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Stratospheric ozone depletion, UV exposure and skin cancer: a scenario analysis

  • Harry Slaper
  • Frank R. de Gruijl
Part of the Cancer Prevention — Cancer Causes book series (CPCC, volume 3)

Abstract

There is overwhelming evidence, discussed elsewhere in this book, that exposure of the skin to UV-radiation can lead to, or at least contribute to, the development of skin cancer. The sun is the major source of UV-radiation to which the human skin is exposed. Within the earth’s atmosphere, ozone serves as a partly protective shield by absorbing most of the effective part of the UV-spectrum and thus preventing a major part of the harmful UV from reaching the earth’s surface. Depletion of atmospheric ozone has been observed over large parts of the globe in recent decades, and it was predicted that harmful UV-radiation levels at the earth’s surface would have increased. The observed decrease in ozone was thought to be related to the large-scale emissions of halocarbon compounds as a result of human activity [1]. In 1985, in view of the scientific evidence that the emission of halocarbon compounds could lead to ozone depletion, the United Nations Environment Programme (UNEP) initiated the Vienna Convention to protect the ozone layer. This provided the framework for the discussion and implementation of international restrictions on the production of ozone depleting substances and led to the first international agreement on the reduction of the production of ozone depleting substances in 1987 in the Montreal Protocol. Following scientific evidence that ozone depletion was actually occurring, the Montreal Protocol was strengthened in several later Amendments.

Key words

ozone depletion UV-radiation skin cancer risk assessment Vienna Convention to protect the ozone layer 

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References

  1. 1.
    World Meteorological Organization (1998) Scientific assessment of ozone depletion. Global Ozone and Monitoring Project, Report No 44. WMO.Google Scholar
  2. 2.
    Slaper H, Velders GJM, Daniel JS, de Gruijl FR, van der Leun JC (1996) Estimates of ozone depletion and skin cancer incidence to estimate the Vienna Convention achievements. Nature 384: 256–258.PubMedCrossRefGoogle Scholar
  3. 3.
    United Nations Environment Programme (1998) Environmental Effects of Ozone Depletion: 1998 Assessment. ISBN 92–807–1724–3.Google Scholar
  4. 4.
    CIAP (1975) CIAP Monograph series, Vols. 1–6, Grobecker AJ (Ed. in chf), Washington DC: Climate Impact Assessment Program, Department of TransportationGoogle Scholar
  5. 5.
    Molina MJ, Rowland FS (1974) Stratospheric sink for chlorofluromethanes: chlorine atom catalyzed destruction of ozone. Nature 249: 810–812.CrossRefGoogle Scholar
  6. 6.
    Farman JC, Gardiner BG, Shanklin JD (1985) Large losses of total ozone in Antarctica reveal seasonal ClOx/Nox interaction. Nature 315: 207–210.CrossRefGoogle Scholar
  7. 7.
    European Commission (2001) European research in the stratosphere 1996–2000, advances in our understanding of the ozone layer during THESEO, EUR 19867, ISBN 92–894–1398–0, Luxembourg.Google Scholar
  8. 8.
    Kelfkens G, Bregman A, de Gruijl FR et al. (2002) Ozone Layer – climate change interactions: Influence on UV levels and UV related effects. Dutch National Research Program on Global Air Pollution and Climate Change, OCCUR–project (950303), Report 410–200–112, ISBN 90–5851–079–4, RIVM, Bilthoven.Google Scholar
  9. 9.
    Bais AF, Gardiner BG, Slaper H, et al. (2001) SUSPEN intercomparison of ultraviolet spectroradiometers. J Geophys Res 106 (D12): 12, 509–12, 526.Google Scholar
  10. 10.
    Kjeldstad B, Johnsen B, Koskela T, eds. (1997) The NORDIC intercomparison of ultraviolet and total ozone instruments at Izana. October 1996, Final Report, Meteorological Publications 36, Helsinki: FMI, ISBN 951–697–475–9.Google Scholar
  11. 11.
    De Gruijl FR, Sterenborg HJCM, Forbes PD, et al. (1993) Wavelength dependence of skin cancer induction by ultraviolet irradiation of albino hairless mice. Cancer Res 53: 53–60.PubMedGoogle Scholar
  12. 12.
    De Gruijl FR, Van der Leun JC (1994) Estimate of the wavelength dependency of ultraviolet carcinogenesis in humans and its relevance to the risk assessment of a stratospheric ozone depletion. Health Phys. 67: 314–325.Google Scholar
  13. 13.
    Slaper H, Matthijsen J, den Outer PN, Velders GJM (2001) Climatology of ultraviolet budgets using earth observation (CUBEO): mapping UV from the perspective of risk assessments. Netherlands Remote Sensing Board (BCRS)_USP–2 report 00–17, ISBN 90–54–11–32–6.Google Scholar
  14. 14.
    Kelfkens G, den Outer PN, Slaper H (2001) Risks and ultraviolet budgets using earth observation (RUBEO): including a non–standard atmosphere and geographic ozone trend differences in risk assessments. Netherlands Remote Sensing Board (BCRS)_USP–2 report 01–33, ISBN 90–54–11–378–2.Google Scholar
  15. 15.
    Slaper H, Velders GJM, Matthijsen J (1998) Ozone depletion and skin cancer incidence: a source risk approach. J Hazardous Mat 61: 77–84.CrossRefGoogle Scholar
  16. 16.
    Miller D, Weinstock MA (1994) Nonmelanoma skin cancer in the United States: incidence. J Am Acad Dermatol 30: 774–778.PubMedCrossRefGoogle Scholar
  17. 17.
    Kricker A, Armstrong BK, English DR, Heenan PJ (1995) Does intermittent sun exposure cause basal cell carcinoma? A case-control study in Western Australia. Int J Cancer 60: 489–494.PubMedCrossRefGoogle Scholar
  18. 18.
    Holman CD, Armstrong BK (1984) Cutaneous malignant melanoma and indicators of total accumulated exposure to the sun: an analysis separating histogenetic types. J Natl Cancer Inst 73: 75–82.PubMedGoogle Scholar
  19. 19.
    Green A, Williams G, Neale R, et al. (1999) Daily sunscreen application and beta-carotene supplementation in prevention of basal cell and squamous cell carcinomas of the skin: A randomized controlled trial. Lancet 354: 723–729.PubMedCrossRefGoogle Scholar
  20. 20.
    Gallagher RP, McLean DI, Yang GP, Coldman AJ, Silver HK, Spinelli JJ (1990) Suntan, sunburn and pigmentation factors and the frequency of acquired nevi in children. Similarities to melanoma: the Vancouver Mole Study. Arch Dermatol 126: 770–776.PubMedCrossRefGoogle Scholar
  21. 21.
    Longstreth JD, De Gruijl FR, Kripke ML, Takizawa Y, Van der Leun JC (1995) Effects of increased solar ultraviolet radiation on human health. Ambio 24: 153–165.Google Scholar
  22. 22.
    Scotto J, Fears TR (1987) The association of solar ultraviolet and skin melanoma incidence among Caucasians in the Unites States. Cancer Invest 5: 275–283.PubMedGoogle Scholar
  23. 23.
    Daniel JS, Solomon S, Albritton DL (1995) On the evaluation of halocarbon radiative forcing and global warming potentials. J Geophys Res 100: 1271–1285.CrossRefGoogle Scholar
  24. 24.
    Shindell DT, Rind D, Lonergan P (1998) Increased polar stratospheric ozone loss and delayed eventual recovery owing to increasing green-house gas concentrations. Nature 392: 589–592.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2004

Authors and Affiliations

  • Harry Slaper
    • 1
  • Frank R. de Gruijl
    • 2
  1. 1.Lab. for Radiation ResearchNational Institute for Public Health and the Environment (RIVM)BilthovenThe Netherlands
  2. 2.DermatologyLeiden University Medical CentreLeidenThe Netherlands

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