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The Aging Male Reproductive System

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Aging of the Organs and Systems

Part of the book series: Biology of Aging and Its Modulation ((BIMO,volume 3))

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Abstract

The reproductive glands are an essential part of the human body. Extensive changes occur as we develop in the womb, to the period of puberty, and then as we age. Through out this time, intricate and timely hormonal changes occur in a unique manner that allow these changes to occur. As the process unwinds our aging body reflects the decades of repetitive assimilation and protection of the germ lines, as well as hormonal decline that affects every male. The revolution of science has allowed us to better understand the aging process so that maintenance of well being and functionality can be preserved. Hopefully, better understanding of this process will allow us to promote successful aging.

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References

  1. Vermulen A (1991). Androgens in the aging male. JClin Endocrinol Metab. 73: 221.

    Article  Google Scholar 

  2. Bhasin S (1992). Clinical review 34: androgen treatment of hypogonadal men. J Clin Endocrinol Metab. 74: 1221.

    Article  PubMed  CAS  Google Scholar 

  3. Pirk KM, Doerr P (1970). Age related changes in free plasma testosterone, dihydrotestosterone and oestradiol. Acta Endocrinol. 80: 171.

    Google Scholar 

  4. Gray A, Feldman HA, Mckinlay JB, et al. (1991). Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts male aging study. J Clin Endocrinol Metab. 73: 1016.

    Article  PubMed  CAS  Google Scholar 

  5. Mitchell S, Harman E, Metter J, Tobin J, Pearson J, Blackman M (2001). Longitudinal effects of aging on serum total and free tesosterone levels in healthy men. J Clin Endocrinol Metab. 86 (2): 724.

    Article  Google Scholar 

  6. Wishar JM, Need AG, Horowitz M, Morris HA, Nordin BE (1995). Effect of age on bone density and bone turnover in men. Clin Endocrinol. 42: 141–46.

    Article  Google Scholar 

  7. Vermeulen A, Deslypere JP (1985). Testicular endocrine function in the ageing male. Maturitas 7: 273–9.

    Article  PubMed  CAS  Google Scholar 

  8. Morley JE, Charlton E, Patrick P, et al. (1998). Validation ofa screening questionnaire for androgen deficiency in aging males. Endocrine Society Abstracts.

    Google Scholar 

  9. Lafferty FW, Spencer GE, Pearson OH (1964). Effects of androgens,estrogens and high calcium intakes on bone formation and resorption in osteoporosis. Am J Med. 36: 514.

    Article  PubMed  CAS  Google Scholar 

  10. Baker HWG (1998). Reproductive effects of nontesticular illness. Endocrinol Metab Clin N Am. 27: 831–50.

    Article  CAS  Google Scholar 

  11. Handelsman DJ (1994). Testicular dysfunction in systemic disease. Endocrinol Metab Clin NAm. 23: 839–56.

    CAS  Google Scholar 

  12. Morley JE, Melmed S (1979). Gonadal dysfunction in systemic disorders. Metabolism 28: 1051–73.

    Article  PubMed  CAS  Google Scholar 

  13. Gray A, Feldman HA, Mckinlay JB, et al. (1991). Age disease, and changing sex hormone levels in middle-aged men: results of the Massachusets Male aging Study. J Clin Endocrinol Metab. 3: 1016–25.

    Article  Google Scholar 

  14. Haji M, Tanaka S, Nishi Y, et al. (1994). Sertoli cell function declines earlier than Leydig cell function in aging Japanese men. Maturitas 18: 143–53.

    Article  PubMed  CAS  Google Scholar 

  15. Kaiser FE, Vviosca SP, Morley JE, et al. (1988). Impotence and aging: clinical and hormonal factors. J Am Geriatric Soc. 36: 511–19.

    CAS  Google Scholar 

  16. Korenman SG, Morley JE, Mooradian AD, et al. (1990). Secondary hypogonadism in older men. Its relation to impotence. J Clin Endocrinol Metab. 71: 963–9.

    Article  PubMed  CAS  Google Scholar 

  17. Nankin HR, Calkins JH (1986). Decreased bioavailable testosterone in aging normal and impotent men. J Clin Endocrinol Metab. 63: 1418–20.

    Article  PubMed  CAS  Google Scholar 

  18. Orrell RW, Woodrow DF, Barrett MC, et al. (1995). Testosterone deficiency myopathy. J Royal Soc Med. 88: 454–6.

    CAS  Google Scholar 

  19. Bremmer WJ, Vitiello MV, Prinz PN (1983). Loss of circadian rhythmicity in blood testosterone levels with aging in normal men. J Clin Endocrinol Metab. 56: 1278.

    Article  Google Scholar 

  20. Plymate Sr, Tenover JS, Bremner WJ (1989). Circadian variation in testosterone, sex hormone-binding globulin, and calculated non-sex hormone-binding globulin bound testosterone in healthy and elderly men. J Androl. 10: 366.

    Google Scholar 

  21. Werner AA (1946). The male climacteric: report of two hundred and seventy-three cases. J Am Med Assoc. 126: 472–7.

    Google Scholar 

  22. Morley JE, Charlton E, Patrick P, et al. (1998). Validation ofa screening questionnaire for androgen deficiency in aging males. Endocrine Society Abstracts.

    Google Scholar 

  23. Morley JE, Patrick P, Perry HM (2002). Evaluation of assays available to measure free testosterone. Metabolism 51: 554–9.

    Article  PubMed  CAS  Google Scholar 

  24. Vermeulen A, Verdonck L, Kaufman JM (1999). A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab. 84: 3666–72.

    Article  PubMed  CAS  Google Scholar 

  25. Morely JE, Kaiser FE (1989). Sexual function with advancing age. Med Clin NAm. 73: 1483–95.

    Google Scholar 

  26. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB (1994). Impotence and its medical and psychosocial correlates: results of the Massachusetts male aging study. J Urol. 151: 54–61.

    PubMed  CAS  Google Scholar 

  27. Haji M, Tanaka S, Nishi Y, et al. (1994). Sertoli cell function declines earlier than Leydig cell function in aging Japanese men. Maturitas 18: 143–53.

    Article  PubMed  CAS  Google Scholar 

  28. Neaves WB, Johnson L, Porter JC, Parker CR Jr, Petty CS (1984). Leydig cell numbers, daily sperm production, and serum gonadotropin levels in aging men. J Clin Endocrinol Metab. 59: 756–63.

    Article  PubMed  CAS  Google Scholar 

  29. Kaler LW, Neaves WB (1978). Attrition of the human Leydig cell population with advancing age. Anat Rec. 192: 513–18.

    Article  PubMed  CAS  Google Scholar 

  30. Morley JE, Kaiser FE (1993). Impotence: the internist’s approach to diagnosis and treatment. Adv Intern Med. 38: 151–68.

    PubMed  CAS  Google Scholar 

  31. Neaves WWB, Jhonson L, Porter JC, Parker CR Jr, Petty CS (1984). Leydig cell numbers, daily sperm production, and serum gonadotropin levels in aging men. J Clin Endocrinol Metab. 59: 756–63.

    Article  PubMed  CAS  Google Scholar 

  32. Jhonson L, Grumbles JS, Bagheri A, Petty CS (1990). Increased germ cell degeneration during postprophase of meiosis is related to increased serum follicle-stimulating hormone concentrations and reduced daily sperm production in aged men. Biol Reprod. 42: 281–7.

    Article  Google Scholar 

  33. Neaves WB, Johnson L, Petty CS (1987). Seminiferous tubules and daily sperm production in older adult men with varied numbers of Leydig cells. Biol Reprod. 36: 301–8.

    Article  PubMed  CAS  Google Scholar 

  34. Neischlag E, Lammers U, Freischem CW, Langer K, Wickings EJ (1982). Reproductive functions in young fathers and grandfathers. J Clin Endocrinol Metab. 55: 676–81.

    Article  Google Scholar 

  35. Schwartz D, Mayaux MJ, Spira A, et al. (1983) Semen characteristics as a function of age in 833 fertile men. Tertil Steril. 39: 530–5.

    CAS  Google Scholar 

  36. Rolf C, Behre HM, Nieschlag E (1996). Reproductive parameters ofolder compared to younger men in infertile couples. Int JAndrol. 19: 135–42.

    Article  CAS  Google Scholar 

  37. Silber SJ (1991). Effects of age on male fertility. Semin Reprod Endocrinol. 9: 241–8.

    Article  Google Scholar 

  38. Plas E, Berger P, Hermann M, Pfluger H (2000). Effects of aging on male fertility? Exp Gerontol. 35: 543–51.

    Article  PubMed  CAS  Google Scholar 

  39. Rolf C. Nieschlag E (2001). Reproductive functions, fertility and genetic risks of aging men. Exp Clin Endocrinol Diabetes 109: 68–74.

    Google Scholar 

  40. Grey A, Berlin JA, Mckinlay JB, Longcope C (1999). An examination of research design effects on the association of testosterone and male aging: results ofa meta-analysis. J Clin Epidemiol. 44: 671–84.

    Article  Google Scholar 

  41. Rubens R, Dhont M, Vermeulen A (1974). Further studies on Leydig cell function in old age. J Clin Endocrinol Metab. 39: 40.

    Article  PubMed  CAS  Google Scholar 

  42. Harman SM, Tsitouras PD (1980). Reproductive hormones in aging men. I. Measurement of sec steroids, basal leuteinizing hormone, and Leydig cell response to human chorionic gonadotropin. JClin Endocrinol Metab. 51: 35.

    Article  CAS  Google Scholar 

  43. Longscope E (1973). The effect of human chorionic gonadotropin on plasma steroid levels in young and old men. Steroids 21: 583.

    Article  Google Scholar 

  44. Hammar M (1985). Impaired in vitro testicular endocrine function in elderly men. Andrologia 17: 444.

    Article  PubMed  CAS  Google Scholar 

  45. Vermeulen A, Reubens R, Verdonck L (1972). Testosterone secretion and metabolism in male senescence. J Clin Endocrinol Metab. 34: 730–5.

    Article  PubMed  CAS  Google Scholar 

  46. Morely JE, Perry HM (2000). Androgen deficiency in aging men: role of testosterone replacement therapy. J Lab Clin Med. 135: 370–8.

    Article  Google Scholar 

  47. Winters SJ, Sherins RRJ, Troen P (1984). The gonadotropin-suppressive activity of androgen is increased in elderly men. Metabolsim 33: 1052–9.

    Article  CAS  Google Scholar 

  48. Veldhuis JD, Urban RJ, Lizarralde G, et al. (1992). Attenuation of leuteinizing hormone secretory burst amplitude as a proximate basis for the hypoandrogenism of health aging men. J Clin Endocrinol Metab. 75: 707–13.

    Article  PubMed  CAS  Google Scholar 

  49. Morley JE, Baranetsky NG, Wingert TD, et al. (1980). Endocrine effects of naloxoneinduced opiate receptor blockade. J Clin Endocrinol Metab. 50: 251–7.

    Article  PubMed  CAS  Google Scholar 

  50. Billngton CJ, Shafer RB, Morley JE (1990). Effects of opioid blockade with nalmefene in older impotent men. Life Sci. 47: 799–805.

    Article  Google Scholar 

  51. Mikuma N, Kumamoto AM, Maruta H, et al. (1994) Role of the hypothalamic opioidergic system in the control of gonadotropin secretion in elderly men. Andrologia 26: 39–45.

    Article  PubMed  CAS  Google Scholar 

  52. Tenover JS, Matsumoto AM, Plymate SR, et al. (1987). The effects of aging in normal men on bioavailable testosterone and leuteinizing hormone secretion: response to clomiphene citrate. J Clin Endocrinol Metab. 65: 1118–26.

    Article  PubMed  CAS  Google Scholar 

  53. Lona P, Petraglia F, Concari M, et al. (1998). Influence of age and sex on serum hormone secretion concentrations of total dimeric activin A. Eur J Endocrinol. 139: 487–92.

    Article  Google Scholar 

  54. Krithivas K, Yurgalevitch SM, Mohr BA, et al. (1999). Evidence that the CAG repeat in the androgen receptor gene is associated with the age realted decline in serum androgen levels in men. J Endocrinol. 162: 137–42.

    Article  PubMed  CAS  Google Scholar 

  55. Beilin J, Ball EEM, Favaloro JM, Zajac JD (2000). Effect of the androgen receptor CAG repeat polymorphism on transcriptiona; activity: specificity in prostate and non-prostate cell lines. J Mol Endocrinol. 25: 85–6.

    Article  PubMed  CAS  Google Scholar 

  56. Davidson JM, Camargo Ca, Smith ER (1979). Effects of androgen on sexual behavior in hypogonadal men. J Clin Endocrinol Metab. 48: 955–8.

    Article  PubMed  CAS  Google Scholar 

  57. Schiavi RC, Schreiner-Engel P, White D, et al. (1991). The relationship between pituitary-gonadal function and sexual behavior in healthy aging men. Psychosom Med 53: 363–74.

    PubMed  CAS  Google Scholar 

  58. Morales A, Jhonston B, Heaton JP, Lundie M (1997). Testosterone supplementation for hypogonadal impotence: assesment of biochemical measures and therapeutic outcomes. J Urol. 157: 849–54.

    Article  PubMed  CAS  Google Scholar 

  59. Hajjar RR, Kaiser FE, Morely JE. Outcomes of long-term testosterone replacement in older hypogonadal males: a retrospective analysis. J Clin Endocrinol Metab. 82: 3793–6.

    Google Scholar 

  60. Bhasin S, Storer TW, Berman N, et al. (1996). The effects of supraphysiologic doses of testosterone on muscle mass and strength in normal men. N Engl J Med. 335: 1–7.

    Article  PubMed  CAS  Google Scholar 

  61. Brodsky IG, Balangopal P, Nair KS (1996). Effects of testosterone replacement on muscle mass and muscle protein synthesis in hypogonadal men: a clinical research center study. J Clin Endocrinol Metab. 81: 3469–75.

    Article  PubMed  CAS  Google Scholar 

  62. Urban RJ, Bodenburg YH, Gilikson C, et al. (1995). Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis. Am J Physio l269: E820–6.

    CAS  Google Scholar 

  63. Frischknecht R (1998). Effect of training on muscle strength and motor function in the elderly. Reprod Nutr Dev. 38: 167–74.

    Article  PubMed  CAS  Google Scholar 

  64. Orrell RW, Woodrow DF, Barrett MC, et al. (1995). Testosterone deficiency myopathy. J Royal Soc Med 88: 454–6.

    CAS  Google Scholar 

  65. Sih R, Morley JE, Kaiser FE et al. (1997). Testosterone replacement in older hypogonadal men: a 12 month randomized controlled trial. J Clin Endocrinol Metab. 82: 1661–7.

    Article  PubMed  CAS  Google Scholar 

  66. Morely JE, Perry HM III, Kaiser FE, et al. (1993). Effects of testosterone replacement in older hypogonadal men: a preliminary study. J Am Geriatric Soc. 41: 149–52.

    Google Scholar 

  67. Urban RJ, Bodenburg Yh, Gilikson C et al. (1995). Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis. Am J Physiol. 269: E820–6.

    PubMed  CAS  Google Scholar 

  68. Morley JE, Kaiser FE, Raum Wj, et al. (1997). Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormone. Proc Natl Acad Sci USA 94: 7537–42.

    Article  PubMed  CAS  Google Scholar 

  69. Tenover JS (1998). Testosterone replacement therapy: a step closer. World Congress on Aging - Male. Geneva, abstract P2.

    Google Scholar 

  70. Hajjar RR, Kaiser FE, Morley JE (1997). Outcomes of long-term Testosterone replacement in older hypogonadal males: a retrospective analysis. J Clin Endocrinol Metab. 82: 3793–6.

    Article  PubMed  CAS  Google Scholar 

  71. Rosano GM, Leonardo F, Pagnotta P, et al. (1999). Acute anti-ischemic effect of testosterone in men with coronary artery disease. Circulation 99: 1666–70.

    Article  PubMed  CAS  Google Scholar 

  72. Schweiger U, Deuschle M, Weber B, etal. (1999). Testosterone, gonadotropin, and cortisol secretion in male patients with major depression. Psychosom Med. 61: 292–6.

    CAS  Google Scholar 

  73. Seidman SN, Rabkin JG (1998). Testosterone replacement therapy for hypogonadal men with SSRI-refractory depression. J Affect Disord. 48: 157–61.

    Article  PubMed  CAS  Google Scholar 

  74. Barrett-Connor E, von Muhlen DG, Krotz-Silverstein D (1999). Bioavailable testosterone and depressed mood in older men: the Rancho Bernardo study. J Clin Endocrinol Metab. 84: 573–7.

    Article  PubMed  CAS  Google Scholar 

  75. Bhasin S, Swerdloff RS, Steineer B, et al. (1992). A biodegradable testosterone micro-capsule formulation provides uniform eugonadal levels of testosterone for 10–11 weeks in hypogonadal men. J Clin Endocrinol Metab. 74: 75–83.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Geriatric Medicine and St. Louis VA Medical Center, GRECC, Saint Louis University Health Sciences Center, St. Louis, Missouri, USA

    Rafi T. Kevorkian & John E. Morley

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  1. Rafi T. Kevorkian
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  2. John E. Morley
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Editors and Affiliations

  1. Department of Immunology, Imperial College of Science Technology and Medicine, Chelsea and Westminster Hospital, London, UK

    Richard Aspinall

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Kevorkian, R.T., Morley, J.E. (2003). The Aging Male Reproductive System. In: Aspinall, R. (eds) Aging of the Organs and Systems. Biology of Aging and Its Modulation, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0673-5_13

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  • DOI: https://doi.org/10.1007/978-94-017-0673-5_13

  • Publisher Name: Springer, Dordrecht

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