancer biomarker identification and the development of diagnostic tools. This chapter describes current metabolomics technologies used in cancer research, starting with metabolomics sample preparation, elaborating on current analytical methodologies for metabolomics measurement and introducing existing software for data analysis. The last part of this chapter deals with the statistical analysis of very large metabolomics datasets and their relevance for cancer biomarker identification.

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Acknowledgments

The authors thank Dr. Christian Jäger for the critical review of the book chapter.

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Authors and Affiliations

  1. Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 7, avenue des Hauts-Fourneaux, 4362, Esch-sur-Alzette, Luxembourg

    Jean-Pierre Trezzi & Karsten Hiller

  2. Adobe Research, San Jose, CA, (USA)

    Nikos Vlassis

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  1. Jean-Pierre Trezzi
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  2. Nikos Vlassis
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  3. Karsten Hiller
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Correspondence to Karsten Hiller .

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Editors and Affiliations

  1. Institute of Biochemistry and Clinical B, Catholic University School of Medicine, Rome, Italy

    Roberto Scatena

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Trezzi, JP., Vlassis, N., Hiller, K. (2015). The Role of Metabolomics in the Study of Cancer Biomarkers and in the Development of Diagnostic Tools. In: Scatena, R. (eds) Advances in Cancer Biomarkers. Advances in Experimental Medicine and Biology, vol 867. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-7215-0_4

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