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Gastrointestinal Motility in Health and Disease pp 619–624Cite as

Evidence suggesting prostaglandins mediate lower oesophageal sphincter incompetence associated with inflammation

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Abstract

At this meeting 2 years ago we showed that oesophagitis could be created in cats by infusing hydrochloric acid into the animal’s lower oesophagus. This oesophagitis markedly decreased the resting pressure of the lower oesophageal sphincter (normally abbreviated to LES). Furthermore the response of the inflamed LES to various pharmacological stimuli has been described1. This paper reports results of our attempts to prevent the oesophagitis with indomethacin.

Keywords

  • Lower Esophageal Sphincter
  • Gastrointestinal Motility
  • Mucous Gland
  • Lower Esophageal Sphincter Relaxation
  • Lower Oesophageal Sphincter

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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  • DOI: 10.1007/978-94-017-4389-1_68
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References

  1. Higgs, R. H., Castell, D. O. and Eastwood, G. L. (1976). Studies on the mechanism of esophagitis-induced lower esophageal sphincter hypotension in cats. Gastroenterology, 71, 51

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  2. Behar, J., Biancani, P. and Sheahan, D. (1976). Evaluation of esophageal tests in the diagnosis of reflux esophagitis. Gastroenterology, 71, 9

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  3. Mulhopadhyeh, A., Rattan, S. and Goyal, R. (1975). Effect of prostaglandin Ez on esophageal motility in man. J. Appl. Physiol., 39, 479

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  4. Goyal, R. and Rattan, S. P. (1973). Mechanism of the lower esophageal sphincter relaxation. J. Clin. Invest., 52, 337

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  5. Ferreira, S. and Vane, J. (1974). New aspects of the mode of action of non-steroidal anti-inflammatory drugs. Ann. Rev. Pharmaeol., 14, 57

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Authors
  1. F. Brown
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  2. B. Beck
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  3. R. Fletcher
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  4. D. Castell
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  5. G. Eastwood
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Editor information

Editors and Affiliations

  1. The Royal Infirmary, University Surgical Department, Sheffield, UK

    H. L. Duthie (Professor of Surgery) (Professor of Surgery)

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© 1978 Springer Science+Business Media New York

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Brown, F., Beck, B., Fletcher, R., Castell, D., Eastwood, G. (1978). Evidence suggesting prostaglandins mediate lower oesophageal sphincter incompetence associated with inflammation. In: Duthie, H.L. (eds) Gastrointestinal Motility in Health and Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-4389-1_68

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  • DOI: https://doi.org/10.1007/978-94-017-4389-1_68

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-017-4391-4

  • Online ISBN: 978-94-017-4389-1

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