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What is the Helicobacter pylori global reinfection rate?

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Helicobactor pylori

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Abstract

Since the initiation of Helicobacter pylori treatment in the 1980s, concerns have been raised that high reinfection rates might mitigate against H. pylori treatment. Reinfection has been of particular concern where primary infection rates are also high, i.e. in developing countries. In Bangladesh and Brazil, where studies have indicated high annual reinfection rates, investigators have expressed pessimism about long-term treatment benefits1,2. Even in developed countries such as the United States, however, the reinfection rate has been a concern. Given that infection with multiple strains is relatively common, the likelihood of reinfection following treatment seems particularly plausible3. If those who are actively infected can be reinfected, what is to prevent such a phenomenon in recently treated patients? Knowing the reinfection rate provides important data on natural acquisition of host immunity, providing insights into vaccine development and other immunological therapies. Moreover, from a pathophysiological standpoint, distinguishing reinfection from recrudescence of unsuccessfully treated infection permits us to better delineate the best antimicrobial strategies.

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Authors
  1. J. Parsonnet
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Editors and Affiliations

  1. Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, L8N 3Z5, Hamilton, Ontario, Canada

    Richard H. Hunt (Professor of Medicine, Director) (Professor of Medicine, Director)

  2. Department of Gastroenterology and Hepatology, Academic Medical Centre, 9 Meibergdreef, 1105 AZ, Amsterdam, The Netherlands

    Guido N. J. Tytgat (Professor) (Professor)

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© 2003 Springer Science+Business Media Dordrecht

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Parsonnet, J. (2003). What is the Helicobacter pylori global reinfection rate?. In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobactor pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-1763-2_35

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  • DOI: https://doi.org/10.1007/978-94-017-1763-2_35

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-5778-5

  • Online ISBN: 978-94-017-1763-2

  • eBook Packages: Springer Book Archive

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