Abstract
Free radicals can be generated either as by-products of normal cellular metabolism or as a result of exposure of cells or tissues to a wide range of external stimuli [1]. Subsequent reactions of the initially produced radicals with cellular components can result in widespread biological damage. Thus it is known that radicals can damage nucleic acids, proteins, carbohydrates and lipids; as a consequence radicals have been implicated in a number of human diseases and pathologies [1].
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Halliwell, B. and Gutteridge, J.M.C. (1989) Free Radicals in Biology and Medicine, Clarendon Press, Oxford.
von Sonntag, C. (1987) The Chemical Basis of Radiation Biology, Taylor and Francis, London.
Chan, H.W.-S. (ed.) (1987) Autoxidation of Unsaturated Lipids, Academic Press, London.
Garrison, W.M. (1987) Reaction mechanisms in the radiolysis of peptides, polypeptides and proteins, Chem. Rev. 87, 381–398.
Stadtman, E.R. (1993) Oxidation of free amino acids and amino acid residues in proteins by radiolysis and by metal-catalysed reactions, Ann. Rev. Biochem.. 62, 797–821.
Wolff, S.P., Gamer, A.W. and Dean, R.T. (1986) Free radicals, lipids and protein breakdown, Trends Biochem. Sci. 11, 27–31.
Dean, R.T., Gieseg, S. and Davies, M.J. (1993) Reactive species and their accumulation on radical-damaged proteins, Trends Biochem. Sci. 18, 437–441.
Davies, KJ.A. (1987) Protein damage and degradation by oxygen radicals I. General aspects, J. Biol. Chem. 262, 9895–9901.
Wayner, D.D.M., Burton, G.W., Ingold; KU., Barclay, L.R.C. and Locke, SJ. (1987) The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma,Biochim. Biophys. Acta 924, 408–419.
Neuzil, J., Gebicki, J.M. and Stocker, R. (1993) Radical-induced chain oxidation of proteins and its inhibition by chain-breaking antioxidants, Biochem. J. 293, 601606.
Simpson, J.A., Narita, S., Gieseg, S., Gebicki, S., Gebicki, J.M. and Dean, R.T. (1992) Long-lived reactive species on free-radical-damaged proteins, Biochem. J. 282, 621–624.
Gebicki, S. and Gebicki, J.M. (1993) Formation of peroxides in amino acids and proteins exposed to oxygen free radicals, Biochem. J. 289, 743–749.
Gieseg, S. P., Simpson, J.A., Charlton, T.S., Duncan, M.W. and Dean, R.T. (1993) Protein-bound 3,4-dihydroxyphenylalanine is a major reductant formed during hydroxyl radical damage to proteins, Biochemistry 32, 4780–4786.
Davies, MJ., Fu, S. and Dean, R.T. (1995) Protein hydroperoxides can give rise to reactive free radicals, Biochem. J. 305, 643–649.
Fu, S., Hick, L.A., Sheil, M.M. and Dean, R.T. (1995) Structural identification of valine hydroperoxides and hydroxides on radical-damaged amino acid, peptide and protein molecules, Free Rad. Biol. Med. 19, 281–292.
Wolff, S.P. (1994) Ferrous ion oxidation in the presence of ferric ion indicator xylenol orange for measurement of hydroperoxides, Methods Enzymol. 233, 182–189.
Buettner, G.R. (1987) Spin trapping: ESR parameters of spin adducts, Free Rad. Biol. Med. 3, 259–303.
Bilski, P., Chignell, C.F., Szychlinski, J., Borkowski, A., Oleksy, E. and Reszka, K (1992) Photooxidation of organic and inorganic substrates during UV photolysis of nitrite anion in aqueous solution, J. Am. Chem. Soc. 114, 549–556.
Basiuk, V.A., Gromovoy, T.Y, Chiuko, A.A., Soloshonok, V.A. and Kukhar, V.P. (1992) A novel approach to the synthesis of symmetric optically active 2,5dioxopiperazines, Synthesis, 449–451.
Fu, S., Gebicki, S., Jessup, W., Gebicki, J.M. and Dean, R.T. (1995) Biological fate of amino acid, peptide and protein hydroperoxides, Biochem. J. 311, 821–827.
Soszynski, M., Filipiak, A., Bartosz, G. and Gebicki, J.M. (1996) Effect of amino acid peroxides on the erythrocyte, Free Rad. Biol. Med. 20, 45–51.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Davies, M.J. (1997). Radicals Derived from Amino Acid and Protein Hydroperoxides — Key Mediators in Protein Damage ?. In: Minisci, F. (eds) Free Radicals in Biology and Environment. NATO ASI Series, vol 27. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-1607-9_18
Download citation
DOI: https://doi.org/10.1007/978-94-017-1607-9_18
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-481-4831-8
Online ISBN: 978-94-017-1607-9
eBook Packages: Springer Book Archive