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The Arrhythmogenic Substrate in Ischemic and Non-ischemic Cardiomyopathies

Structural and Functional Basis of Ventricular Arrhythmias

  • Chapter
Progress in Catheter Ablation

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 241))

Abstract

For the mechanistic study of arrhythmias in clinical practice the terms “arrhythmogenic substrate”, “initiating factor” and “modulating factors” have been introduced.1 We define the substrate as “a pre-existing condition that forms a prerequisite for the induction of an arrhythmia”. For example in the Wolff-Parkinson-White syndrome the substrate is formed by the accessory bundle and removal of the bundle is curative.2 In clinical cardiology the “substrate” is studied by invasive electrophysiology, whereas the “initiating factor” is primarily the subject of non-invasive electrophysiologic studies. Although this approach has proved valuable in the study of the substrate in AV-reentrant arrhythmias it fell short in the mechanistic evaluation of ventricular arrhythmias.1 In ventricular myocardium, multiple mechanisms may underlie the inducibility of a sustained arrhythmia.

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Authors and Affiliations

  1. Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    Ruben Coronel, Antonius Baartscheer, Johannes M. E. Rademaker, Jessica T. Vermeulen & Jacques M. T. de Bakker

Authors
  1. Ruben Coronel
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  2. Antonius Baartscheer
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  3. Johannes M. E. Rademaker
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  4. Jessica T. Vermeulen
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  5. Jacques M. T. de Bakker
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Editor information

Editors and Affiliations

  1. Stanford University, Stanford, California, USA

    Liong Bing Liem (Associate Professor of Medicine, Director) (Associate Professor of Medicine, Director)

  2. Experimental Cardiac Electrophysiology, Stanford University Medical Center, Stanford, California, USA

    Liong Bing Liem (Associate Professor of Medicine, Director) (Associate Professor of Medicine, Director)

  3. University of Toronto, Toronto, Ontario, Canada

    Eugene Downar (Professor of Medicine, Director) (Professor of Medicine, Director)

  4. Invasive Cardiac Electrophysiology, Toronto General Hospital, Toronto, Ontario, Canada

    Eugene Downar (Professor of Medicine, Director) (Professor of Medicine, Director)

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© 2001 Springer Science+Business Media Dordrecht

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Coronel, R., Baartscheer, A., Rademaker, J.M.E., Vermeulen, J.T., de Bakker, J.M.T. (2001). The Arrhythmogenic Substrate in Ischemic and Non-ischemic Cardiomyopathies. In: Liem, L.B., Downar, E. (eds) Progress in Catheter Ablation. Developments in Cardiovascular Medicine, vol 241. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9791-3_1

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  • DOI: https://doi.org/10.1007/978-94-015-9791-3_1

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-5882-9

  • Online ISBN: 978-94-015-9791-3

  • eBook Packages: Springer Book Archive

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