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Clinical Nephrotoxins pp 121–134Cite as

The renal toxicity of beta-lactam antibiotics: Mechanisms and clinical implications

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Abstract

The beta-lactam antibiotics (beta-lactams), are a complex group of bicyclic compounds with the following common features (Fig. 1): a strained, four-membered lactam ring, a nitrogen shared by the lactam and contiguous rings, and a carboxyl on the non-lactam ring removed by one carbon from the shared nitrogen. This central core, variably influenced by a series of side-group substituents, is important to the antibacterial action [1], renal tubular secretion [2], and nephrotoxicity [3] of these antibiotics.

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Authors
  1. Bruce M. Tune
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Editors and Affiliations

  1. Division of Nephrology and Hypertension, University of Antwerp, Belgium

    M. E. De Broe  & G. A. Verpooten  & 

  2. Department of Medicine, The Oregon Health Sciences University, Portland, Oregon, 97201, USA

    G. A. Porter

  3. Division of Nephrology, The Oregon Health Sciences University, Portland, Oregon, 97201, USA

    W. M. Bennett

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Tune, B.M. (1998). The renal toxicity of beta-lactam antibiotics: Mechanisms and clinical implications. In: De Broe, M.E., Porter, G.A., Bennett, W.M., Verpooten, G.A. (eds) Clinical Nephrotoxins. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9088-4_8

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