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Altered Bronchodilation and Pulmonary Inflammation in Prostanoid EP2 Receptor Knockout Mice

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Advances in Prostaglandin and Leukotriene Research

Part of the book series: Medical Science Symposia Series ((MSSS,volume 16))

Abstract

Small clinical studies of asthma [1–5] found that inhaled prostaglandin E2 (PGE2) induced bronchodilation and reduced the influx of inflammatory cells in the airways. PGE2 activates four receptors identified as EP1–4 [6,7]. The activation of two of those receptors, the EP2 and the EP4, leads to the stimulation of the adenylyl cyclase and increases intracellular cyclic AMP levels. Therefore, a specific EP2 or EP4 agonist could be considered as a potential treatment for asthma.

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References

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Authors
  1. Francois Nantel
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  2. Danielle Denis
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  3. Simon Wong
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  4. Paul Masson
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  5. Denis Normandin
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  6. Maria Cirino
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  7. Gary P. O’Neill
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  8. Richard M. Breyer
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  9. Kathleen M. Metters
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Editor information

Editors and Affiliations

  1. Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institute, S-171 77, Stockholm, Sweden

    Bengt Samuelsson

  2. Department of Pharmacological Sciences, University of Milan, Milan, Italy

    R. Paoletti , Giancarlo C. Folco  & S. Nicosia ,  & 

  3. Center for Cardiopulmonary Pharmacology, Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy

    Giancarlo C. Folco

  4. Karolinska Hospital, Stockholm, Sweden

    E. Granström

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© 2001 Springer Science+Business Media Dordrecht

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Nantel, F. et al. (2001). Altered Bronchodilation and Pulmonary Inflammation in Prostanoid EP2 Receptor Knockout Mice. In: Samuelsson, B., Paoletti, R., Folco, G.C., Granström, E., Nicosia, S. (eds) Advances in Prostaglandin and Leukotriene Research. Medical Science Symposia Series, vol 16. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9721-0_18

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  • DOI: https://doi.org/10.1007/978-94-015-9721-0_18

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-5881-2

  • Online ISBN: 978-94-015-9721-0

  • eBook Packages: Springer Book Archive

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