Human lower oesophageal sphincter (LES) response to submaximal and maximal effective doses of synthetic human big gastrin (G-34) and gastrin I (G-17) (Abstract)

Abstract

Gastrin has been proposed as one of the regulators of human lower oesophageal sphincter pressure (LESP). G-17 in pharmacologic doses significantly increases LESP in man. We compared the effects of maximal and submaximal doses of synthetic G-34 and G-17 on LESP in five normal men. Subjects received, on separate days, rapid intravenous injections of 12.5, 25, and 100 pmol/kg of G-34, G-17 or saline. Serum gastrin levels were determined by radioimmunoassay. The mean LESP calculated for the 10 min period before each injection was considered the basal pressure. The mean change in LESP from basal was determined for continuous 2 min intervals after G-34 injection and 1 min intervals after G-17. Results: Maximal LESP increases occurred 2–6 min after G-34 injections and 1–3 min after G-17 injections. Peak responses to equimolar doses of G-34 and G-17 were similar, but the responses to G-34 were more prolonged.