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The protective role of nitric oxide in hepatocytes during responses to inflammatory mediators and induction of apoptosis

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The Hepatocyte Review

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Abstract

The acute phase response (APR) has evolved in multicellular organisms as a result of their ever-changing surroundings. It refers to the alterations in cellular metabolism and genetic expression that have allowed organisms to maintain homeostasis and survive environmental stress. Frequently the APR is a systemic reaction to external stimuli, such as trauma, burn or infection; however it can also result from internal stimuli, such as neoplasia, pregnancy, or immunopathology [1]. The gross changes include: fever, somnolence, anorexia, thrombocytopenia, alterations in the hormonal milieu, and a net-negative nitrogen balance as the result of decreased protein synthesis [2]. Many of these changes are now understood to be the result of signalling cascades that act through inflammatory mediators, on individual cells, to produce organ specific responses.

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  1. Department of Surgery, University of Pittsburgh, Pittsburgh, PA, 15261, USA

    Christopher A. Bombeck, Jianrong Li, Young-Myeong Kim & Timothy R. Billiar

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  1. Christopher A. Bombeck
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Michael N. Berry Anthony M. Edwards

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Bombeck, C.A., Li, J., Kim, YM., Billiar, T.R. (2000). The protective role of nitric oxide in hepatocytes during responses to inflammatory mediators and induction of apoptosis. In: Berry, M.N., Edwards, A.M. (eds) The Hepatocyte Review. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-3345-8_19

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