Abstract
Low density lipoprotein (LDL) is the major carrier of cholesterol and its esters in human blood plasma. Free radical-peroxidation of LDL may play a crucial role in the development of atherosclerosis, and much effort has been devoted to the study of lipoprotein oxidation and its prevention over the last decade [1, 2]. Peroxidation of the LDL’s lipids affords hydroperoxides principally from cholesteryl linoleate (Ch18:2), the predominant lipid component in the lipoprotein core [3]. Hydroperoxide formation is generally thought to precede and result in the modification of apoprotein B-100, the single protein associated with LDL. Once modified, the apoprotein is taken up by scavenger receptors of monocyte-derived macrophages. Internalization of lipids in this manner is uncontrolled, and leads to intracellular lipid accumulation and the appearance of lipid-laden foam cells similar to those found in early atherosclerotic lesions.
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© 1997 Springer Science+Business Media Dordrecht
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Porter, N.A., Havrilla, C.M., Kenar, J.A. (1997). Mechanisms of Oxidation of Hydrocarbons, Lipids and Low Density Lipoproteins. In: Minisci, F. (eds) Free Radicals in Biology and Environment. NATO ASI Series, vol 27. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-1607-9_9
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DOI: https://doi.org/10.1007/978-94-017-1607-9_9
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