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Neuropathologic Features and Grading of Alzheimer-Related and Sporadic CAA

  • Harry V. Vinters
  • Jean-Paul G. Vonsattel
Chapter

Abstract

This chapter will consider neuropathologic features of CAA, an approach to grading the severity of CAA using straightforward morphologic criteria, and consequences of CAA in the brain; especially cerebral hemorrhage. Specifically, we will evaluate the relationship between sporadic CAA and that related to Alzheimer disease, unique neuropathologie features of CAA-related brain hemorrhage, and introduce the concept of CAA-associated microangiopathies (CAA-AM, e.g. microaneurysms, secondary angiitis, etc.); lesions that may well be the proximate cause of brain hemorrhage. Approaches to studying CAA pathogenesis and CAA-AM will be discussed in relation to the basic biology of the cerebral microvessel wall and its components, aspects of which are taken up elsewhere in this volume.

Keywords

Alzheimer Disease Giant Cell Arteritis Cerebral Hemorrhage Cerebral Amyloid Angiopathy Alzheimer Disease Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2000

Authors and Affiliations

  • Harry V. Vinters
    • 1
  • Jean-Paul G. Vonsattel
    • 2
  1. 1.Department of Pathology & Laboratory Medicine, Brain Research Institute & Neuropsychiatric InstituteUCLA Medical CenterLos AngelesUSA
  2. 2.Department of Pathology and Neuroscience CenterMassachusetts General Hospital and Harvard Medical SchoolCharlestownUSA

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