Abstract
The Systolic Hypertension in the Elderly Program (SHEP) was a randomized multicenter double-blind placebo-controlled trial designed to test the efficacy of antihypertensive drug treatment in persons 60 years of age or older who had isolated systolic hypertension (ISH). ISH was defined as a systolic blood pressure (SBP) (160–219 mmHg) and a diastolic blood pressure (DBP) (< 90 mmHg). Prior to the completion of SHEP, ISH remained the most important unresolved therapeutic problem involving hypertension; no definitive data were available on the possible benefits of treating this condition. Previous randomized controlled trials on efficacy of antihypertensive drug treatment, including the few that included older people in their samples, have focused primarily on the problem of elevated DBP (90 mmHg or higher) and used diastolic hypertension as the sole or main entry criterion.
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References
Perry HM, Jr, Smith WM, McDonald RH et al. Morbidity and mortality in the Systolic Hypertension in the Elderly Program (SHEP) Pilot Study. Stroke 1989; 20: 4 - 13.
Joint National Committee. The Fifth report of the Joint National Committee on detection, evaluation, and treatment of high blood pressure. Arch Intern Med. 1993; 153: 154 - 83.
Collins R, Peto R, MacMahon S et al. Blood pressure, stroke and coronary heart disease
II: Short-term reductions in blood pressure; overview of randomized drug trials in their epidemiological context. Lancet 1990; 335: 827 - 38.
SHEP Cooperative Research Group: Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension, Final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA 1991; 265: 24; 3255.
Hulley SB, Furberg CD, Gurland B et al. The Systolic Hypertension in the Elderly Program (SHEP): Antihypertensive efficacy of chlorthalidone, Am J Cardiol 1985; 56: 913.
The SHEP Cooperative Research Group: Prevention of Various Stroke Types by treatment of isolated systolic hypertension. Presented at the Second World Congress of Stroke, International Stroke Society, September 8-12, Washington, DC, 1992.
The SHEP Cooperative Research Group: The prevention of stroke by treatment of isolated systolic hypertension — strokes prevented are not mild. Presented at Second World Congress of Stroke, International Stroke Society, September 8-12, Washington, DC, 1992.
The SHEP Cooperative Research Group: Implications of the Systolic Hypertension in the Elderly Program, Hypertens 1993; 21; 3: 335 - 43.
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© 1994 Springer Science+Business Media Dordrecht
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Perry, H.M. et al. (1994). The systolic hypertension in the elderly program. In: Leonetti, G., Cuspidi, C. (eds) Hypertension in the Elderly. Developments in Cardiovascular Medicine, vol 157. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-1820-2_8
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DOI: https://doi.org/10.1007/978-94-017-1820-2_8
Publisher Name: Springer, Dordrecht
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