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Bacteriocins: mechanism of membrane insertion and pore formation

  • Chapter
Lactic Acid Bacteria: Genetics, Metabolism and Applications

Abstract

Lactic acid bacteria produce several types of pore forming peptides. Class I bacteriocins are lantibiotics that contain (methyl)lanthionine residues that may form intramolecular thioether rings. These peptides generally have a broad spectrum of activity and form unstable pores. Class II bacteriocins are small, heat stable peptides mostly with a narrow spectrum of activity. Most bacteriocins interact with anionic lipids that are abundantly present in the membranes of Gram-positive bacteria. ‘Docking molecules’ may enhance the conductivity and stability of lantibiotic pores, while ‘receptors’ in the target membrane may determine specificity of class II bacteriocins. Insertion into the membrane of many bacteriocins is proton motive force driven. Lantibiotics may form pores according to a ‘wedge-like’ model, while class II bacteriocins may enhance membrane permeability either by the formation of a ‘barrel stave’ pore or by a ‘carpet’ mechanism.

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Authors and Affiliations

  1. Department of Microbiology and the Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, 9751 NN, Haren, The Netherlands

    Gert N. Moll, Wil N. Konings & Arnold J. M. Driessen

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  1. Gert N. Moll
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  2. Wil N. Konings
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  3. Arnold J. M. Driessen
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Correspondence to Arnold J. M. Driessen .

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  1. University of Groningen, The Netherlands

    W. N. Konings  & O. P. Kuipers  & 

  2. Utrecht University, The Netherlands

    J. H. J. Huis In ’t Veld

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© 1999 Springer Science+Business Media Dordrecht

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Moll, G.N., Konings, W.N., Driessen, A.J.M. (1999). Bacteriocins: mechanism of membrane insertion and pore formation. In: Konings, W.N., Kuipers, O.P., In ’t Veld, J.H.J.H. (eds) Lactic Acid Bacteria: Genetics, Metabolism and Applications. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-2027-4_8

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  • DOI: https://doi.org/10.1007/978-94-017-2027-4_8

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-5312-1

  • Online ISBN: 978-94-017-2027-4

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