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Inflammation pp 167–186Cite as

The Therapeutic Potential of Interleukin 10 in Infection and Inflammation

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Abstract

Interleukin 10 (IL-10), a cytokine with inhibitory activity on inflammation and cell-mediated immune responses, holds enormous potential for the treatment of inflammatory and autoimmune disorders. In addition, IL-10 has also been implicated in the immunopathogenesis of a number of infectious diseases through the use of IL-10 knock-out or IL-10 transgenic mouse models. In this review, we delineate infectious and inflammatory conditions in which IL-10 has shown potential for therapeutic manipulation. Specifically, we review the role of IL-10 in human endotoxemia/sepsis and in HIV infection, conditions for which preliminary phase I trials have recently been undertaken. It is suggested that the therapeutic potential of IL-10 to selectively ameliorate human infectious and inflammatory processes can be realized through a careful selection of the clinical conditions in which patients are undergoing concomitant treatment with anti-microbial regimens.

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Abbreviations

IL-10:

interleukin 10

CMIR:

cell mediated immune responses

IL-10KO:

IL-10 knock-out

HIV:

human immunodeficiency virus

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Authors and Affiliations

  1. Department of Pediatrics, India

    Ashok Kumar & W. David Creery

  2. Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Canada

    Ashok Kumar

  3. Division of Virology and Molecular Immunology, Research Institute, Children’s Hospital of Eastern Ontario, Ottawa, Ontario, Canada

    Ashok Kumar

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  1. Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland

    Andrzej Górski , Hubert Krotkiewski  & Michał Zimecki ,  & 

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Kumar, A., Creery, W.D. (2001). The Therapeutic Potential of Interleukin 10 in Infection and Inflammation. In: Górski, A., Krotkiewski, H., Zimecki, M. (eds) Inflammation. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9702-9_13

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  • DOI: https://doi.org/10.1007/978-94-015-9702-9_13

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