Abstract
Urokinase plasminogen activator (uPA) is a specific serine protease which converts the zymogen plasminogen into plasmin, a protease of broad specificity. uPA has been implicated in extracellular proteolysis in numerous cellular systems involving cellular migration, tissue remodelling, or invasive growth and metastasis of tumours (1, 2). In macrophages uPA is thought to be involved in cellular migration during the inflammatory response (3, 4) and is bound to a specific receptor on the leading edge of monocytes migrating in vitro (5).
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© 1992 Springer Science+Business Media Dordrecht
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Stacey, K.J. et al. (1992). The regulation of urokinase plasminogen activator gene expression in macrophages. In: van Furth, R. (eds) Mononuclear Phagocytes. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-8070-0_31
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DOI: https://doi.org/10.1007/978-94-015-8070-0_31
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