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Animal models of atherosclerosis

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Animal models in cardiovascular research

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 153))

Abstract

Atherosclerosis is a pathological process which primarily occurs in large conduit arteries. There are focal accumulations of; cells within the intima of the artery, both intra- and extra-cellular lipids, fibrous connective tissue, complex proteoglycans, minerals, blood and blood products. As the disease progresses necrosis often occurs, especially at the base of the lesion, along with damage to the media of the vessel, ulceration and eventually thrombosis.1 The disease is thought to occur when the influx and deposition of cholesterol into the wall exceeds the elimination from the wall, i.e. the process is continuous and dynamic The cholesterol that is deposited seems to be derived from specific types of plasma lipoproteins. The mechanism(s) of deposition probably involve oxysterol metabolism as well. Other types of plasma lipoproteins may be able to participate in the elimination processes which mobilize cholesterol from the arterial cells and transport it to the liver for elimination.2

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Authors and Affiliations

  1. Cardiovascular and Thoracic, Surgery Research Labs, University of Kentucky, Lexington, Kentucky, USA

    David R. Gross DVM, PhD (Professor & Director)

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  1. David R. Gross DVM, PhD
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© 1994 Springer Science+Business Media Dordrecht

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Gross, D.R. (1994). Animal models of atherosclerosis. In: Animal models in cardiovascular research. Developments in Cardiovascular Medicine, vol 153. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0730-5_12

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  • DOI: https://doi.org/10.1007/978-94-017-0730-5_12

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-017-0732-9

  • Online ISBN: 978-94-017-0730-5

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