Abstract
It has been well documented that oral administration of protein antigens commonly induces systemic immunological unresponsiveness to subsequent parenteral immunization, which is termed oral tolerance [1, 2]. Although this phenomenon is thought to be an immune regulation system preventing food hypersensitivity in healthy individuals, the overall mechanisms underlying the induction of oral tolerance and the onset of food allergy are not still well clarified. In this study, groups of mice were orally given with raw or heated cow’s milk for a period of up to 2 months prior to intraperitoneal injections with bovine β -lactoglobulin (β -Lg), one of the most potent cow’s milk allergens [3]. Using this experimental system, we examined and compared the magnitude and epitope specificity of immunological tolerance observed in each group of the mice.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Weiner, H. L.: Oral tolerance: immune mechanisms and treatment of autoimmune diseases, Immunol. Today 18 (1997), 335–343.
Stnobel, S. and Mowat, A. M.: Immune responses to dietary antigens: oral tolerance, Immunol Today 19 (1998), 173–181.
Kaminogawa, S. and Enomoto, A .: Immunological properties of cow’s milk allergens, Comments Agric. & Food Chemistry 2 (1992), 321–337.
Shon, D.-HL, Enomoto, A., Yamauchi, K. and Kaminogawa, S.: Antibodies raised against peptide fragments of bovine a si-casein cross-react with the native protein, but recognize sites distinct from the determinants on the protein, Eur. J. Immunol. 21 (1991), 1475–1480.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer Science+Business Media Dordrecht
About this paper
Cite this paper
Enomoto, A., Koyahara, S., Harada, H., Komine, S. (2003). Epitope-Specific Suppression of Immune Response Against β-Lactoglobulin Induced by Oral Administration of Cow’s Milk with Heat Treatments. In: Yagasaki, K., Miura, Y., Hatori, M., Nomura, Y. (eds) Animal Cell Technology: Basic & Applied Aspects. Animal Cell Technology: Basic & Applied Aspects, vol 13. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0726-8_44
Download citation
DOI: https://doi.org/10.1007/978-94-017-0726-8_44
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-481-6557-5
Online ISBN: 978-94-017-0726-8
eBook Packages: Springer Book Archive