Fundamentals of Cell Immobilisation Biotechnology

Volume 8A of the series Focus on Biotechnology pp 141-161

Microcarriers for Animal Cell Culture

  • Elena MarkvichevaAffiliated withShemyakin&Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
  • , Christian GrandfilsAffiliated withCentre Interfacultaire des Biomatériaux (CEIB), University of Liège

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Due to a great recent progress in animal cell biotechnology in particular in gene engineering, large-scale production of important biological materials, such as viral vaccines, viral vectors, as well as various cell products has become an industrial reality. The list of these products includes recombinant proteins and peptides, lymphokines and cytokines, enzymes, monoclonal antibodies, hormones, growth factors (e.g. platelet-derived growth factor (PDFG), epithelial growth factor (EGF), colony-stimulating factor (CSF), tissue plasminogen activator, serum proteins (e.g. factor VIII, factor IX), tumour necrosis factor (TNF), erythropoietin (EPO), nucleic acids etc. Some of these products are available on the market as human and animal diagnostics and therapeutics. Many others are currently undergoing evaluation in a developmental process or in clinical trials.