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Aging of the Gastrointestinal System

  • Chapter
Aging of the Organs and Systems

Part of the book series: Biology of Aging and Its Modulation ((BIMO,volume 3))

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Abstract

All multicellular organisms undergo change with time. This concept of aging may be considered in different ways. The maximum life span and the average life span are two commonly used definitions. The process of aging must take into account social, biological, physiological, emotional, socioeconomic, as well as cellular and molecular changes. Aging is a multifactorial conditional with environmental and genetic factors. While chronological age is easy to measure, biological age is a better marker of health status that allows for the concept of the introduction of processes to ameliorate the aging process, thereby compressing morbidity, improving competence, well being, and quality of life [1].

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References

  1. Balcolm NR, Sinclair A (2001). Ageing: definitions, mechanisms and the magnitude of the problem [Review]. Best Pract Res Clin Gastroenterol. 15: 835–49.

    Google Scholar 

  2. Fries JF (1980). Ageing, natural death and the compression of morbidity. NEngl JMed. 303: 130–6.

    CAS  Google Scholar 

  3. Jagger C (1997). Using healthy active life expectancy to measure population outcomes. In: Philip I, ed. Outcomes Assessment for Healthcare in Elderly People. London: Farrand Press, pp. 67–76.

    Google Scholar 

  4. Russell RM (1992). Associated changes in gastrointestinal function attributed to aging Am JNutr. 56: 1203–7.

    Google Scholar 

  5. Sklar M (1983). Gastrointestinal diseases in the aged. In: Reichel W, ed. Clinical Aspects of Aging. Baltimore: Williams & Wilkins, pp. 205–17.

    Google Scholar 

  6. Sklar M, Kirsner JB (2001). Assessing and interviewing the elderly interpretation of signs and symptoms. Best Pract Res Clin Gastroenterol. 15: 851–67.

    PubMed  CAS  Google Scholar 

  7. Tierney AJ (1996). Undernutrition and elderly hospital patients: a review. JAdv Nurs. 23: 228–36.

    CAS  Google Scholar 

  8. Beck AM, Ovesen L, Osler M (1999). The ‘Mini Nutritional Assessment’ (MNA) and the ‘Determine Your Nutritional Health’ Checklist ( NSI Checklist) as predictors of morbidity and mortality in an elderly Danish population. Br JNutr. 81: 31–6.

    Google Scholar 

  9. Lehmann AB, Bassey EJ, Morgan K, Dalosso HM (1991). Normal values for weight, skeletal size and body mass indicies in 890 men and women aged over 65 years. Clin Nutr. 10: 18–22.

    PubMed  CAS  Google Scholar 

  10. Morley JE (1997). Anorexia of ageing: physiologic and pathologic. Am J Clin Nutr. 66: 760–73.

    PubMed  CAS  Google Scholar 

  11. Volkert D, Hubsch S, Oster P, Schlierf G (1996). Nutritional support and functional status in undernourished geriatric patients during hospitalization and 6-month follow-up. Aging (Milano) 8: 386–95.

    CAS  Google Scholar 

  12. Pirlich M, Lochs H (2001). Nutrition in the elderly. Best Pract Res Clin Gastroenterol. 15: 869–84.

    PubMed  CAS  Google Scholar 

  13. Kondo JJL, Blaschke TF (1989). Drug-drug interactions in geriatric patients. In: Platt D, ed. Gerontology Berlin: Springer Verlag, pp. 257–69.

    Google Scholar 

  14. Le Couteur DG, McLean AJ (1998). The aging liver. Drug clearance and an oxygen diffusion barrier hypothesis. Clin Pharmcokinet 34: 359–73.

    Google Scholar 

  15. Schmucker DL (1998). Aging and the liver: an update. J Gerontol: Biol Sci 53A: B315–20.

    CAS  Google Scholar 

  16. Herrlinger C, Klotz U (2001). Drug metabolism and drug interactions in the elderly. Best Pract Res Clin Gastroenterol. 15: 897–918.

    PubMed  CAS  Google Scholar 

  17. Ammon S, Treiber G, Kees F, Klotz U (2000). Influence of age on the steady state disposition of drugs commonly used for the eradication of Helicobacter pylori. Aliment Pharmaco Ther. 14: 759–66.

    CAS  Google Scholar 

  18. Feely J, Pereira L, Guy E, Hockings N (1984). Factors affecting the response to inhibition of drug metabolism by cimetidine dose response and sensitivity of elderly and induced subjects. Br J Clin Pharmacol. 17: 77–81.

    PubMed  CAS  Google Scholar 

  19. Andersson T, Andren K, Cederberg C (1990). Effect of omeprazole and cimetidine on plasma diazepam levels. Eur J Clin Pharmacol. 39: 51–4.

    PubMed  CAS  Google Scholar 

  20. Budtz-Jorgensen E, Chung J-P, Rapin CH (2001). Nutrition and oral health. Best Pract Res Clin Gastroenterol. 15: 885–96.

    PubMed  CAS  Google Scholar 

  21. Shaker R, Ren J, Podvrsan B (1993). Effect of aging and bolus variables on pharyngeal and upper esophageal sphincter motor function. Am JPhysiol. 264: G427–32.

    CAS  Google Scholar 

  22. Kern M, Bardan E, Arndorfer R, Hofmann C, Ren J, Shaker R (1999). Comparison of upper esophageal sphincter opening in healthy asymptomatic young and elderly volunteers. Ann Otol Rhinol Laryngol. 108: 982–9.

    PubMed  CAS  Google Scholar 

  23. Shaw DW, Cook IJ, Gabb M (1995). Influence of normal aging on oral-pharyngeal and upper esophageal sphincter function during swallowing. Am JPhysiol. 268: G389–96.

    CAS  Google Scholar 

  24. Ekberg O, Feinberg MJ (1991). Altered swallowing function in elderly patients without dysphagia: radiologic findings in 56 cases. Am JRoentgenol. 156: 1181–4.

    CAS  Google Scholar 

  25. Tack J, Vantrappen G (1997). The aging oesophagus. Gut 41: 422–4.

    PubMed  CAS  Google Scholar 

  26. Grande L, Lacima G, Ros E, et al. (1999). Deterioration of esophageal motility with age: a manometric study of 79 healthy subjects. Am JGastroenterol. 94: 1795–801.

    CAS  Google Scholar 

  27. Adamek RJ, Wegener M, Weinbeck M, Gielen B (1994). Long-term esophageal manometry in healthy subjects. Evaluation of normal values and influence of age. Dig Dis Sci. 39: 2069–73.

    Google Scholar 

  28. Ferriolli E, Oliveira RB, Matsuda NM (1998). Aging, esophageal motility, and gastroesophageal reflux. JAm Geriatr Soc. 46: 1534–7.

    CAS  Google Scholar 

  29. Lock G (2001). Physiology and pathology of the oesophagus in the elderly patient. Best Pract Res Clin Gastroenterol. 15: 919–41.

    PubMed  CAS  Google Scholar 

  30. Collen MJ, Abdulian JD, Chen YK (1995). Gastroesophageal reflux disease in the elderly: more severe disease that requires aggressive therapy. Am J Gastroenterol. 90: 1053–7.

    PubMed  CAS  Google Scholar 

  31. Pilotto A, Franceschi M, Leandro G, et al. (2002a). Influence of Helicobacter pylori infection on severity of oesophagitis and response to therapy in the elderly. Dig Liver Dis. 34: 328–31.

    PubMed  CAS  Google Scholar 

  32. Simmons DB, Schuman BM, Griffon JW (1997). Achalasia in patients over 65. JFlorida Med Assoc. 84: 101–3.

    CAS  Google Scholar 

  33. Pasricha PJ, Ravich WJ, Hendrix TR (1995). Intrasphincteric botulinum toxin for the treatment of achalasia. NEngl JMed. 332: 774–8.

    CAS  Google Scholar 

  34. Hallett M (1999). One man’s poison clinical applications of botulinum toxin. NEngl J Med. 341: 118–20.

    CAS  Google Scholar 

  35. Pandolfino JE, Howden CW, Kahrilas PJ (2000). Motility-modifying agents and management of disorders of gastrointestinal motility. Gastroenterology 118: S32–47.

    PubMed  CAS  Google Scholar 

  36. Pilotto A, Franceshi M, Leandro G, Novello R, Di Mario F, Valerio G (2002b). Longterm clinical outcome of elderly patients with relfux esophagitis: a six-month to three-year follow-up study. Am JTher. 9: 295–300.

    Google Scholar 

  37. Wong J (1981). Management of carcinoma of the esophagus. Ann Royal Coll Surg Engl. 26: 138–49.

    CAS  Google Scholar 

  38. de la Mora G, Marcon NE (2001). Endoscopy in the elderly patient. Best Pract Res Clin Gastroenterol. 15: 999–1012.

    PubMed  CAS  Google Scholar 

  39. Seinela L, Ahvenainen J (2000). Peptic Ulcer in the very old patients. Gerontology 4: 271–5.

    Google Scholar 

  40. Phillips AC, Polisson RP, Simon LS (1997). NSAIDs and the elderly. Toxicity and economic implications. Drugs Aging 10: 119–30.

    Google Scholar 

  41. Bode G, Brenner H, Adler G, Rothenbacher D (2002). Dyspeptic symptoms in middle-aged to old adults: the role of Helicobacter pylori infection, and various demographic and lifestyle factors. JIntern Med. 252: 41–7.

    CAS  Google Scholar 

  42. Pilotto A, Franceschi M, Leandro G, et al. (1999). Efficacy of 7 day lansoprazole-based triple therapy for Helicobacter infection in elderly patients. JGastroenterol Hepatol. 14: 468–75.

    CAS  Google Scholar 

  43. Graham DY, Malaty HM, Evans DG, Evans DJ, Klein PD, Adam E (1991). Epidemiology of Helicobacter pylori in an asymptomatic population in the United States. Effect of age, race and socioeconomic status. Gastroenterology 100: 1495–501.

    Google Scholar 

  44. Kemppainen H, Raiha I, Kujari H, Sourander L (1998). Characteristics of Helicobacter pylori-negative and -positive peptic ulcer disease. Age Ageing 27: 427–31.

    PubMed  CAS  Google Scholar 

  45. Jones JIW, Hawkey CJ (2001). Physiology and organ-related pathology of the elderly: stomach ulcers. Best Pract Res Clin Gastroenterol. 15: 943–61.

    PubMed  CAS  Google Scholar 

  46. Haruma K, Kamada T, Kawaguchi H (2000). Effect of age and Helicobacter pylori infection on gastric acid secretion. JGastroenterol Hepatol. 15: 277–83.

    CAS  Google Scholar 

  47. Kinoshita Y, Kawanami C, Kishi K (1997). Helicobacter pylori independent chronological change in gastric acid secretion in the Japanese. Gut, 41: 452–8.

    PubMed  CAS  Google Scholar 

  48. Cryer B, Redfern JS, Goldschmiedt M (1992). Effect of aging on gastric and duodenal mucosal prostaglandin concentrations in humans. Gastroenterology 102: 1118–23.

    PubMed  CAS  Google Scholar 

  49. Goto H, Sugiyama S, Ohara A (1992). Age-associated decreases in prostaglandin contents in human gastric mucosa. Biochem Biophys Res Comm. 186: 1443–8.

    PubMed  CAS  Google Scholar 

  50. Del Vecchio B, Domenico T (1993). Italian Multicenter Study Group for gastric ulcer. Can advanced age influence the characteristics of peptic gastric ulcer? Gastrointest Endo. 39: 50–3.

    Google Scholar 

  51. Kemppainen H, Raiha I, Sourander L (1997). Clinical presentation of peptic ulcer in the elderly. Gerontology 43: 283–8.

    PubMed  CAS  Google Scholar 

  52. Hawkey CJ (2001). Gastrointestinal toxicity of non-steroidal anti-inflammatory drugs. In: Vane JR, Botting RM, eds. Therapeutic Roles of Selective COX-2 Inhibitors. London: William Harvey Press, pp. 355–94.

    Google Scholar 

  53. Gabriel SE, Jaakkimainen L, Bombardier C (1991). Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs. A meta-analysis. Ann Intern Med. 115: 787–96.

    Google Scholar 

  54. Pilotto A, Franceschi M, Di Mario F (1998a). The long-term clinical outcome of elderly patients with Helicobacter pylori-associated peptic ulcer disease. Gerontology 44: 153–8.

    PubMed  CAS  Google Scholar 

  55. Pilotto A, Di Mario F, Franceschi M (2000a). Treatment of Helicobacter pylori infection in elderly subjects. Age Ageing 29: 103–9.

    PubMed  CAS  Google Scholar 

  56. Pilotto A, Malfertheiner P (2002). An approach to Helicobacter pylori infection in the elderly. Aliment Pharmaco Ther. 16: 683–91.

    CAS  Google Scholar 

  57. Hawkey CJ, Karrasch JA, Szczepanski (1998). Omeprazole versus misoprostol for NSAID-induced ulcer management (OMNIUM) study group. Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. N Engl JMed. 338: 727–34.

    Google Scholar 

  58. Pilotto A, Di Mario F, Franceschi M, et al. (2000b). Pantoprazole versus one-week Helicobacter pylori eradication therapy for the prevention of acute NSAID-related gastroduodenal damage in elderly subjects. Aliment Pharmacol Ther. 14: 1077–82.

    PubMed  CAS  Google Scholar 

  59. Koop H, Arnold R, Classen M (1992). The RUDER Study Group. Healing and relapse of duodenal ulcer during ranitidine therapy in the elderly. J Clin Gastroenterol. 15: 291–5.

    Google Scholar 

  60. Rockall TA, Logan RF, Devlin HB, Northfield TC (1996). Risk assessment after acute upper gastrointestinal haemorrhage. Gut 38: 316–21.

    PubMed  CAS  Google Scholar 

  61. Longstreth GF (1997). Epidemiology and outcome of patients hospitalized with acute lower gastrointestinal haemorrhage: a population-based study. Am J Gastroenterol. 92: 419–24.

    PubMed  CAS  Google Scholar 

  62. Cooper BT, Weston CF, Neumann CS (1988). Acute upper gastrointestinal haemorrhage in patients aged 80 years or more. Q JMed. 68: 765–74.

    CAS  Google Scholar 

  63. Hasselgren G, Blomqvist A, Eriksson S (1998). Short and long-term course of elderly patients with peptic ulcer bleeding analysis of factors influencing fatal outcome. Eur J Surg. 164: 685–91.

    PubMed  CAS  Google Scholar 

  64. Hudson N, Faulkner G, Smith SJ (1995). Late mortality in elderly patients surviving acute peptic ulcer in bleeding. Gut 37: 177–81.

    PubMed  CAS  Google Scholar 

  65. Chow LWC, Gertsch P, Poon RTP, Branicki FJ (1998). Risk factors for rebleeding and death from peptic ulcer in the very elderly. Br JSurg. 85: 121–4.

    CAS  Google Scholar 

  66. Battaglia G, Di Mario F, Dotto P (1993). markers of slow-healing peptic ulcer in the elderly. A study on 1,051 ranitidine-treated patients. Dig Dis Sci. 38: 1414–21.

    Google Scholar 

  67. Watson RJ, Hooper TL, Ingram G (1985). Duodenal ulcer disease in the elderly: a retrospective study. Age Ageing 14: 225–9.

    PubMed  CAS  Google Scholar 

  68. Hasselgren G, Lind T, Lundell L (1997). Continuous intravenous infusion of omeprazole in elderly patients with peptic ulcer bleeding. Results ofa placebo-controlled multicenter study. Scand JGastroenterol. 32: 328–33.

    Google Scholar 

  69. Lingenfelser T, Ell C (2001). Gastrointestinal bleeding in the elderly. Best Pract Res Clin Gastroenterol. 15: 963–82.

    PubMed  CAS  Google Scholar 

  70. Segal WN, Cello JP (1997). Haemorrhage in the upper gastrointestinal tract in the older patient. Am J Gastroenterol. 92: 42–6.

    PubMed  CAS  Google Scholar 

  71. O’Riordain DS, O’Dwyer PJ, O’Higgins NJ (1990). Perforated duodenal ulcer in elderly patients. JRoyal Coll Surg Edinburgh 35: 93–4.

    Google Scholar 

  72. Kane E, Fried G, McSherry CK (1981). Perforated peptic ulcer in the elderly. JAm Geriatr Soc. 29: 224–7.

    CAS  Google Scholar 

  73. Kum CK, Chong YS, Koo CC, Rauff A (1993). Elderly patients with perforated peptic ulcers: factors affecting morbidity and mortality. JRoyal Coll Surg Edinburg 38: 344–7.

    CAS  Google Scholar 

  74. Peter DJ, Dougherty JM (1999). Evaluation of the patient with gastrointestinal bleeding: an evidence based approach. Emerg Med Clin NAm 17: 239–61.

    CAS  Google Scholar 

  75. Farrell JJ, Friedman LS (2000). Gastrointestinal bleeding in older people. Gastroenterol Clin NAm. 29: 1–36.

    CAS  Google Scholar 

  76. Vreeburg EM, Snel P, de Bruijne JW (1997). Acute upper gastrointestinal bleeding in the Amsterdam area: incidence, diagnosis, and clinical outcome. Am J Gastroenterol. 1997: 236–43.

    Google Scholar 

  77. Terdiman JP (1998). Update on upper gastrointestinal bleeding. Postgrad Med. 103: 43–63.

    PubMed  CAS  Google Scholar 

  78. Cappell MS, Abdullah M (2000). Management of gastrointestinal bleeding induced by gastrointestinal endoscopy. Gastroenterol Clin NAm. 29: 125–67.

    CAS  Google Scholar 

  79. Simoens M, Gevers AM, Rutgeerts P (1999). Endoscopic therapy for upper gastrointestinal haemorrhage: a state of the art. Hepatogastroenterology 46: 737–45.

    PubMed  CAS  Google Scholar 

  80. Stollman NH, Raskin JB (1999). Diverticular disease of the colon. J Clin Gastroenterol. 29: 241–52.

    PubMed  CAS  Google Scholar 

  81. Foutch PG (1995). Diverticular bleeding: are nonsteroidal anti-inflammatory drugs risk factors for haemorrhage and can colonoscopy predict outcome for patients? Am J Gastroenterol. 90: 1779–84.

    PubMed  CAS  Google Scholar 

  82. Sorbi D, Norton I, Conio M (2000). Postopolypectomy lower GI bleeding: descriptive analysis. Gastrointest Endosc. 51, 690–6.

    PubMed  CAS  Google Scholar 

  83. Lau JYW, Sung JJY, Lee KKC (2000). Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcer. NEngl JMed. 343: 310–16.

    CAS  Google Scholar 

  84. Rosen A (1999). Gastrointestinal bleeding in the elderly. Clin Geriatr Med. 15: 511–25.

    PubMed  CAS  Google Scholar 

  85. Lau JYW, Sung JJY, Lam YJ (1999). Endoscopic retreatment compared with surgery in patients with recurrent bleeding after initial endoscopic control of bleeding ulcers. N Engl JMed. 340: 751–6.

    CAS  Google Scholar 

  86. Hamilton SR, Aoltonen LA (2000). Tumours of the Digestive System. World Health Organization Classification of Tumours. Lyon: IARC Press.

    Google Scholar 

  87. Schlemper RJ, Riddell RH, Kato Y (2000). The Vienna classification of gastrointestinal epithelial neoplasia. Gut 47: 251–5.

    PubMed  CAS  Google Scholar 

  88. Meining A, Morgner A, Miehlke S, Bayerdorffer E, Stolte M (2001). Atrophymetaplasia-dysplasia-carcinoma sequence in the stomach: a reality or merely an hypothesis? Best Pract Res Clin Gastroenterol. 15: 983–98.

    PubMed  CAS  Google Scholar 

  89. Sugano H, Nakamura K, Kato Y (1982). Pathological studies on human gastric cancer. Acta Pathologica Japan 32 (Suppl 2): 329–47.

    Google Scholar 

  90. Sasaki I, Yao T, Nawate H, Tsuneyoshi M (1999). Minute gastric carcinoma of differentiated type with special reference to the significance of intestinal metaplasia, proliferative zone, and p53 protein during tumor development. Cancer 85: 1719–29.

    PubMed  CAS  Google Scholar 

  91. Pilotto A, Rassu M, Bozzola L, et al. (1998b). Cag-A positive Helicobacter pylori infection in the elderly. Association with gastric atrophy and intestinal metaplasia. J Clin Gastroenterol. 26: 18–22.

    Google Scholar 

  92. Blaser MJ, Perez-Perez GI, Kleantoustl, et al. (1995). Infection with Helicobacter pylori possessing cag A is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res. 55: 2111–5.

    PubMed  CAS  Google Scholar 

  93. Parsonnet J, Friedman GD, Orestrich N, et al. (1997). Risk of gastric cancer in people with Cag A positive or Cag A negative Helicobacter pylori infection. Gut 40: 297–301.

    PubMed  CAS  Google Scholar 

  94. Schulmann K, Reiser M, Schmiegel W (2002). colonic cancer polyps. Best Pract Res Clin Gastroenterol. 16: 91–114.

    Google Scholar 

  95. Rudman D (1989). Nutrition and fitness in elderly people. Am J Clin Nutr. 49: 1090–8.

    PubMed  CAS  Google Scholar 

  96. Kerstetter JE, Holthausen BA, Fitz PA (1992). Malnutrition in the institutionalized elderly adult. JAm Diet Assoc. 92: 1109–16.

    CAS  Google Scholar 

  97. Abbasi AA, Rudman D (1993). Observations on the prevalence of protein-calorie undernutrition in VA nursing homes. JAm Geriatr Soc. 41: 117–21.

    CAS  Google Scholar 

  98. Mowe M, Bohmer T, Kindt E (1994). Reduced nutritional status in an elderly population (>70 y) is probable before disease and possibly contributes to the development of disease. Am J Clin Nutr. 59: 317–24.

    PubMed  CAS  Google Scholar 

  99. Sullivan D, Walls RC (1994). Impact of nutritional status on morbidity in a population of geriatric rehabilitation patients. JAm Geriatr Soc. 42: 471–7.

    CAS  Google Scholar 

  100. Payette H, Coulombe C, Boutier V, Gray-Donald K (1999). Weight loss and mortality among the free-living frail elderly: a prospective study. JGerontol: Med Sci. 54A: M440–5.

    CAS  Google Scholar 

  101. Payette H, Gray-Donald K (1994). Risk of malnutrition in an elderly population receiving home care services. Facts and Research in Gastroenterology: Nutrition. Suppl 2: 71–85.

    Google Scholar 

  102. Sullivan DH, Patch GA, Walls RC, Lipschitz DA (1990). Impact of nutrition status on morbidity and mortality in a select population of geriatric rehabilitation patients Am J Clin Nutr. 51: 749–58.

    CAS  Google Scholar 

  103. Wallace JI, Schwartz RS, LaCroix AZ, et al. (1995). Involuntary weight loss in older outpatients: incidence and clinical significance. JAm Geriatr Soc. 43: 329–37.

    CAS  Google Scholar 

  104. Payette H, Gray-Donald K (1991). Dietary intake and biochemical indices of nutritional status in an elderly population, with estimates of the precision of the 7-d food record. JAm College Nutr. 54: 478–88.

    CAS  Google Scholar 

  105. McGandy RB, Russell RM, Hartz SC, et al. (1986). Nutritional status survey of healthy noninstitutionalized elderly: energy and nutrient intakes from three-day records and nutrient supplements. Nutr Res. 6: 785–98.

    Google Scholar 

  106. De Groot CPGM, Van Staveren WA, Dirren H, Hautvast JGAJ, eds. (1996). SENECA: Nutrition and the elderly in Europe. Follow-up study and longitudinal analysis. Eur J Clin Nutr. 50(Suppl 2): 1–124.

    Google Scholar 

  107. Azad N, Murphy J, Amos SS, Toppan J (1999). Nutrition survey in an elderly population following admission to a tertiary care hospital. Can Med Assoc J. 161: 511–15.

    CAS  Google Scholar 

  108. Feibusch JM, Holt PR (1982). Impaired absorptive capacity for carbohydrate in the aging human. Dig Dis Sci. 27: 1095–100.

    PubMed  CAS  Google Scholar 

  109. Riepe SP, Goldstein J, Alpers DH (1980). Effect of secreted Bacteroides proteases on human intestinal brush border hydrolases. J Clin Invest. 66: 314–22.

    PubMed  CAS  Google Scholar 

  110. Lee MF, Russell RM, Montgomery RK, Krasinski SD (1997). Total intestinal lactase and sucrase activities are reduced in aged rats. JNutr. 127: 1382–7.

    CAS  Google Scholar 

  111. Woudstra T, Thomson ABR (2002). Nutrient absorption and intestinal adaptation with ageing. Best Pract Res Clin Gastroenterol. 16: 1–15.

    PubMed  Google Scholar 

  112. Simko V, Michael S (1989). Absorptive capacity for dietary fat in elderly patients with debilitating disorders. Arch Intern Med. 149: 557–60.

    PubMed  CAS  Google Scholar 

  113. Salemans JM, Nagengast FM, Tangerman A (1993). Effect of ageing on postprandial conjugated and unconjugated serum bile acid levels in healthy subjects. Eur JClin Invest. 23: 192–8.

    CAS  Google Scholar 

  114. Arora S, Kassarjian Z, Krasinski SD (1989). Effect of age on tests of intestinal and hepatic function in healthy humans. Gastroenterology 96: 1560–5.

    PubMed  CAS  Google Scholar 

  115. Holt PR (2001). Diarrhea and malabsorption in the elderly. Gastroenterol Clin NAm. 30: 427–44.

    CAS  Google Scholar 

  116. Gersovitz M, Munro HN, Udall J, Young VR (1980). Albumin synthesis in young and elderly subjects using a new stable isotope methodology: response to level of protein intake. Metabolism 29: 1075–86.

    PubMed  CAS  Google Scholar 

  117. Bullamore JR, Wilkinson R, Gallagher JC, et al. (1970). Effect of age on calcium absorption. Lancet 2: 535.

    PubMed  CAS  Google Scholar 

  118. Morris HA, Nordin BEC, Fraser V (1985). Calcium absorption and serum 1,25 dihydroxy vitamin D levels in normal and osteoporotic women. Gastroenterology A1508.

    Google Scholar 

  119. Armbrecht HJ, Zenser TV, Bruns ME, Davis BB (1979). Effect of age on intestinal calcium absorption and adaptation to dietary calcium. Am JPhysiol. 236: E769–74.

    CAS  Google Scholar 

  120. Ebeling PR, Sandgren ME, DiMagno EP, Lane AW, DeLuca HF, Riggs BL (1992). Evidence ofan age-related decrease in intestinal responsiveness to vitamin D: relationship between serum 1,25 dihydroxyvitamin D-3 and intestinal vitamin D receptor concentrations in normal women. J Clin Endocrinol Metab. 75: 176–82.

    PubMed  CAS  Google Scholar 

  121. Said HM, Hollander D (1984). Does aging affect the intestinal transport of 5- methyltetrahydrofolate? Digestion 30: 231–5.

    PubMed  CAS  Google Scholar 

  122. Nilsson-Ehle H, Landahl S, Lindstedt G (1989). Low serum cobalamin levels in a population study of 70- and 75-year old subjects. Gastrointestinal causes and hematological effects. Dig Dis Sci. 34: 716–23.

    Google Scholar 

  123. Kinyamu HK, Gallagher JC, Knezetic JA, DeLuca HF, Prahl JM, Lanspa SJ (1997). Effect of vitamin D receptor genotypes on calcium absorption, duodenal vitamin D receptor concentration, and serum 1,25 dihydroxyvitamin D levels in normal women. Calcif Tiss Int. 60: 491–5.

    CAS  Google Scholar 

  124. Kassarjian Z, Russell RM (1989). Hypochlorhydria: a factor in nutrition. Annu Rev Nutr. 9: 271–85

    PubMed  CAS  Google Scholar 

  125. Stampfer MJ, Malinow MR, Willet WC, et al. (1992). A prospective study of plasma homocysteine and risk of myocardial infarction in US physicians. JAm Med Assoc. 268: 877–81.

    CAS  Google Scholar 

  126. Selhub J, Jaques PF, Bostom AG, et al. (1995). Association between plasma homocysteine concentrations and extracranial carotid-artey stenosis. NEngl JMed. 332: 226–91.

    Google Scholar 

  127. Riggs KM, Spiro A III, Tucker K, Rush D (1996). Relations of vitamins B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the normative ageing study. Am J Clin Nutr. 63: 306–14.

    PubMed  CAS  Google Scholar 

  128. Corazza GR, Ginaldi L, Ouaglione G (1998). Proliferation cell nuclear antigen expression is increased I small bowel epithelium in the ederly. Mech Ageing Dev. 104: 1–9.

    PubMed  CAS  Google Scholar 

  129. Ciccocioppo R, Di Sabatino A, Luinetti O, et al. (2002). Small bowel enterocyte apoptosis and proliferation are increased in the elderly. Gerontology 48 (4): 204–8.

    PubMed  CAS  Google Scholar 

  130. Warren PM, Pepperman MA, Montgomery RD (1978). Age changes in small-intestinal mucosa. Lancet 2: 849–50.

    PubMed  CAS  Google Scholar 

  131. Corazza GR, Frazzoni M, Gatto MRA, et al. (1986). Ageing and small bowel mucosa: a morphometric study. Gerontology 32: 60.

    PubMed  CAS  Google Scholar 

  132. Beaumont DM, Cobden I, Sheldon WL, Laker MF, James OF (1987). Passive and active carbohydrate absorption by the ageing gut. Age Aging 16: 294–300.

    CAS  Google Scholar 

  133. Saltzman JR, Kowdley KV, Perone G, et al. (1995). Changes in small intestine permeability with ageing. JAm Geriatr Soc. 43: 160

    CAS  Google Scholar 

  134. Husebye E, Engedal K (1992). The patterns of motility are maintained in the human small intestine throughout the process of ageing. Scand J Gastroenterol. 27: 397–404.

    PubMed  CAS  Google Scholar 

  135. Madsen J (1992). Effects of gender, age, and body mass index on gastrointestinal transit times. Dig Dis Sci. 37: 1548.

    PubMed  CAS  Google Scholar 

  136. Kawanishi H, Kiely J (1989). Immune-related alterations in aged gut-associated lymphoid tissues in mice. Dig Dis Sci. 34: 175–84.

    PubMed  CAS  Google Scholar 

  137. Hoffmann JC, Zeitz M (2002). Small bowel disease in the elderly: diarrhoea and malabsorption. Best Pract Res Clin Gastroenterol. 16: 17–36.

    PubMed  Google Scholar 

  138. Buzby JC, Roberts T (1997). Economic costs and trade impacts of microbial foodborne illness. World Health Stat Q. 50: 57–66.

    PubMed  CAS  Google Scholar 

  139. Nagar A, Roberts IM (1999). Small bowel diseases in the elderly. Clin Geriatr Med. 15: 473–86.

    PubMed  CAS  Google Scholar 

  140. Brasitus TA, Sitrin MD (1990). Intestinal malabsorption syndromes. Ann Rev Med, 41: 339–47.

    PubMed  CAS  Google Scholar 

  141. Montgomery RD, Haeney MR, Ross IN (1978). The ageing gut: a study of intestinal absorption in relation to nutrition in the elderly. Q JMed. 47: 197–224.

    CAS  Google Scholar 

  142. Montgomery RD, Haboubi NY, Mike NH, Chesner IM, Asquith P (1986). Causes of malabsorption in the elderly. Age Ageing 15: 235–40.

    PubMed  CAS  Google Scholar 

  143. Madhok R, MacKenzie JA, Lee FD, Bruckner FE, Terry TR, Sturrock RD (1986). Small bowel ulceration in patients receiving non-steroidal anti-inflammatory drugs for rheumatoid arthritis. Q JMed. 58: 53–8.

    CAS  Google Scholar 

  144. McEvoy A, Dutton J, James OF (1983). Bacterial contamination of the small intestine is an important cause of occult malabsorption in the elderly. Br Med J. 287: 789–93.

    CAS  Google Scholar 

  145. Haboubi NY, Montgomery RD (1992). Small-bowel bacterial overgrowth in elderly people: clinical significance and response to treatment. Age Ageing 21: 13–19.

    PubMed  CAS  Google Scholar 

  146. Freeman H, Lemoyne M, Pare P (2002). Coeliac disease. Best Pract Res Clin Gastroenterol. 16: 37–49.

    PubMed  Google Scholar 

  147. Swinson CM, Levi AJ (1980). Is coeliac disease underdiagnosed? Br Med J. 281: 1258–60.

    PubMed  CAS  Google Scholar 

  148. Kirby J, Fielding JF (1984). Very adult coeliac disease! The need for jejunal biopsy in the middle aged and elderly. Irish Med J. 77: 35–6.

    CAS  Google Scholar 

  149. Freeman HJ (1995a). Celiac associated autoimmune thyroid disease. A study of 16 patients with overt hypothyroidism. Can J Gastroenterol. 9: 242–6.

    Google Scholar 

  150. Freeman HJ (1995b). Clinical spectrum of biopsy-defined celiac disease in the elderly. Can J Gastroenterol. 9: 42–6.

    Google Scholar 

  151. Weinstein WM, Saunders DR, Tytgat GN, Rubin CE (1970). Collagenous sprue — an unrecognized type of malabsorption. NEngl JMed. 283: 1297–301.

    CAS  Google Scholar 

  152. Robert ME, Ament ME, Weinstein WM (2000). The histologic spectrum and clinical outcome of refractory and unclassified sprue. Am J Surg Pathol. 24: 676–87.

    PubMed  CAS  Google Scholar 

  153. Cellier C, Delabesse E, Helmer C, et al. (2000). Refractory sprue, coeliac disease, and enteropathy-associated T-cell lymphoma. French Coeliac Disease Study Group. Lancet 356: 203–8.

    Google Scholar 

  154. Freeman HJ, Weinstein WM, Shnitka TK, Piercey JR, Wensel RH (1977). Primary abdominal lymphoma presenting manifestation of celiac sprue or complicating dermatitis herpetiformis. Am JMed. 63: 585–94.

    CAS  Google Scholar 

  155. Freeman HJ (1996). Neoplastic disorders in 100 patients with celiac disease. Can J Gastroenterol. 10: 163–6.

    Google Scholar 

  156. Meyer D, Stavropolous S, Diamond B, Shane E, Green PHR (2001). Osteoporosis in a North American adult population with celiac disease. Am J Gastroenterol. 96: 112–19.

    PubMed  CAS  Google Scholar 

  157. Valdimarsson T, Lofman O, Toss G (1996). Reversal of osteopenia with diet in adult coeliac disease. Gut 38: 322–7.

    PubMed  CAS  Google Scholar 

  158. MacDonald PH (2002). Ischaemic colitis. Best Pract Res Clin Gastroenterol. 16: 51–61.

    PubMed  CAS  Google Scholar 

  159. Brandt LJ, Boley SJ (1992). Colonic ischemia. Surg Clin NAm. 72: 203–29.

    CAS  Google Scholar 

  160. Bower TC (1993). Ischemic colitis. Surg Clin NAm. 73: 1037–53.

    CAS  Google Scholar 

  161. Guttormson NL, Burrick MP (1998). Mortality from ischemic colitis. Dis Colon Rectum 32: 469–72.

    Google Scholar 

  162. Poeze M, Froon AHM, Greve JWM, Ramsay G (1998). D-Lactase as an early marker of intestinal ischemia after ruptured abdominal aortic aneurysm repair. Br J Surg. 85: 1221–4.

    PubMed  CAS  Google Scholar 

  163. Murray MJ, Gonze MD, Nowak LR, Cobb CF (1994). Serum D-lactase levels as an aid to diagnosing acute intestinal ischemia. Am J Surg. 167: 575–8.

    PubMed  CAS  Google Scholar 

  164. Scowcroft CW, Sanowski RA, Kozarek RA (1981). Colonoscopy in ischemic colitis. Gastrointest Endo. 27: 145–61.

    Google Scholar 

  165. Balthazar EJ, Yen BC, Gordon RB (1999). Ischemic colitis: CT evaluation of 54 cases. Radiology 211: 381–8.

    PubMed  CAS  Google Scholar 

  166. Bharucha AE, Tremaine WJ, Johnson D, Batts KP (1996). Ischemic proctosigmoiditis. Am J Gastroenterol. 91: 2305–9.

    PubMed  CAS  Google Scholar 

  167. Danse EM, Van Beers BE, Jamart J (2000). Prognosis of ischemic colitis: comparison of color Doppler sonography with early clinical and laboratory fndings. Am JRoenterol. 175: 1151–4.

    CAS  Google Scholar 

  168. Teefey SA, Roarke MC, Brink JA (1996). Bowel wall thickening: differentiation of inflammation from ischemia with color Doppler and duplex US. Radioloogy 198: 547–51.

    CAS  Google Scholar 

  169. Wilkerson DK, Mezrick R, Drake C (1990). MR imaging of acute occlusive intestinal ischemia. J Vasc Surg. 11: 567–71.

    PubMed  CAS  Google Scholar 

  170. Moallem AG, Gerard PS, Japanwalla M (1995). Positive in-111 WBC scan in a patients with ischemic ileocolitis and negative colonoscopies. Clin Nucl Med. 20: 483vz–5.

    Google Scholar 

  171. Gandhi SK, Hanson MM, Vernava AM, Kaminski DL, Longo WE (1996). Ischemic colitis. Dis Colon Rectum 39: 88–100.

    PubMed  CAS  Google Scholar 

  172. Longo WE, Ward D, Vernava AM, Kaminski DL (1997). Outcome of patients with total colonic ischemia. Dis Colon Rectum 40: 1448–54.

    PubMed  CAS  Google Scholar 

  173. Abel ME, Russell TR (1983). Ischemic colitis: comparison of surgical and non-operative management. Dis Colon Rectum 26: 113–15.

    PubMed  CAS  Google Scholar 

  174. Capella G, Guillaumes S, Galera MJ, Rius X (1988). Ischemic colitis. Review of 20 cases. Rev Esp Enferm Apar Dig. 74: 32–6.

    PubMed  CAS  Google Scholar 

  175. Drossman Da, Coruzziari IE, Talley NJ, Thompson WG, Whitehead RWE, eds. (2000). Rome 77 — Functional Gastrointestinal Disorders, 2nd edn. McLean, VA: Degnon Associates.

    Google Scholar 

  176. Kay L (1994). Prevalence, incidence and prognosis of gastrointestinal symptoms in a random sample ofan elderly population. Age Ageing 23: 146–9.

    PubMed  CAS  Google Scholar 

  177. Ragnarsson G, Bodemar G (1998). Pain is temporally related to eating but not to defaecation in the irritable bowel syndrome. Eur J Gastroenterol Hepatol. 10: 415–21.

    PubMed  CAS  Google Scholar 

  178. Halar EN, Hammond MC, La Cavae (1987). Sensory perception thresholds measurement. Arch Phys Med Rehab. 68: 499–507.

    CAS  Google Scholar 

  179. Monga AK, Marrero JM, Stanton S (1997). Is there an irritable bladder in the irritable bowel syndrome. Br J Obstet Gynaecol. 104: 1409–12.

    PubMed  CAS  Google Scholar 

  180. Jailwala J, Imperiale TF, Kroenke K (2000). Pharmalogical treatment of the irritable bowel syndrome: a systematic review of randomized, controlled trials. Annu 7ntern Med. 13: 136–47.

    Google Scholar 

  181. Jackson JF, O’Malley PG, Tomkins G (2000). Treatment of functional gastrointestinal disorders with antidepressant medications: a meta-analysis. Am JMed. 108: 65–72.

    CAS  Google Scholar 

  182. Gurudu S, Fiocchi C, Katz JA (2002). Inflammatory bowel disease. Best Pract Res Clin Gastroenterol. 16: 77–90.

    PubMed  Google Scholar 

  183. Langholz E, Munkholm P, Haagen Nelson O (1991). Incidence and prevalence of ulcerative colitis in the Copenhagen County from 1962 to 1987. Scand J Gastroenterol. 26: 1247–55.

    PubMed  CAS  Google Scholar 

  184. Softley A, Myren J, Clamp S (1988). Inflammatory bowel disease in the elderly patient. Scand J Gastroenterol. 23: 27–30.

    Google Scholar 

  185. Sinclair T, Brunt P, Ashley N (1983). Nonspecific proctocolitis in Northeastern Scotland: a community study. Gastroenterology 76: 7–11.

    Google Scholar 

  186. Edwards RC, Truelove SC (1963). The course and prognosis of ulcerative colitis. Gut 4: 299–315.

    PubMed  CAS  Google Scholar 

  187. Gupta S, Saverymuttu SH, Keshavarzian A, Hodgson HJ (1985). Is the pattern of inflammatory bowel disease different in the elderly? Age Ageing 14: 366–70.

    PubMed  CAS  Google Scholar 

  188. Polito J, Childs B, Mellits E (1996). Crohn’s disease: influence of age at diagnosis on site and clinical type of disease. Gastroenterology 111: 580–6.

    PubMed  Google Scholar 

  189. Foxworthy D, Wilson J (1985). Crohn’s disease in the elderly: prolonged delay in diagnosis. JAm Geriatr Soc. 33: 492–5.

    CAS  Google Scholar 

  190. Harper P, McAuliffe T, Beeken W (1986). Crohn’s disease in the elderly: a statistical comparison with younger patients matched for sex duration of disease. Arch Intern Med. 146: 753–5.

    PubMed  CAS  Google Scholar 

  191. Stalnikowicz R, Eliakim R, Diab R (1989). Crohn’s disease in the elderly. J Clin Gastroenterol. 11: 411–15.

    PubMed  CAS  Google Scholar 

  192. Church JM (2000). Functional outcome and quality of life in an elderly patient with an ileal pouch-anal anastomosis: a 10 year follow-up. Aust NZ J Surg. 70: 906–7.

    CAS  Google Scholar 

  193. Thompson WG, Longstreth GF, Drossman DA (1999). Functional bowel disorders and functional abdominal pain. Gut 45: 1143–7.

    Google Scholar 

  194. Muller-Lissner S (2002). General geriatrics and gastroenterology: constipation and faecal incontinence. Best Pract Res Clin Gastroenterol. 16: 115–33.

    PubMed  Google Scholar 

  195. Everhart JE, Go VLW, Johannes RS (1989). A longitudinal survey of self-reported bowel habits in the United States. Dig Dis Sci. 34: 1153–62.

    PubMed  CAS  Google Scholar 

  196. Thomas TM, Egan M, Walgrove A, Meade TW (1984). The prevalence of fecal and double incontinence. Comm Med. 6: 216–20.

    CAS  Google Scholar 

  197. Sonnenberg A (1989). Epidemiologie der analen Inkontinenz. In: Muller-Lissner SA, Akkermans LMA, eds. Chronische Obstipation und Stuhlinkontinenz. Berlin Heidelberg, New York: Springer, pp. 157–62.

    Google Scholar 

  198. McHugh SM, Diamant NE (1987). Effect of age, gender and parity on anal canal pressures. Dig Dis Sci. 32: 726–36.

    PubMed  CAS  Google Scholar 

  199. Parks TG (1975). Natural history of diverticular disease of the colon. Clin Gastroenterol. 4: 53–69.

    PubMed  CAS  Google Scholar 

  200. Thompson WG (1968). Do colonic diverticula cause symptoms? Am JGastroenterol. 81: 613.

    Google Scholar 

  201. Young-Fadok TM, Roberts PL, Spencer MP, Wolff BG (2000). Colonic diverticular disease. Curr Prob Surg. 37: 457–514.

    CAS  Google Scholar 

  202. Forde KA (1981). Colonoscopy in acute rectal bleeding. Gastrointest Endo. 27: 219–20.

    CAS  Google Scholar 

  203. Rege RV, Nahrwald DL (1989). Diverticular disease. Curr Prob Surg. 26: 138–89.

    Google Scholar 

  204. Popper H (1986). Aging and the liver. Prog Liver Dis. 8: 659–83.

    PubMed  CAS  Google Scholar 

  205. Martin SP, Ulrich CD II (1999). Pancreatic disease in the elderly. Clin Geriatr Med. 15: 579–605.

    PubMed  CAS  Google Scholar 

  206. Williams D, Woodhouse K (1996). Age-related changes in O-deethylase and aldrin epoxidase activity in mouse skin ad liver mirosomes. Age Ageing 25: 377–80.

    PubMed  CAS  Google Scholar 

  207. Altman DF (1990). Changes in gastrointestinal, pancreatic, biliary, and hepatic function with aging. Gastroenterol Clin NAm. 19: 227–34.

    CAS  Google Scholar 

  208. Wynne HA, Cope LH, Herd B (1990). The association of age and frailty with paracetamol conjugation I man. Age Ageing 19: 419–24.

    PubMed  CAS  Google Scholar 

  209. Jansen PLM (2002). Liver disease in the elderly. Best Pract Res Clin Gastroenterol. 16: 149–58.

    PubMed  Google Scholar 

  210. Chien NT, Dundoo G, Horani MH (1999). Seroprevalence of viral hepatitis in an older nursing home population. JAm Geriatr Soc. 47: 1110–3.

    CAS  Google Scholar 

  211. Harris DR, Gonin R, Alter HJ (2001). The relationship of acute transfusion-associated hepatitis to the development of cirrhosis in the presence of alcohol abuse. Annu Intern Med. 134: 120–4.

    CAS  Google Scholar 

  212. Zetterman RK, Belle SH, Hoofnagle (1998). Age and liver transplantation: a report of the liver transplantation database. Transplantation 66: 500–6.

    CAS  Google Scholar 

  213. Collins BH, Pirsch JD, Becker YT (2000). Long-term results of liver transplantation in older patients 60 years of age and older. Transplantation 70: 780–3.

    PubMed  CAS  Google Scholar 

  214. Go VLW (1994). Etiology and epidemiology of pancreatitis in the United States. In: Bradley EL, ed. Acute Pancreatitis: Diagnosis and Therapy. New York: Raven Press, pp. 235–41.

    Google Scholar 

  215. Scholhamer CF Jr, Spiro HM (1979). The first attack of acute pancreatitis: a clinical study. JClin Gastroenterol. 1: 325–9.

    Google Scholar 

  216. Park J, Fromkes J, Cooperman M (1986). Acute pancreatitis in elderly patients. Am J Surg. 152: 638–42.

    PubMed  CAS  Google Scholar 

  217. Nagai H, Ohtsubo K (1984). Pancreatic lithiasis in the aged. Gastroenterology 86: 331–8.

    PubMed  CAS  Google Scholar 

  218. Fernandez-del Castillo C, Harringer W, Warshaw AL (1991). Risk factors for pancreatic cellular injury after cardiopulmonary bypass. NEngl JMed. 325: 382–7.

    CAS  Google Scholar 

  219. Mutinga M, Rosenbluth A, Tenner SM (2000). Does mortality occur early or late in acute pancreatitis? Int JPancreatol. 28: 91–5.

    CAS  Google Scholar 

  220. Lowham A, Lavelle J, Leese T (1999). Mortality from acute pancreatitis. Late septic deaths can be avoided but some early deaths still occur. Int JPancreatol. 25: 103–6.

    Google Scholar 

  221. Clain JE, Pearson RK (1999). Diagnosis of chronic pancreatitis. Is a gold standard necessary? Surg Clin NAm. 79: 829–45.

    CAS  Google Scholar 

  222. Schmitz-Moormann P, Himmelmann GW, Brandes JW (1985). Comparative radiological and morphological study of human pancreas. Pancreatitis like changes in postmortem ductograms and their morphological pattern. Possible implication for ERCP. Gut 26: 406–14.

    Google Scholar 

  223. Niederhuber JE, Brennan MF, Menck HR (1995). The National Cancer Data Base report on pancreatic cancer. Cancer 76: 1671–7.

    PubMed  CAS  Google Scholar 

  224. Hodul P, Tansey J, Golts E (2001). Age is not a contraindication to pancreaticoduodenectomy. Am Surg. 67: 270–5.

    PubMed  CAS  Google Scholar 

  225. Sohn TA, Yeo CJ, Cameron (1998). Should pancreaticoduodenetomy be performed in octogenarians? JGastrointestal Surg. 2: 207–16.

    CAS  Google Scholar 

  226. Gloor B, Ahmed Z, Uhl W, Buchler MW (2002). Pancreatic disease in the elderly. Best Pract Res Clin Gastroenterol. 16: 159–70.

    PubMed  Google Scholar 

  227. Balcombe NR,Sinclair A(2001). Ageing: definitions, mechanisms and the magnitude of the problem. Best Pract ResClin gastroenterrol. 15: 835–49.

    Google Scholar 

  228. Becker GH, Meyer J, Necheles H (1950). Fat absorption in young and old age. Gastroenterology 14: 80–90.

    PubMed  CAS  Google Scholar 

  229. Bennett G, Talley NJ (2002). Irritable bowel syndrome in the elderly. Best Pract Res Clin Gastroenterol. 16: 63–76.

    PubMed  Google Scholar 

  230. Borum ML (1999). Peptic ulcer disease in the elderly. Clin Geriatr Med. 15: 457–71.

    PubMed  CAS  Google Scholar 

  231. Cappell MS (1998). Intestinal (mesenteric) vasculopathy II. Ischemic colitis and chronic mesenteric ischemia. Gastroenterol Clin NAm. 27: 827–60.

    CAS  Google Scholar 

  232. Cellier C, Delabesse E, Helmer J (1984). Refractory sprue, coeliac disease, and enteropathyassociated T-cell lymphoma. Lancet 356: 203–8.

    Google Scholar 

  233. Cullen DJ, Hawkey GM, Greenwood DC (1997). Peptic ulcer bleeding in the elderly: relative roles of Helicobacter pylori and non-steroidal anti-inflammatory drugs. Gut 41: 459–62.

    PubMed  CAS  Google Scholar 

  234. Garry PJ, Goodwin JS, Hunt WC, Hooper EM, Leonard AG (1982). Nutritional status in a healthy elderly population: dietary and supplemental intakes. JAm Coll Nutr. 36: 319–31.

    CAS  Google Scholar 

  235. Gupta S, Savermuttu S, Keshavarzian A (1985). Is the pattern of inflammatory bowel disease different in the elderly? Age Ageing 14: 366–70.

    PubMed  CAS  Google Scholar 

  236. Kassarjian Z, Russell RM (1989). Hupochlorhydria: a factor in nutrition. Annu Rev Nutr. 9: 271–85.

    PubMed  CAS  Google Scholar 

  237. Kern M, Bardan E, Arndorfer R (1999). Comparison of upper esophageal sphincter opening in healthy asymptomatic young and elderly volunteers. Ann Otol Rhinol Laryngol. 108: 982–9.

    PubMed  CAS  Google Scholar 

  238. Khaghan N, Holt PR (2002). Peptic disease in elderly patients. Can J Gastroenterol. 14: 922–8.

    Google Scholar 

  239. Kinyamu HK, Gallagher JC, Balhorn KE, Petranick KM, Rafferty KA (1997). Serum vitamin D metabolites and calcium absorption in normal young an elderly free-living women and in women living in nursing homes. Am J Clin Nutr. 65: 790–7.

    PubMed  CAS  Google Scholar 

  240. Longo WE, Ballantyne GH, Gusberg RJ (1992). Ischemic colitis: patterns and prognosis. Dis Colon Rectum 35: 726–30.

    PubMed  CAS  Google Scholar 

  241. Pilotto A (2001) Helicobacter pylori-associated peptic ulcer disease in older patients: current management strategies. Drugs Aging 18: 487–94.

    PubMed  CAS  Google Scholar 

  242. Place RJ, Simmang CL (2002). Diverticular disease. Best Pract Res Clin Gastroenterol. 16: 135–48.

    PubMed  Google Scholar 

  243. Schlemper RJ, Riddell RH, Kato Y (2000). The Vienna classification of gastrointestinal epithelial neoplasma. Gut 47: 251–5.

    PubMed  CAS  Google Scholar 

  244. Scholhamer CF Jr, Spiro HM (1979). The first attack of acute pancreatitis: a clinical study. J Clin Gastroenterol. 1: 325–9.

    PubMed  Google Scholar 

  245. Tierney AJ (1996). Undernutrition and elderly hospital patients: a review. JAdv Nurs. 23: 228–46.

    CAS  Google Scholar 

  246. Vetta F, ronzoni S, Tagliere G, Bollea MR (1999). The impact of malnutrition on the quality of life in the elderly. Clin Nutr. 18: 259–67.

    PubMed  CAS  Google Scholar 

  247. Volkery D (1996). Ernahrungsprobleme in der Geriatrie Mangelernahrung bei geriatrischen patienten. Aktuelle Ernahrungsmedizin 21: 200–2.

    Google Scholar 

  248. Waye JD, Kahn O, Auerbach M (1996). Complications of colonoscopy and flexible sigmoidoscopy. Gastrointest Endosc Clin NAm. 6: 343–77.

    CAS  Google Scholar 

  249. Weinstein WM, Saunders DR, Tytgat GN (1970). Collagenous sprue-an unrecognized type of malabsorption. NEngl JMed. 283: 1297–301.

    CAS  Google Scholar 

  250. Wynne HA, Yelland C, Cope LH (1993). The association of age and frailty with the pharmacokinetics and pharmacodynamics of metoclopramide. Age Ageing 22: 354–9.

    PubMed  CAS  Google Scholar 

  251. Zoli M, Magalotti D, Bianchi G (1999). Total and functional hepatic blood flow decrease in parallel with ageing. Age Ageing 28: 29–33.

    Google Scholar 

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    L. Drozdowski, M. Keelan, M. T. Clandinin & A. B. R. Thomson

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Drozdowski, L., Keelan, M., Clandinin, M.T., Thomson, A.B.R. (2003). Aging of the Gastrointestinal System. In: Aspinall, R. (eds) Aging of the Organs and Systems. Biology of Aging and Its Modulation, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0673-5_7

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