Abstract
In scale-up as well as in carpentry, there is no single preferred tool to solve your problems. You need a whole tool box and you generally need more than one tool in order to do one particular scale-up job properly. After a general introduction about scale-up I will show you this tool box, a collection of the various methods that can be used to solve scale-up problems. Each of these methods has its advantages and disadvantages. They are arranged in a sequence going from very fundamental to trial and error. Apart from the tools you need a proper state of mind. My suggestion for the preferred state of mind is “scaling-down”. This means that you work backwards, starting with your “minds eye” of the full scale. This is of great help to increase the efficiency of the scale-up job. I will show you a few examples that give some feeling for the fitness for use of the tools for different kinds of jobs. You will also find some introductory references to the literature.
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© 1994 Springer Science+Business Media Dordrecht
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Kossen, N.W.F. (1994). Scale-up. In: Galindo, E., Ramírez, O.T. (eds) Advances in Bioprocess Engineering. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-0641-4_8
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DOI: https://doi.org/10.1007/978-94-017-0641-4_8
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