Abstract
Stanley Cohen at Stanford, Herbert Boyer at the University of California in San Francisco, and their co-workers (Cohen et al., 1973) were the first to set into action the theoretical knowledge referring to restriction. With the help of ligase, they fused a piece of foreign DNA, in the form of a restriction fragment, with a small plasmid, cleaved by the same restriction enzyme (Excursus 20-1). Then, they tried transforming E. coli cells using this artificially combined DNA: it worked! The experiment marked the onset of a new era.
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© 2002 Springer Science+Business Media Dordrecht
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Hausmann, R. (2002). Molecular Clones. In: To Grasp the Essence of Life. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-3540-7_20
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DOI: https://doi.org/10.1007/978-94-017-3540-7_20
Publisher Name: Springer, Dordrecht
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