Control of Cardiac Contraction by SR Ca Release and Sarcolemmal Ca Fluxes

  • Donald M. Bers
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 122)


In the preceding chapters the importance of both Ca current and SR Ca release in E-C coupling have been discussed and it was suggested that Ca from both sources could contribute to the activation of contraction. A major goal of this chapter is to clarify how these two sources of Ca may differ in particular cardiac muscle preparations and under different experimental situations. I will also discuss how the transsarcolemmal Ca fluxes and the SR Ca fluxes interact in a simple framework of overall Ca regulation in cardiac muscle.


Mechanical Restitution Rabbit Ventricle Biphasic Contraction Cardiac Muscle Preparation Rest Potentiation 
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Copyright information

© Springer Science+Business Media Dordrecht 1993

Authors and Affiliations

  • Donald M. Bers
    • 1
  1. 1.Department of PhysiologyLoyola University Medical SchoolMaywoodUSA

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