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Myocardial Damage pp 159–172Cite as

The Assessment of Myocardial Damage in Heart Transplantation

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 205))

Abstract

The central aim of cardiac surgery is to preserve myocardial function during the perioperative period whilst operating on the heart. Different strategies have evolved to protect the heart during an obligatory ischaemic insult which have resulted in safer surgery and acceptable myocardial function in the post-operative period [1]. It is likely that all cardiac operations cause some degree of cardiac injury but until the development of the newer markers of myocardial damage such as troponin-T, troponin-I and CK-MB isoforms, the assessment of injury was difficult to define [2]. With the use of these novel markers the assessment of pre, peri and post-operative injury has been more precise. These new markers of myocardial injury also allow comparisons of different strategies of myocardial protection [3,4]. In the field of cardiac transplantation there is the potential for myocardial damage in the donor organ prior to transplantation (pre-operative), during the “obligatory” ischaemic time between procurement and reperfusion in the recipient (peri-operative) and during the rejection process in the post-operative period. The role of newer markers of myocardial injury has been explored in each of these settings in patients undergoing transplantation at St. George’s Hospital and the results of these studies form the basis of this chapter.

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Authors
  1. Jon R. Anderson
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Editors and Affiliations

  1. St George’s Hospital Medical School, London, UK

    Juan Carlos Kaski MD, MRCP, FACC, FESC (Reader in Clinical Cardiology and Consultant Cardiologist, Head of Coronary Artery Disease Research Group) (Reader in Clinical Cardiology and Consultant Cardiologist, Head of Coronary Artery Disease Research Group)

  2. Department of Cardiological Sciences, St George’s Hospital Medical School, London, UK

    David W. Holt BSc, PhD, FRCPath (Director of Analytical Unit) (Director of Analytical Unit)

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© 1998 Springer Science+Business Media Dordrecht

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Anderson, J.R. (1998). The Assessment of Myocardial Damage in Heart Transplantation. In: Kaski, J.C., Holt, D.W. (eds) Myocardial Damage. Developments in Cardiovascular Medicine, vol 205. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-2380-0_14

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  • DOI: https://doi.org/10.1007/978-94-017-2380-0_14

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-5056-4

  • Online ISBN: 978-94-017-2380-0

  • eBook Packages: Springer Book Archive

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