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Multimodality in the Management of Adenocarcinoma of the Esophagus

  • Chapter
Barrett’s Esophagus

Abstract

Prior to 1980, due to the relatively low incidence of adenocarcinoma of the esophagus and the use of surgery as the primary modality of treatment, information regarding the efficacy of radiation in esophageal adenocarcinoma was limited. Reports in the literature as early as 1948, distinguish adenocarcinoma of the esophagus as a separate entity from the more commonly seen squamous cell carcinoma. A total of 18 cases of esophageal adenocarcinoma were reported in the literature pre-1980, which involved the use of radiation therapy (4 of which were treated preoperatively and 14 treated with radiotherapy alone). These earlier reports largely failed to report on the treatment schema or type of radiation used.

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References

  1. Law SY, Fok M, Cheng SW, et al, A comparison of the outcome after resection for squamous cell carcinoma and adenocarcinoma of the esophagus and cardia. Surg Gynecol Obstet. 1992; 175: 107–12.

    PubMed  CAS  Google Scholar 

  2. Morson BC, Belcher JR, Brit J Cancer 1952; 6: 127.

    Article  PubMed  CAS  Google Scholar 

  3. Allison PR, Johnstone AS, Thorax 1953; 8: 87.

    Article  PubMed  CAS  Google Scholar 

  4. Smithers DW, Adenocarcinoma of the oesophagus. Thorax 1956; 11: 227.

    Article  Google Scholar 

  5. Raphael HA, Ellis FH, Dockerty MB, Primary adenocarcinoma of the esophagus: 18 year review of the literature. Annuls of Surg 1966; 164 (3): 785–96.

    Article  CAS  Google Scholar 

  6. Turnbull AD, Goodner JT, Primary adenocarcinoma of the esophagus. Cancer 1968; 22 (5): 915–8.

    Article  PubMed  CAS  Google Scholar 

  7. Jernsrtrom P, Brewer LA, Primary adenocarcinoma of the mid-esophagus arising in ectopic gastric mucosa with associated hiatal hernia and reflux esophagitis (Dawson’s syndrome). Cancer 1970; 26 (6): 1343–8.

    Article  Google Scholar 

  8. Shafer RB, Adenocarcinoma in Barrett’s columnar-lined esophagus. Arch Surg 1971; 103: 411–3.

    Article  PubMed  CAS  Google Scholar 

  9. Bremner CG, Lynch VP, Ellis FH, Barrett’s esophagus: Congenital or Acquired? Surgery 1970; 68: 209–16.

    PubMed  CAS  Google Scholar 

  10. Danoff B, Cooper J, Klein M, Primary adenocarcinoma of the upper oesophagus. Clin Radiol. 1978; 29: 519–22.

    Article  PubMed  CAS  Google Scholar 

  11. Earlam R, Cunha-melo JR. Oesophageal squamous cell carcinoma: I. A critical review of surgery. Br J Surg 1980; 67: 381–90.

    Article  PubMed  CAS  Google Scholar 

  12. Whyte RI, Orringer MB, Surgery for carcinoma of the esophagus: The case for transhiatal esophagectomy. Sem Rad Oncol 1994; 4 (3): 146–56.

    Article  Google Scholar 

  13. Bosset JF, Gignoux M, Triboulet JP, Tiret E, Mantion G, Elias D, Lozach P, Oilier JC, Pavy JJ, Mercier M, Sahmoud T, Chemoradiotherapy followed by surgery compared with surgery alone in squamous cell cancer of the esophagus. NEJM 1997; 337 (3); 161–7.

    Article  PubMed  CAS  Google Scholar 

  14. Walsh TN, Noonan N, Hollywood D, Kelly A, Kelling N, Hennessy TPJ A comparison of multimodality therapy and surgery for esophageal adenocarcinoma. NEJM 1996; 335 (7): 462–7.

    Article  PubMed  CAS  Google Scholar 

  15. Urba S, Orringer M, Turrisi A, Whyte R, Iannettoni M, Forastiere A, A randomized trial comparing surgery to preoperative concomitant chemoradiation plus surgery in patients with resectable esophageal cancer: updated analysis. Proc Am Soc Clin Oncol 1997; 16: 277a.

    Google Scholar 

  16. Kelsen DP, Ginsberg R, Pajak TF, Sheahan DG, Gunderson L, Mortimer J, Estes N, Haller DG, Ajani J, Kocha W, Minsky BD, Roth JA, Chemotherapy followed by surgery compared with surgery alone for localized esophageal cancer. NEJM 1998; 339 (27): 1979–84.

    Article  PubMed  CAS  Google Scholar 

  17. Amott Si, Duncan W, Kerr GR, et al Low dose preoperative radiotherapy for carcinoma of the oesophagus: results of a randomized trial. Radiotherapy and Oncol. 1992; 24: 108–13.

    Article  Google Scholar 

  18. Fok M, Sham JS, Choy D, Cheng S, Wong J, Postoperative radiotherapy for carcinoma of the esophagus: A prospective, randomised controlled study. Surgery 1993;113(2)138–147.

    Google Scholar 

  19. Whittington R, Coia LR, Haller DG, Rubenstein JH, Rosato EF, Adenocarcinoma of the esophagus and esophago-gastric junction: The effects of single and combined modalities on the survival and patterns of failure following treatment. IJROBP 1990; 19: 593–603.

    CAS  Google Scholar 

  20. Forastiere A, Orringer MB, Perez-Tamayo, C, Urba SG, Zahurak M, Preoperative chemoradiation followed by transhiatal esophagectomy for carcinoma of the esophagus:Final report. J Clin. Oncol. 1993; 11: 111–823.

    Google Scholar 

  21. Kavanagh B, Anscher M, Leopold K, Deutsch M, Gaydica E, Dodge R, Allen K, Allen D, Staub W, Montana G, Crawford J, Wolfe W, Patterns of failure following combined modality therapy for esophageal cancer, 1984–1990 IJROBP 1992; 24: 633–42.

    CAS  Google Scholar 

  22. Forastiere A, Heitmiller DJ, Lee R, Abrams R, Zahuarak M, A 4 week intensive preoperative chemoradiation program for locoregional cancer of the esophagus. Proc Am Soc Clin Oncol. 1994; 13: 195a.

    Google Scholar 

  23. Urba SG, Orringer MB, Perez-Tamayo C, Bromberg J, Forastiere A, Concurrent preoperative chemotherapy and radiation therapy in localized esophageal carcinoma. Cancer 1991; 69 (2): 285–91.

    Article  Google Scholar 

  24. Denham JW, Burmeister BH, Lamb DS, Spry NA, Joseph Dj, Hamilton CS, Yeoh E, O’Brien P, Walker QJ, Factors influencing outcome following radio-chemotherapy for oesophageal cancer Radiotherapy and Oncology 1996; 40: 31–43.

    Article  CAS  Google Scholar 

  25. Keller SM, Ryan L, Coia LR, Dang P, Vaught DJ, Diggs C, Weiner LM, Benson AB, High dose chemoradiotherapy followed by esophagectomy for adenocarcinoma of the esophagus and gastroesophageal junction. Cancer 1998; 83 (9): 1908–16.

    Article  PubMed  CAS  Google Scholar 

  26. Coia LR, Engstrom PF, Paul A, Nonsurgical management of esophageal cancer: Report of a study of combined radiotherapy and chemotherapy. JCO 1987; 5 (11): 1783–90.

    CAS  Google Scholar 

  27. Coia LR, Engstrom PF, Paul AR, Stafford PM, Hanks GE, Long term results of infusional 5-FU, Mitomycin-C, and radiation as primary management of esophageal carcinoma. IJROBP 1991; 20: 29–36.

    CAS  Google Scholar 

  28. Algan O, Coia LR, Keller SM, Engstrom PF, Weiner LM, Schultheiss TE, Hanks GE, Management of adenocarcinoma of the esophagus with chemoradiation alone or chemoradiation followed by esophagectomy: results of sequential nonrandomized phase II studies. IJROBP 1994; 32: 753–61.

    Google Scholar 

  29. Herskovic A, Martz K, Al-San-af M, Leichman L, Brindle J, Vaitkevicius V, Cooper J, Byhardt R, Davis L, Emami B, Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus. NEJM 1992; 326 (24): 1593–8.

    Article  PubMed  CAS  Google Scholar 

  30. Al-Sarraf M, Martz K, Herskovic A, Leichman L, Brindle JS, Vaitkevicious V, Cooper J, Bryhardt R, Davis L, Emami B, Progress report of combined chemoradiotherapy versus radiothrapy alone in patients with esophageal cancer: an intergroup study. JCO 1997; 15 (1): 277–84.

    CAS  Google Scholar 

  31. Langer M, Choi NC, Orlow E, Radiation therapy alone or in combination with surgery in the treatment of carcinoma of the esophagus. Cancer 1986; 58: 1208–13.

    Article  PubMed  CAS  Google Scholar 

  32. Wara WM, Mauch PM, Thomas AN, Palliation for adenocarcinoma of the esophagus. Radiology 1976; 121, 717–720.

    PubMed  CAS  Google Scholar 

  33. Caspers RJL, Welvaart K, Verkes RJ, The effect of radiotherapy on dysphagia and survival in patients with esophageal cancer. Radiother Oncol 1988; 12: 15–23.

    Article  PubMed  CAS  Google Scholar 

  34. O’Rourke IC, Tiver K, Bull C, Swallowing performance after radiation therapy for carcinoma of the esophagus. Cancer 1988; 61: 2022–6.

    Article  PubMed  Google Scholar 

  35. Coia LR, Soffen EM, Schultheiss TE, Martin EE, Hanks GE, Swallowing function in patients with esophageal cancer treated with concurrent radiation and chemotherapy. Cancer 1993; 71 (2): 281–5.

    Article  PubMed  CAS  Google Scholar 

  36. Gaspar LE, Qian C, Kocha WI, Coia LR, Herskovic A, Graham M, A phase I/Ii study of external beam irradiation, brachytherapy and concurrent chemotherapy in localized cancer of the esophagus (RTOG 92–07): Preliminary toxicity report. IJROBP 1997; 37 (3): 593–9.

    CAS  Google Scholar 

  37. Gaspar LE, Nag S, Herskovic A, Mantravadi R, Speiser B, Clinical research committee ABS, American Brachyterapy Society (ABS) consensus guidelines for brachytherapy of esophageal cancer. IJROBP 1997; 38 (1): 127–32.

    CAS  Google Scholar 

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© 2001 Springer Science+Business Media Dordrecht

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DeNittis, A.S., Whittington, R., Coia, L. (2001). Multimodality in the Management of Adenocarcinoma of the Esophagus. In: Tilanus, H.W., Attwood, S.E.A. (eds) Barrett’s Esophagus. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0829-6_30

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  • DOI: https://doi.org/10.1007/978-94-017-0829-6_30

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-5860-7

  • Online ISBN: 978-94-017-0829-6

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