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VIP antagonizes motilin-induced antral contractions in vitro

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Book cover Gastrointestinal Motility in Health and Disease

Abstract

Both vasoactive intestinal peptide (VIP) and motilin are candidate hormones of the gut1. Both are released by acid in the duodenum in man2,3 and dog4,5. Only for motilin were stimulated endogenous serum levels comparable to those seen after motilin infusion resulting in motor effects of the gut6,7. Thus motilin may well become an established gut hormone.

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References

  1. Grossman, M. I. (1974). Candidate hormones of the gut. Gastroenterology, 67, 730

    PubMed  CAS  Google Scholar 

  2. Bloom, S. R., Mitchell, S. J., Greenberg, G. R., Christofides, N., Domschke, W., Domschke, S., Mitznegg, P. and Demling, L. (1977). Release of VIP by duodenal acidification in man. Gut, Abstract (in press)

    Google Scholar 

  3. Mitznegg, P., Bloom, S. R., Domschke, W., Domschke, S., Wunsch, E. and Demling, L. (1976). Release of motilin after duodenal acidification. Lancet, i, 888

    Article  Google Scholar 

  4. Ebeid, A. M., Murray, P. and Fischer, J. E. (1977). Vasoactive intestinal peptide: the fourth physiological gut hormone? Gastroenterology, 72, A32

    Google Scholar 

  5. Brown, J. C. (1977). International Symposium on Gut Hormones. June 18–19, Lausanne, Switzerland, discussion remark

    Google Scholar 

  6. Domschke, W., Lux, G., Mitznegg, P., Rösch, W., Domschke, S., Bloom, S. R., Wünsch, E. and Demling, L. (1976). Relationship of plasma motilin response to lower esophageal sphincter pressure in man. Scand. J. Gastroenterol., 11 (suppl. 39), 81

    CAS  Google Scholar 

  7. Itoh, Z., Honda, R., Hiwatashi, K., Takeuchi, S., Aizawa, I., Takayanagi, R. and Couch, E. F. (1976). Motilin-induced mechanical activity in the canine alimentary tract. Scand. J. Gastroenterol., 11 (suppl. 39), 93

    CAS  Google Scholar 

  8. Bryant, M. G., Bloom, S. R., Polak, J. M., Albuquerque, R. H., Modlin, I. and Pearse, A. G. E. (1976). Possible dual role for VIP-gastrointestinal hormone and neurotransmitter substance. Lancet, i, 991

    Article  Google Scholar 

  9. Burnstock, G. (1972). Purinergic nerves. Pharmacol. Rev., 24, 509

    PubMed  CAS  Google Scholar 

  10. Goyal, R. K. and Rattan, S. (1975). Nature of the vagal inhibitory innervation to the lower esophageal sphincter. J. Clin. Invest., 55, 1119

    Article  PubMed  CAS  Google Scholar 

  11. Anuras, S., Cooke, A. R. and Christensen, J. (1974). An inhibitory innervation at the gastroduodenal junction. J. Clin. Invest., 54, 529

    Article  PubMed  CAS  Google Scholar 

  12. Torgersen, J. (1942). The muscular build and movements of the stomach and duodenal bulb. Acta Radiol., suppl. 45, 82

    Google Scholar 

  13. Dowd, J. E. and Riggs, D. S. (1965). A comparison of estimates of Michaelis—Menten kinetic constants from various linear transformations. J. Biol. Chem., 240, 863

    PubMed  CAS  Google Scholar 

  14. Strunz, U., Domschke, W., Domschke, S., Mitznegg, P., Wünsch, E., Jaeger, E. and Demling, L. (1976). Potentiation between 13-nle-motilin and acetylcholine on rabbit polyric muscle in vitro. Scand. J. Gastroenterol., 11 (suppl. 39), 29

    CAS  Google Scholar 

  15. Ormsbee, H. S. III and Mir, S. S. (1978). The role of the cholinergic nervous system in the gastrointestinal response to motilin in vivo. Chapter 13, this volume

    Google Scholar 

  16. Strunz, U., Domschke, W., Mitznegg, P., Domschke, S., Schubert, E., Wünsch, E., Jaeger, E. and Demling, L. (1975). Analysis of the motor effects of 13-nle-motilin on the rabbit, guinea pig, rat, and human alimentary tract in vitro. Gastroenterology, 68, 1485

    PubMed  CAS  Google Scholar 

  17. Piper, P. J., Said, S. and Vane, J. R. (1970). Effects on smooth muscle preparations of unidentified vasoactive peptides from intestine and lung. Nature, 225, 1144

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. U. Strunz
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  2. P. Mitznegg
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  3. S. Domschke
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  4. W. Domschke
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  5. E. Wunsch
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  6. L. Demling
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Editor information

Editors and Affiliations

  1. The Royal Infirmary, University Surgical Department, Sheffield, UK

    H. L. Duthie (Professor of Surgery) (Professor of Surgery)

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© 1978 Springer Science+Business Media New York

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Strunz, U., Mitznegg, P., Domschke, S., Domschke, W., Wunsch, E., Demling, L. (1978). VIP antagonizes motilin-induced antral contractions in vitro . In: Duthie, H.L. (eds) Gastrointestinal Motility in Health and Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-4389-1_14

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  • DOI: https://doi.org/10.1007/978-94-017-4389-1_14

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-017-4391-4

  • Online ISBN: 978-94-017-4389-1

  • eBook Packages: Springer Book Archive

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