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Involvement of ELAM-1 in monocyte adherence to and migration across IL-1-stimulated endothelial cell monolayers

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Mononuclear Phagocytes
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Abstract

In response to an inflammatory stimulus, neutrophils adhere to the vascular lining and migrate into the inflamed tissue, followed by monocytes (1). Clinical and experimental evidence has demonstrated the importance of the CD11/CD18 proteins on leukocytes in these processes (2, 3). However, it is now generally accepted that the adherence of leukocytes to cytokine-activated endothelial cells is only in part mediated by CD18dependent mechanisms (3, 4).

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References

  1. Harlan JM. Leukocyte-endothelial interactions (review). Blood 1985, 65:513–525.

    PubMed  CAS  Google Scholar 

  2. Anderson DC, Springer TA. Leukocyte adhesion deficiency: an inherited defect in the MAC-1, LFA-1, and p150,95 glycoproteins. Annu Rev Med 1987, 38:175–198.

    Article  PubMed  CAS  Google Scholar 

  3. Hakkert BC, Rentenaar JM, van Aken WG, Roos D, van Mourik JA. A three-dimensional model system to study the interactions between human leukocytes and endothelial cells. Eur J Immunol 1990, 20:2775–2781.

    Article  PubMed  CAS  Google Scholar 

  4. Luscinskas FW, Brock AF, Arnaout MA, Gimbrone MA Jr. Endothelial-leukocyte adhesion molecule-l dependent and leukocyte (CD11/CD18)-dependent mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine-activated human vascular endothelium. J Immunol 1989, 142:2257–2263.

    PubMed  CAS  Google Scholar 

  5. Bevilacqua MP, Stengelin S, Gimbrone MA Jr, Seed B. Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science, 1989, 243:1160–1165.

    Article  PubMed  CAS  Google Scholar 

  6. Osborn L, Hession C, Tizard R, Vassallo C, Luhowskyj GC, Lobb R. Direct expression cloning of Vascular Cell Adhesion Molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Cell 1989, 59:1203–1211.

    Article  PubMed  CAS  Google Scholar 

  7. Leeuwenberg JMF, von Asmuth EJU, Jeunhomme TMAA, Buurman WA. INF-gamma regulates the expression of the adhesion molecule ELAM-1 and IL-6 production by human endothelial cells in vitro. J Immunol, 1990,145 : 2110–2114.

    PubMed  CAS  Google Scholar 

  8. Elices MJ, Osborn L, Takada Y, Crouse C, Luhowskyj S, Hemler ME, Lobb RR. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell 1990, 60:577–584.

    Article  PubMed  CAS  Google Scholar 

  9. Hemler ME. VLA proteins in the integrin family: structures, functions, and their role on leukocytes. Annu Rev Immunol 1990, 8:365–400.

    Article  PubMed  CAS  Google Scholar 

  10. Rice GE, Munro JM, Bevilacqua MP. Inducible cell adhesion molecule 110 (INCAM-110) is an endothelial receptor for lymphocytes: A CD11/CD18-independent adhesion mechanism. J Exp Med, 1990, 171:1369–1374.

    Article  PubMed  CAS  Google Scholar 

  11. Jaffe EA, Nachman RL, Becker CG, Minick CR. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 1973, 52:2745–2756.

    Article  PubMed  CAS  Google Scholar 

  12. Willems C, Astaldi GCB, de Groot P, Janssen MC, Gonsalves MB, Zeijlmaker WP, van Mourik JA. Media conditioned by cultured human vascular endothelial cells inhibit the growth of vascular smooth muscle cells. Exp Cell Res 1982, 139:191–197.

    Article  PubMed  CAS  Google Scholar 

  13. Roos D, de Boer M. Purification and cryopreservation of phagocytes from human blood. Meth Enzymol 1986, 132:225–243.

    Article  PubMed  CAS  Google Scholar 

  14. Miedema F, Tetteroo PAT, Hesselink WG, Werner G, Spits H, Melief CJM. Both the Fc receptors and lymphocyte-function-associated antigen-1 on human T lymphocytes are required for antibody-dependent cellular cytotoxicity (killer cell activity). Eur J Immunol 1984, 14:518–523.

    Article  PubMed  CAS  Google Scholar 

  15. Leeuwenberg JFM, Jeunhomme TMAA, Buurman WA: Induction of an activation antigen on human endothelial cells in vitro. Eur J Immunol 1989, 19:715–720.

    Article  PubMed  CAS  Google Scholar 

  16. Sanchez-Madrid F, De Landazuri MO, Morago G, Cebrian M, Acevedo A, Bernabeu C. VLA-3: A novel polypeptide association within the VLA molecular complex: cell distribution and biochemical characterization. Eur J Immunol 1986, 16:1343–1349.

    Article  PubMed  CAS  Google Scholar 

  17. Gallin JI, Clark RH, Kimball HR: Granulocyte chemotaxis: an improved in vitro assay employing 51Cr-labeled granulocytes. J Immunol 1973, 110:223–229.

    Google Scholar 

  18. Smith CW, Rothlein R, Hughes BJ, Mariscalco MM, Rudloff HE, Schmalstieg FC, Anderson DC. Recognition of an endothelial determinant for CD18-dependent human neutrophil adherence and transendothelial migration. J Clin Invest 1988, 82:1746–1756.

    Article  PubMed  CAS  Google Scholar 

  19. Lawrence MB, Smith CW, Eskin SG, McIntire LV. Effect of venous shear stress on CD18-mediated neutrophil adhesion to cultured endothelium. Blood 1990, 75:227–237.

    PubMed  CAS  Google Scholar 

  20. Kuijpers TW, Hakkert BC, Hoogerwerf M, Leeuwenberg JFM, Roos D. The role of endothelial leukocyte adhesion molecule-1 (ELAM-1) and platelet-activating factor (PAF) in neutrophil adherence to IL-1-prestimulated endothelial cells: ELAM-1-mediated CD18 activation. Submitted

    Google Scholar 

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© 1992 Springer Science+Business Media Dordrecht

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Hakkert, B.C., Kuijpers, T.W., Buurman, W.A., Van Mourik, J.A., Roos, D. (1992). Involvement of ELAM-1 in monocyte adherence to and migration across IL-1-stimulated endothelial cell monolayers. In: van Furth, R. (eds) Mononuclear Phagocytes. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-8070-0_19

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  • DOI: https://doi.org/10.1007/978-94-015-8070-0_19

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-4171-5

  • Online ISBN: 978-94-015-8070-0

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