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Contrast associated nephropathy: Presentation, pathophysiology and management

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Clinical Nephrotoxins

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Abstract

Acute renal failure following intravascular injection of contrast media is an infrequent but serious consequence of intravascular imaging. Of the earliest reported cases where death was reported, a majority had underlying acute or chronic renal damage/disease and subsequently died of uremia [1]. Of the early reports documenting acute oliguric renal failure following contrast media [2, 3] its cause was speculated to be intraluminal obstruction by precipitated Bence-Jones protein. However, as noted by McAfee’s survey it was the advent of aortography that caused a dramatic rise in the frequency of contrast associated nephropathy [4]. It is noteworthy that if post-angiogram abnormalities of renal function were not accompanied by clinical symptoms they were not considered complications of the procedure. Similar results were reported by Idbohrn [5] who concluded that the concentration of contrast medium administered contributed in a linear manner to the risk of renal injury as did the site of injection.

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Authors
  1. George A. Porter
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  2. Dag Kremer
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Editor information

Editors and Affiliations

  1. Division of Nephrology and Hypertension, University of Antwerp, Belgium

    M. E. De Broe  & G. A. Verpooten  & 

  2. Department of Medicine, The Oregon Health Sciences University, Portland, Oregon, 97201, USA

    G. A. Porter

  3. Division of Nephrology, The Oregon Health Sciences University, Portland, Oregon, 97201, USA

    W. M. Bennett

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© 1998 Springer Science+Business Media Dordrecht

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Porter, G.A., Kremer, D. (1998). Contrast associated nephropathy: Presentation, pathophysiology and management. In: De Broe, M.E., Porter, G.A., Bennett, W.M., Verpooten, G.A. (eds) Clinical Nephrotoxins. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9088-4_24

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  • DOI: https://doi.org/10.1007/978-94-015-9088-4_24

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-015-9090-7

  • Online ISBN: 978-94-015-9088-4

  • eBook Packages: Springer Book Archive

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