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Suppression of glutamate-induced neural cell death by electrolyzed-reduced water

  • T. Kashiwagi
  • T. Hamasaki
  • M. Takaki
  • S. Kabayama
  • K. Teruya
  • Y. Katakura
  • K. Otubo
  • S. Morisawa
  • S. Shirahata
Conference paper
Part of the Animal Cell Technology: Basic & Applied Aspects book series (ANICELLTECH, volume 13)

Abstract

Electrolyzed-reduced water (ERW) produced by electrolyzing water in cathode side has the ability to scavenge reactive oxygen species (ROS). Here, we investigated the effect of ERW on oxidative stress-induced neural cell death by glutamate. When cell viability assay was performed using primary rat cerebral cortical culture as neural model, ERW suppressed neural cell death by glutamate. Furthermore, intracellular ROS levels were reduced by ERW, suggesting that suppressive effect of ERW on the glutamate-induced neural cell death was due to the suppression of glutamate-induced ROS augmentation by ERW.

Keywords

Nitric Oxide Intracellular Reactive Oxygen Species Cytosine Arabinoside Intracellular Reactive Oxygen Species Level Primary Cortical Culture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2003

Authors and Affiliations

  • T. Kashiwagi
    • 1
  • T. Hamasaki
    • 1
  • M. Takaki
    • 1
  • S. Kabayama
    • 2
  • K. Teruya
    • 1
  • Y. Katakura
    • 1
  • K. Otubo
    • 2
  • S. Morisawa
    • 2
  • S. Shirahata
    • 1
  1. 1.Department of Genetic Resources TechnologyKyushu UniversityFukuokaJapan
  2. 2.Nihon Trim Co. LTD.OsakaJapan

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